vendredi 31 juillet 2015

Is Obesity a dysreward?

http://m.pnas.org/content/112/20/6509.full.pdf


Glucose is not fructose. When glucose is ingested a large insulin response is observed. With fructose the insulin response is less important and the reward system in the brain far less activated.

Keep in mind that the true low GI tuber is Yam not sweet potatoe

FoodSugar (g)Starch (g)Fiber (g)
Potato1.217.32.2
Yam0.523.13.9
Sweet potato6.57.53.3
Grapes15.50.00.9

dimanche 26 juillet 2015

Eggs and CVD

Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis1,2,3

 Authors
  1. Elizabeth J Johnson5,*
  1. 4Tufts Clinical Evidence Synthesis Center, Tufts Medical Center, Boston, MA, and
  2. 5Jean Mayer USDA Human Nutrition, Research Center on Aging at Tufts University, Boston, MA
  1. *To whom correspondence should be addressed. E-mail: elizabeth.johnson@tufts.edu.
  • 1 Supported by USDA agreement 1950-51000-073 and the American Egg Board, Egg Nutrition Center.
  • 2 The funders did not have a role in the study selection, quality assessment, data synthesis, or manuscript preparation.
  • 3 Supplemental Tables 1–10 and Supplemental Figures 1–14 are available from the “Supplemental data” link in the online posting of the article and from the same link in the online table of contents at http://ajcn.nutrition.org.

Abstract

Background: Dietary cholesterol has been suggested to increase the risk of cardiovascular disease (CVD), which has led to US recommendations to reduce cholesterol intake.
Objective: The authors examine the effects of dietary cholesterol on CVD risk in healthy adults by using systematic review and meta-analysis.
Design: MEDLINE, Cochrane Central, and Commonwealth Agricultural Bureau Abstracts databases were searched through December 2013 for prospective studies that quantified dietary cholesterol. Investigators independently screened citations and verified extracted data on study and participant characteristics, outcomes, and quality. Random-effect models meta-analysis was used when at least 3 studies reported the same CVD outcome.
Results: Forty studies (17 cohorts in 19 publications with 361,923 subjects and 19 trials in 21 publications with 632 subjects) published between 1979 and 2013 were eligible for review. Dietary cholesterol was not statistically significantly associated with any coronary artery disease (4 cohorts; no summary RR), ischemic stroke (4 cohorts; summary RR: 1.13; 95% CI: 0.99, 1.28), or hemorrhagic stroke (3 cohorts; summary RR: 1.09; 95% CI: 0.79, 1.50). Dietary cholesterol statistically significantly increased both serum total cholesterol (17 trials; net change: 11.2 mg/dL; 95% CI: 6.4, 15.9) and low-density lipoprotein (LDL) cholesterol (14 trials; net change: 6.7 mg/dL; 95% CI: 1.7, 11.7). Increases in LDL cholesterol were no longer statistically significant when intervention doses exceeded 900 mg/d. Dietary cholesterol also statistically significantly increased serum high-density lipoprotein cholesterol (13 trials; net change: 3.2 mg/dL; 95% CI: 0.9, 9.7) and the LDL to high-density lipoprotein ratio (5 trials; net change: 0.2; 95% CI: 0.0, 0.3). Dietary cholesterol did not statistically significantly change serum triglycerides or very-low-density lipoprotein concentrations.
Conclusion: Reviewed studies were heterogeneous and lacked the methodologic rigor to draw any conclusions regarding the effects of dietary cholesterol on CVD risk. Carefully adjusted and well-conducted cohort studies would be useful to identify the relative effects of dietary cholesterol on CVD risk.

Cancer and sun

Study of cancer mortality rates by region

Milk: grassfed or cornfed? Free range cows or CAFO?

Huge differences depending on food and environment

mardi 21 juillet 2015

Some advices about sport

I have tried to edit the most important advices in short words
No pain no gain
No muscle no speed
No fitness no endurance

But it is not enough.

To improve your health and power of healing
No intermittent fasting no new stem cells

To decrease inflammation
No fat no decrease in inflammation
I need to explain that, if you train hard you will eat some carbs and on free days you should try ketone production by stopping carbs (not only added sugars) and fueling your body with fats.
You only need to eat them in whole food obviously, olives, avocados, nuts, fat fishes and fat free range grassfed cattle and butter instead of oils...

No whole foods no nutrition only calories

jeudi 16 juillet 2015

When advertising a paper could lead to falsely demonize eggs...

In a recent Eurekalert the University of Montreal reported the interesting work of Stéphanie Fulton in Neuropsychopharmacolgy. I haven't still read the paper in details but the data in the abstract are in complete contradiction with the comparison entitling the Eurekalert news...
Fried eggs are not a high fat diet component.
You don't believe me?
Look at the data from the USDA database:

Macronutrients for 100g:

Water g 69.47
Energy kcal 196
Protein g 13.61
Total lipid (fat) g 14.84
Carbohydrate, by difference g 0.83
Fiber, total dietary g 0.0
Sugars, total g 0.40


Lipids
Fatty acids, total saturated g 4.323
Fatty acids, total monounsaturated g 6.182
Fatty acids, total polyunsaturated g 3.251
Fatty acids, total trans g 0.041
Cholesterol mg 401





4,323/14,84= 29% of sat fats,
42% of monounsaturated
22% of PUFA.
So eggs even fried are not a good source of Sat Fats but on the contrary a source of monounsaturated fatty acids. And monounsaturated is the fatty acid in the diet which do not provoke a dysfunctioning dopamine system...
One have to eat 29 eggs per a day to maintain this proportion of sat fats...
So the study of Fulton on rats is quite difficult to imagine in human and seems to be an example of a paper which wants to prove too much about sat fats so that it becomes unreal.

http://www.eurekalert.org/pub_releases/2015-07/uom-tiy071315.php

http://ndb.nal.usda.gov/ndb/foods/show/117?fgcd=&manu=&lfacet=&format=&count=&max=35&offset=&sort=&qlookup=fried+eggs

The anti-meat war becomes academic

http://www.thelancet.com/pdfs/journals/langlo/PIIS2214-109X(14)70381-X.pdf

Even written by a prestigious team it is not evidence based to assess that unprocessed meat in unhealthy...

Synergistic action of nutrients in prostate cancer prevention

Fig. 4. 
Synergistic inhibition of androgen signaling by combinations of phytonutrients. (A and B) LNCaP cells were transiently transfected with the AnRE-LUC reporter and renilla luciferase as in Fig. 3A, stimulated with DHT and treated with the compounds alone or in the indicated combinations. Results are presented as % inhibition relative to the effect of DHT alone. The horizontal lines in the various combinations represent the sum of the inhibitory effects of individual compounds. A representative experiment out of 3 experiments performed in triplicates is presented. Concentrations of the different compounds were: curcumin (2.5 μm in (A) or 1.25 μm in (B)), vitamin E (200 μm), tomato extract (4 μm lycopene), EPA/DHA (500 μm). (C) LNCaP cells were treated as shown in Fig. 3B and supplemented with the different compounds alone or in combinations. PSA protein level was measured in the medium as in Fig. 3B and the results are presented as % inhibition relative to the effect of DHT alone. A representative experiment out of 3 experiments performed in triplicates is presented. Concentrations of the different compounds were: curcumin, 5 μM, vitamin E, 100 μM, lycopene 4 μM.

This paper is a new proof that cancer prevention couldn't be done by increasing one micronutrient through supplementation.

http://www.sciencedirect.com/science/article/pii/S0003986115000806

USA: Fall of CHD mortality

Cardiovascular disease (CVD) mortality trends for males and females (United States: 1979–2011).

page7image1456
Ami Goss 
Kevin Fontaine 
D2
Lchfd

Check Na/K ratio instead of only the amount of NaCl

http://archpedi.jamanetwork.com/article.aspx?articleid=2272973

And the ancestral ratio Raw/Processed foods is a very good index of a healthy Na/K ratio.

Trans fats: good news are very late

http://www.foodnavigator-usa.com/Regulation/Researcher-files-lawsuit-vs-FDA-after-it-ignored-his-petition-calling-for-ban-on-artificial-trans-fats

http://www.medpagetoday.com/PrimaryCare/DietNutrition/52157?xid=nl_mpt_DHE_2015-06-17&eun=g432148d0r




 Bassett, C. M. C.; Edel, A. L.; Patenaude, A. F.; McCullough, R. S.; Blackwood, D. P.; Chouinard, P. Y.; Paquin, P.; Lamarche, B.; Pierce, G. N. (Jan 2010). "Dietary Vaccenic Acid Has Antiatherogenic Effects in LDLr-/- Mice". The Journal of Nutrition 140 (1): 18–24. doi:10.3945/jn.109.105163.

jeudi 2 juillet 2015

Added sugars: glucose and fructose differ and here is why

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130280

Pure glucose do not exist in the wild. Other simple sugars are present in fruit, honey, and milk. They are frequently disaccharides like lactose (Glu-Gal), saccharose (Glu-Fru), so their hydrolysis leads to glucose, galactose or fructose.
Glucose is less sweet than fructose but is rewarding brain centers, fructose is less rewarding but differ in the metabolic pathway and galactose is prooxidant.

http://journals.cambridge.org/download.php?file=%2FBJN%2FBJN96_01%2FS0007114506001772a.pdf&code=840deec832a43919b5d589f01343f27c

[Figure Images/bjn0960056f1.gif]
Fig. 1. Changes in 13C:12C in expired CO2 in response to exercise with ingestion of placebo and 13C-labelled hexoses (means and their standard errors; n 6). ‡Values were significantly different from those for glucose and fructose (P<0 fructose="" galactose.="" glucose="" placebo="" span="">

http://link.springer.com/article/10.2165/00007256-200029060-00004

About  galactose:
"In summary, the importance of normal galactose metabolism was recognized well over 30 years ago when researchers began their pioneering efforts on the four enzymes of the Leloir pathway (4255152). Since that time an enormous amount of biochemical, kinetic, and structural data has been generated on these fascinating enzymes. Interestingly, in the past it has been speculated that enzymes within a given metabolic pathway evolved from one another because of the need to accommodate similar substrates (53). Clearly this is not the case for enzymes of the Leloir pathway. Indeed, questions remain regarding the evolutionary history of this important metabolic cycle."

http://www.jbc.org/content/278/45/43885.long


Pâte à tartiner Malakoff



Bien évidemment ce n'est pas l'huile de colza qui l'améliore mais la réduction modérée du sucre ajouté.
Même à ce niveau de sucre ajouté (32,7%) c'est trop sucré à mon goût et surtout par rapport aux effets du sucre sur notre métabolisme.
Enfin pas d'étiquette nutritionnelle avec les différents nutriments pour 100g...