Caloric restriction: data on Mice

Survival curves of male mice fed ad libitum,

30% restricted for 2–4 weeks or fasted for 1–3 days prior to induction of 37 min of unilateral renal IRI with contralateral nephrectomy (n = 10–18 per group).

Survival curves of the indicated groups. Survival of animals refed for 2 h, 1 and 2 days was significantly different than ad libitum

fed animals (P < 0.002); survival of animals refed for 4 and 7 days was not significantly different than ad libitum fed animals.

Aging Cell (2010) 9, pp40–53