The main immediate clinical consequence of caffeine consumption is an overactive bladder

https://en.wikipedia.org/wiki/Overactive_bladder

https://clinicaltrials.gov/ct2/show/NCT00754260

https://www.healthline.com/health/11-foods-to-avoid-if-you-have-oab#sweeteners

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903463/