In my experience the strongest causal risk factor is tobacco smoking. But the risk factor concept is ambiguous as it defines also clinical or biological traits, symptoms or values associated with a complex disease. For instance baldness is associated with CHD. Not causally but probably through an insulinic link.
http://bmjopen.bmj.com/content/3/4/e002537.abstract
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Les commentaires ne sont pas "modérés" je m'en tiens à la rationalité des internautes.