dimanche 29 décembre 2019
samedi 28 décembre 2019
jeudi 26 décembre 2019
mercredi 25 décembre 2019
Meat: how to increase your cancer risk by transforming real meat: burning, nitrating...
1/ cook but don't burn or char, try tartare too
https://buzzly.fr/manger-de-la-viande-trop-cuite-peut-etre-tres-mauvais-pour-votre-sante.html
Ce n'est pas une question de viande trop cuite c'est une question de viande carbonisée à la flamme.
https://l-express.ca/cuisson-au-barbecue-et-cancer-evitez-de-carboniser/
2/ Processed meat is mainly nitrating it
https://www.healthline.com/nutrition/why-processed-meat-is-bad
https://www.mdpi.com/2072-6643/11/11/2673
Ce n'est pas une question de viande trop cuite c'est une question de viande carbonisée à la flamme.
https://l-express.ca/cuisson-au-barbecue-et-cancer-evitez-de-carboniser/
2/ Processed meat is mainly nitrating it
https://www.healthline.com/nutrition/why-processed-meat-is-bad
https://www.mdpi.com/2072-6643/11/11/2673
Is your Doctor more ignorant of nutrition than you? Probably yes.
https://www.cardiovascularbusiness.com/topics/lipids-metabolic/doctors-ignorance-nutrition-affecting-patients?utm_source=newsletter&utm_medium=cvb_weekend&fbclid=IwAR2Qx5VMWBsbYOGpHGPx7Lu_XTbQg2sV0kfcC5XkEcRMvhJulZUI9xYdQyE
Indeed you are obviously more aware of your genetical susceptibilities and issues with foods.
Indeed you are obviously more aware of your genetical susceptibilities and issues with foods.
lundi 23 décembre 2019
Do you need NAD?
https://www.elysiumhealth.com/en-us/basis
Tru-Niagen
https://blogs.scientificamerican.com/guest-blog/thinning-the-fog-around-sirtuins/
https://www.scientificamerican.com/article/aging-is-reversible-at-least-in-human-cells-and-live-mice/?fbclid=IwAR3kLD7vpveTq_7FrF7tPDAdOgERiJdbLXyF5pVw0BnT1WEN1hfKKKl-ORY
https://www.sciencedirect.com/science/article/pii/S0092867416305943#fig4
https://bio.libretexts.org/Bookshelves/Biochemistry/Book%3A_Biochemistry_Online_(Jakubowski)/08%3A_OXIDATION%2F%2FPHOSPHORYLATION/8B%3A_Oxidative_Enzymes/B02.__The_Chemistry_of_NAD__and_FAD
https://pubmed.ncbi.nlm.nih.gov/3809170-riboflavin-metabolism-in-the-hypothyroid-human-adult/
Tru-Niagen
https://blogs.scientificamerican.com/guest-blog/thinning-the-fog-around-sirtuins/
https://www.scientificamerican.com/article/aging-is-reversible-at-least-in-human-cells-and-live-mice/?fbclid=IwAR3kLD7vpveTq_7FrF7tPDAdOgERiJdbLXyF5pVw0BnT1WEN1hfKKKl-ORY
https://www.sciencedirect.com/science/article/pii/S0092867416305943#fig4
https://bio.libretexts.org/Bookshelves/Biochemistry/Book%3A_Biochemistry_Online_(Jakubowski)/08%3A_OXIDATION%2F%2FPHOSPHORYLATION/8B%3A_Oxidative_Enzymes/B02.__The_Chemistry_of_NAD__and_FAD
https://pubmed.ncbi.nlm.nih.gov/3809170-riboflavin-metabolism-in-the-hypothyroid-human-adult/
samedi 21 décembre 2019
vendredi 20 décembre 2019
Statins and CVD
https://www.sciencedirect.com/science/article/pii/S2213858719303882#fig1
This meta-analysis is indeed a study about interventional clinical trials with drugs (Statins or Statins and Ezetimibe vs no drug) in patients with CVD and the endpoints are clinical events but not death either CV deaths or all deaths.
The issue is that the biomarker control of drug efficiency is not the drug concentration, nor the volume of plaques all over the arterial tree and nor the flow of LDL particles in plaques; it is a fraction of lipid particles in the circulating blood identified by the cholesterol content of those LDL particles. Nothing new indeed.
Statins act as anti-inflammatory drugs for the arterial plaques. They reduce the number of plaque ruptures which occur spontaneously or under stress conditions like surgery, exercise or other circumstances. And it is interesting to observe that the maximum RR effect is in symptomatic patients and especially during the months or 1-2 years following the ischemic event (cf Stroke and statins, 10.1056/NEJMe1914757). This is not according to my point of view a "proof" of the lipid-heart hypothesis. But it is a strong back to use statins in symptomatic patients for a limited time if they succeed after the event to manage their risk factors.
This meta-analysis is indeed a study about interventional clinical trials with drugs (Statins or Statins and Ezetimibe vs no drug) in patients with CVD and the endpoints are clinical events but not death either CV deaths or all deaths.
The issue is that the biomarker control of drug efficiency is not the drug concentration, nor the volume of plaques all over the arterial tree and nor the flow of LDL particles in plaques; it is a fraction of lipid particles in the circulating blood identified by the cholesterol content of those LDL particles. Nothing new indeed.
Statins act as anti-inflammatory drugs for the arterial plaques. They reduce the number of plaque ruptures which occur spontaneously or under stress conditions like surgery, exercise or other circumstances. And it is interesting to observe that the maximum RR effect is in symptomatic patients and especially during the months or 1-2 years following the ischemic event (cf Stroke and statins, 10.1056/NEJMe1914757). This is not according to my point of view a "proof" of the lipid-heart hypothesis. But it is a strong back to use statins in symptomatic patients for a limited time if they succeed after the event to manage their risk factors.
jeudi 19 décembre 2019
Reasonning on observational studies
Dans aucune étude observationnelle la causalité n’est établie. Pourquoi ? Parce que la constatation rétrospective ou prospective quand les deux groupes de comparaison ne sont pas tirés au sort n’est qu’une association, une corrélation. Si bien que le sens de la causalité suspectée n’est pas non plus défini. A peut entraîner B mais B peut aussi entraîner A.
Les études observationnelles avec des critères des facteurs très précis et infalsifiables donne des renseignements utiles. En matière de nutrition avec quatre ou 5000 molécules organiques à chaque repas, des interactions métaboliques qui touchent tous les organes et tous les métabolismes c’est un pur gaspillage d’argent.
Seules des études randomisées qui n’ont pas besoin d’avoir une taille d’échantillons importante mais qui doivent comprendre des données extensives sur le métabolome la génétique sont extraordinairement efficaces pour faire avancer les connaissances et donner des conseils fondés aux patients.
Dans une étude randomisée correctement designee il n’y a pas de causalité inverse.
mercredi 18 décembre 2019
lundi 16 décembre 2019
dimanche 15 décembre 2019
samedi 14 décembre 2019
Coffee: Even roasted it seems that it protects our DNA
It is clearly counter intuitive. Indeed roasting coffee is creating Maillard molecules, acrylamide if temperature is sufficiently high and presumably some tars like burning meat in a barbecue. Personally I don’t like black roasted coffee beans and I do like the taste of slightly roasted blond coffee beans but I’m very reassured by the study on a medical perspective. However that kind of studies have a limit. Looking at the DNA on a short duration exposition of four weeks is relying on one biomarker which is far from mirroring the true risk and the true clinical situation. The clinical situation is consuming roasted coffee during more than 60 years long.
jeudi 12 décembre 2019
lundi 9 décembre 2019
Sun, skin, vitamin D and the gut flora
https://www.frontiersin.org/articles/10.3389/fmicb.2019.02410/full
This is the first study that reports changes in the human gut microbiota in response to UVB light. As decreased exposure to UVB light and subsequent decreased vitamin D production has been suggested to take part in the current rise in chronic inflammatory diseases, the fact that gut microbiota composition could also be a piece in this puzzle opens new avenues for research that needs to be validated in larger cohorts.
https://onlinelibrary.wiley.com/doi/full/10.1111/imm.12939
This is the first study that reports changes in the human gut microbiota in response to UVB light. As decreased exposure to UVB light and subsequent decreased vitamin D production has been suggested to take part in the current rise in chronic inflammatory diseases, the fact that gut microbiota composition could also be a piece in this puzzle opens new avenues for research that needs to be validated in larger cohorts.
https://onlinelibrary.wiley.com/doi/full/10.1111/imm.12939
dimanche 8 décembre 2019
Wrong or useless studies in medicine
Although it is a difficult subject we do have at least in medicine a sieve for the worst studies. Observational studies even true are useless. But the preeminence of these studies is still strong because of several factors and among them the data mania and the magic of stat analysis. First, a cohort paid to have one or two "clinical" (actually a huge very unreliable "questionnaire") assessments for 5 years and a lot of "results". In the same time one or two biological assessments with a huge number of variables. Second, a battery of statistical tests in order to find something like a probability < 0.05. The Graal is so easy.
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020124
https://www.youtube.com/watch?v=MO30X0YlZU0&fbclid=IwAR1Aje3rwCVvYREH832lMwjhoscH46mRxZksTst3mQfxCUpy6MG-nJZ5d1I
https://www.nature.com/news/how-scientists-fool-themselves-and-how-they-can-stop-1.18517?fbclid=IwAR0PpoxHYW8sGXGlsBVHcxsplRPxLn4yDjXp8YEAcgBFFpL2PAQ6r-OtgxA
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020124
https://www.youtube.com/watch?v=MO30X0YlZU0&fbclid=IwAR1Aje3rwCVvYREH832lMwjhoscH46mRxZksTst3mQfxCUpy6MG-nJZ5d1I
https://www.nature.com/news/how-scientists-fool-themselves-and-how-they-can-stop-1.18517?fbclid=IwAR0PpoxHYW8sGXGlsBVHcxsplRPxLn4yDjXp8YEAcgBFFpL2PAQ6r-OtgxA
vendredi 6 décembre 2019
mercredi 4 décembre 2019
The conditionally essential LCPUFA which is forgotten: DHA and veganism is so wrong on this issue!
"Omega-3 Index status >8% correlates positively with brain structure, function and health
Across multiple studies, the Omega-3 Index correlates positively with better brain structure, function and health:
At all ages studied therefore, there is robust support for an Omega-3 Index target range of 8-11% for optimal brain structure, function and health. "
1. Blasbalg TL, Hibbeln JR, Ramsden CE, Majchrzak SF, Rawlings RR. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am J Clin Nutr. 2011;93:950-62
2. Sprague M, Dick JR, Tocher DR. Impact of sustainable feeds on omega-3 long-chain fatty acid levels in farmed Atlantic salmon, 2006-2015. Sci Rep. 2016;6:21892.
3. von Schacky C. w-3 Fettsäuren und Hirnfunktion. Orthomol Med 2016;2:6-10
4. Amen DG, Harris WS, Kidd PM, Meysami S, Raji CA. Quantitative Erythrocyte Omega-3 EPA Plus DHA Levels are Related to Higher Regional Cerebral Blood Flow on Brain SPECT. J Alzheimers Dis. 2017;58:1189-1199
5. Joris PJ, Mensink RP, Adam TC, Liu TT. Cerebral Blood Flow Measurements in Adults: A Review on the Effects of Dietary Factors and Exercise. Nutrients. 2018;10. pii: E530.
6. Schwarz C, Wirth M, Gerischer L, et al. Effects of Omega-3 Fatty Acids on Resting Cerebral Perfusion in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial. J Prev Alzheimers Dis. 2018;5:26-30.
7. Setiawan E, Wilson AA, Mizrahi R, et al. Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes. JAMA Psychiatry. 2015;72:268-75
8. Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans. 2017;45:1105-1115.
9. Schuchardt JP, Hahn A. Bioavailability of long-chain omega-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2013;89:1-8.
10. Davidson MH, Johnson J, Rooney MW, Kyle ML, Kling DF. A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova(®) compared to Lovaza(®) in a pharmacokinetic single-dose evaluation) study. J Clin Lipidol. 2012;6:573-84.
11. Dyerberg J, Madsen P, Møller JM, Aardestrup I, Schmidt EB. Bioavailability of marine n-3 fatty acid formulations. Prostaglandins Leukot Essent Fatty Acids. 2010;83:137-41.
12. Harris WS and von Schacky C. The Omega-3 Index: A New Risk Factor for Death from CHD? Preventive Medicine 2004;39:212-20.
13. Lukaschek K, von Schacky C, Kruse J, Ladwig K. Cognitive impairment is associated with low Omega-3 Index in the elderly. Results from the KORA-Age study. Dementia Geriatr Cogn Dis 2016;42:236-45
14. Ammann EM, Pottala JV, Robinson JG, Espeland MA, Harris WS. Erythrocyte omega-3 fatty acids are inversely associated with incident dementia: Secondary analyses of longitudinal data from the Women's Health Initiative Memory Study (WHIMS). Prostaglandins Leukot Essent Fatty Acids. 2017;121:68-75
15. Tan ZS, Harris WS, Beiser AS, et al. Red Blood Cell Omega-3 Fatty Acid Levels and Markers of Accelerated Brain Aging. Neurology 2012;78:658-64
16. Pottala JV, Yaffe K, Robinson J, Espeland MA, Wallace R, Harris WS. Higher RBC EPA+DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. Neurology 2014;82:435-42
17. Johnston DT, Deuster PA, Harris WS, Macrae H, Dretsch MN. Red blood cell omega-3 fatty acid levels and neurocognitive performance in deployed U.S. Servicemembers. Nutr Neurosci. 2013;16:30-8
18. Bigornia SJ, Scott TM, Harris WS, Tucker KLs. Prospective Associations of Erythrocyte Composition and Dietary Intake of n-3 and n-6 PUFA with Measures of Cognitive Function. Nutrients 2018;10,1253
19. Lin PY, Chiu CC, Huang SY, Su KP. A meta-analytic review of polyunsaturated fatty acid compositions in dementia. J Clin Psychiatry. 2012;73:1245-54
20. Coley N, Raman R, Donohue MC, Aisen PS, Vellas B, Andrieu S. Defining the Optimal Target Population for Trials of Polyunsaturated Fatty Acid Supplementation Using the Erythrocyte Omega-3 Index: A Step Towards Personalized Prevention of Cognitive Decline? J Nutr Health Aging. 2018;22:982-998
21. West, A. L., Kindberg, G. M., Hustvedt, S. O. & Calder, P. C. A Novel Self-Micro-Emulsifying Delivery System Enhances Enrichment of Eicosapentaenoic Acid and Docosahexaenoic Acid after Single and Repeated Dosing in Healthy Adults in a Randomized Trial. The Journal of Nutrition (2018). doi:10.1093/jn/nxy127
22. Qin, Y., Nyheim, H., Haram, E. M., Moritz, J. M. & Hustvedt, S. O. A novel self-micro-emulsifying delivery system (SMEDS) formulation significantly improves the fasting absorption of EPA and DHA from a single dose of an omega-3 ethyl ester concentrate. Lipids Health Dis. 16, 204 (2017).
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| https://www.nutraingredients.com/News/Promotional-Features/DHA-omega-3-fundamental-for-optimal-brain-structure-function-and-health?source=3?utm_source=newsletter_daily&utm_medium=email&utm_campaign=GIN_NId&c=dC5HnbRQjqmt4tS3hMOT3RkPEXHHKv2H&p2= |
Supplements should be regulated as drugs: the case report of this child is a shame for parents
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| This supplement is suspected to have caused an hypokalaemia in a child |
"3.2. Description du cas
Il s’agit d’un enfant de dix ans, mesurant 125 cm et pesant 21 kg, ayant un syndrome de Williams- Beuren (https://en.wikipedia.org/wiki/Williams_syndrome )avec troubles de l'oralité. Jusqu'à ses sept ans, il était sous nutrition entérale par gastrostomie.
Depuis 2015, il consomme quotidiennement quatre flacons de 200 mL d’un CNO hyperénergétique destiné aux adultes. Il mange très peu d'aliments solides ou liquides, en dehors du CNO, qui lui permet une autonomie nutritionnelle (il n'a plus de gastrostomie). Le CNO s'est quasi entièrement substitué au reste de son alimentation, en étant alors utilisé comme un aliment complet alors qu’il s’agit d’un aliment incomplet.
En mars 2019, une hypokaliémie à 2,7 mmol/L (norme : 3,50-5,10 mmol/L) est découverte fortuitement sur un bilan sanguin dans un contexte d'asthénie. La famille rapporte une polyurie avec cinq mictions dans la journée et cinq réveils nocturnes.
Il est hospitalisé du 14 au 18 mars 2019 pour le bilan de cette hypokaliémie.
A l'arrivée, il a une température à 36,5°C, une pression artérielle à 120/69 mmHg. L'auscultation cardiopulmonaire est normale. Il est conscient et orienté. L'abdomen est souple, dépressible et indolore. Il a une tendance à la constipation. Il ne présente pas de myalgies.
La glycémie est à 1,1 g/L, la kaliémie à 3 mmol/L, la natrémie à 139 mmol/L, la créatininémie à 39 μmol/L, l'urémie à 5,5 mmol/L. Les ASAT, ALAT, GGT et CPK sont normales. La kaliurie est à 7 mmol/L, l'osmolalité urinaire à 332 mosm/kg, la rénine à 182 mlUI/L. Le pH sanguin est à 7,4. Le dosage de la calcémie est manquant.
L'echo-doppler rénal ne montre pas d’anomalie hémodynamique. L'ECG montre un allongement de l’intervalle QT mais pas d'aplatissement de l'onde T. Le rythme sinusal est régulier.
Un apport potassique complémentaire est instauré. La kaliémie se normalise avec, à la sortie, une kaliémie à 3,6 mmol/L. Les ionogrammes urinaires mettent en évidence une kaliurèse adaptée. Dans l’hypothèse d’autres carences alimentaires, une supplémentation en calcium et en vitamines est également instaurée."
Il s’agit d’un enfant de dix ans, mesurant 125 cm et pesant 21 kg, ayant un syndrome de Williams- Beuren (https://en.wikipedia.org/wiki/Williams_syndrome )avec troubles de l'oralité. Jusqu'à ses sept ans, il était sous nutrition entérale par gastrostomie.
Depuis 2015, il consomme quotidiennement quatre flacons de 200 mL d’un CNO hyperénergétique destiné aux adultes. Il mange très peu d'aliments solides ou liquides, en dehors du CNO, qui lui permet une autonomie nutritionnelle (il n'a plus de gastrostomie). Le CNO s'est quasi entièrement substitué au reste de son alimentation, en étant alors utilisé comme un aliment complet alors qu’il s’agit d’un aliment incomplet.
En mars 2019, une hypokaliémie à 2,7 mmol/L (norme : 3,50-5,10 mmol/L) est découverte fortuitement sur un bilan sanguin dans un contexte d'asthénie. La famille rapporte une polyurie avec cinq mictions dans la journée et cinq réveils nocturnes.
Il est hospitalisé du 14 au 18 mars 2019 pour le bilan de cette hypokaliémie.
A l'arrivée, il a une température à 36,5°C, une pression artérielle à 120/69 mmHg. L'auscultation cardiopulmonaire est normale. Il est conscient et orienté. L'abdomen est souple, dépressible et indolore. Il a une tendance à la constipation. Il ne présente pas de myalgies.
La glycémie est à 1,1 g/L, la kaliémie à 3 mmol/L, la natrémie à 139 mmol/L, la créatininémie à 39 μmol/L, l'urémie à 5,5 mmol/L. Les ASAT, ALAT, GGT et CPK sont normales. La kaliurie est à 7 mmol/L, l'osmolalité urinaire à 332 mosm/kg, la rénine à 182 mlUI/L. Le pH sanguin est à 7,4. Le dosage de la calcémie est manquant.
L'echo-doppler rénal ne montre pas d’anomalie hémodynamique. L'ECG montre un allongement de l’intervalle QT mais pas d'aplatissement de l'onde T. Le rythme sinusal est régulier.
Un apport potassique complémentaire est instauré. La kaliémie se normalise avec, à la sortie, une kaliémie à 3,6 mmol/L. Les ionogrammes urinaires mettent en évidence une kaliurèse adaptée. Dans l’hypothèse d’autres carences alimentaires, une supplémentation en calcium et en vitamines est également instaurée."
Observational studies are waste of time and waste of money
https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(18)30135-X/fulltext
Just another completely unuseful observational study on carbs.
Just another completely unuseful observational study on carbs.
mardi 3 décembre 2019
Metabolic syndrome: more than an iceberg
https://www.ncbi.nlm.nih.gov/pubmed/24962189
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| Clearly, hyperinsulinism leads to pancreas failure and that is why. |
Facing this huge issue there are still papers advocating carb consumption...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604719/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604719/
lundi 2 décembre 2019
The main immediate clinical consequence of caffeine consumption is an overactive bladder
jeudi 28 novembre 2019
Understanding ketogenic diet and fasting
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| https://www.ncbi.nlm.nih.gov/pubmed/17299079 |
https://newatlas.com/health-wellbeing/long-term-effects-intermittent-fasting-heart-health-mortality/?utm_source=New%20Atlas%20Subscribers&utm_campaign=942c78379f-EMAIL_CAMPAIGN_2019_11_30_08_44&utm_medium=email&utm_term=0_65b67362bd-942c78379f-92471889&fbclid=IwAR0IrBMk7-rLqOoTf_43W2ck7PauBgQH0Bju1ZYXA-cedtgO2onbjiR9TRM
https://medium.com/personal-growth/the-useless-concept-of-calories-50831730cc81
http://shop.dougorchard.com/Fasting-movie-p/fasting.htm
https://www.ncbi.nlm.nih.gov/pubmed/31545298
https://www.nutraingredients.com/Article/2019/08/13/Keto-diet-claims-vs-reality-What-the-science-says/?utm_source=Newsletter_SponsoredSpecial&utm_medium=email&utm_campaign=Newsletter%2BSponsoredSpecial&c=dC5HnbRQjqkUb8%2FailvI0CntIciaAd0s
https://medium.com/personal-growth/the-useless-concept-of-calories-50831730cc81
http://shop.dougorchard.com/Fasting-movie-p/fasting.htm
https://www.ncbi.nlm.nih.gov/pubmed/31545298
https://www.nutraingredients.com/Article/2019/08/13/Keto-diet-claims-vs-reality-What-the-science-says/?utm_source=Newsletter_SponsoredSpecial&utm_medium=email&utm_campaign=Newsletter%2BSponsoredSpecial&c=dC5HnbRQjqkUb8%2FailvI0CntIciaAd0s
mardi 26 novembre 2019
vendredi 22 novembre 2019
Evidence that the liver produces ketone bodies
"3.1. Endocrine Regulation
The general principle of hormonal regulation states that anabolic hormones inhibit, and catabolic hormones stimulate ketogenesis [5]. Insulin, which is the main anabolic hormone, is principally important: in the presence of insulin ketogenesis is strongly inhibited, even when catabolic hormones are also secreted. Insulin acts in two complementary manners: first, it blocks lipolysis in adipocytes; and next, it promotes glucose uptake and oxidation by tissues, which results in elevated succinyl-CoA and malonyl-CoA levels. These intermediates are strong inhibitors of fatty acid oxidation and ketone body formation in liver and other ketogenic tissues. When insulin levels are low, the catabolic hormones, namely glucagon (secreted by the pancreas during hypoglycemia), as well as cortisol, growth hormone, catecholamines, epinephrine, norepinephrine, and thyroid hormones come into prominence [6,7]. They all stimulate lipolysis and the release of free fatty acids, as well as fatty acid transport to the liver and skeletal muscles. Increased influx of fatty acids to the liver induces their β-oxidation and subsequent ketogenesis. Among catabolic hormones, epinephrine and norepinephrine, which drive “fight or flight” reactions to stress, are particularly strong activators of lipolysis, fatty acid oxidation and ketogenesis, and remain active regardless of insulin levels [8,9]."
Exercise
Other circumstances
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The metabolism of ketone bodies: ketogenesis takes place in hepatocyte mitochondria, whereas ketolysis involves utilization of ketone bodies in the mitochondria of peripheral tissues. ACAT1—acetoacetyl-CoA thiolase, Ac-CoA—acetyl-CoA, AcAc-CoA—acetoacetyl-CoA, BDH—β-hydroxybutyrate dehydrogenase, bHB—β-hydroxybutyrate, CPT1—carnitine palmitoyltransferase 1, HMGCL—HMG-CoA lyase, HMGCS2—HMG-CoA synthetase, MCT1—monocarboxylate transporter 1, SCOT—succinyl-CoA:3-ketocid-CoA transferase, TCA—tricarboxylic acid cycle.
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AMPK and mTOR complex 1 (mTORC1) respond to nutrient supply and cellular energy status. AMPK stimulates catabolism and ketogenesis through activation of PPARα and PGC-1α. mTORC1 blocks PPARα and induces anabolic processes, such as protein and lipid biosynthesis. The abbreviations are explained in the text.
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jeudi 21 novembre 2019
We drank milk 6000 years ago
https://link.springer.com/article/10.1007/s12520-019-00911-7
Intolerance to lactose due to the lack of lactase could have been overpassed by fermentation. As fermentation is a spontaneous process it is possible that humans discovered very early the advantage of fermentation. Fermented milk and cheeses didn’t lead to symptoms of lactose intolerance.
https://www.pnas.org/content/113/48/13594.abstract
Intolerance to lactose due to the lack of lactase could have been overpassed by fermentation. As fermentation is a spontaneous process it is possible that humans discovered very early the advantage of fermentation. Fermented milk and cheeses didn’t lead to symptoms of lactose intolerance.
https://www.pnas.org/content/113/48/13594.abstract
mardi 19 novembre 2019
Is it a relief? Or a new pace? (Luke 12/19)
Luke 12:19
19 And I’ll say to myself, “You have plenty of grain laid up for many years. Take life easy; eat, drink and be merry.”’
Keep in mind that Luke didn't add "because we will die TM".
dimanche 17 novembre 2019
samedi 16 novembre 2019
Ketones help to clear flu virus thank to gamma delta T cells and cooperation with lining cells of bronchi
Les corps cétoniques mais pas les graisses aident à éliminer le virus grippal grâce aux cellules T gamma delta et à la coopération avec les cellules qui tapissent les bronches
"Nous proposons que les cellules T puissent servir de modulateur de la fonctionnalité épithéliale en réponse au régime alimentaire et à la disponibilité des éléments nutritifs, en induisant des modifications de la différenciation des cellules épithéliales et de leur fonction d'adaptation au changement de l'environnement. Exploiter les effets bénéfiques de la diète cétogène par le biais des cellules T peut donc offrir une avenue potentielle jusque-là non reconnue pour la prévention et le traitement de la grippe."
Lisez ce papier et vous ne ferez plus de "High Fat Diet".
Une perspective évolutive suggère que: le régime paléo dans l’éco niche était dicté par les saisons, les pénuries et les événements de chasse ou de récolte. Ces événements peuvent avoir été énormes et avoir favorisé le stockage d'aliments ou tout simplement adaptés à la demande. En conséquence, nous étions habitués à alterner au cours de l’année plusieurs périodes de régimes faibles en glucides, extrêmement faibles en glucides, riches en protéines, parfois riches en graisses et rarement riches en glucides. Il est fort probable que nous n'équilibrions pas notre alimentation avec les différents macronutriments et que nous mangions plutôt les aliments principaux disponibles dans le cadre des aliments de saison ou les résultats de la chasse et de la cueillette de la tribu. Et souvent nous étions en jeûne aléatoire.
An evolutionary perspective suggests: paleo diet in the econiche was dictated by seasons, shortages and hunting or harvesting events. These events can have been huge and have promoted storing food or just adapted to demand. Consequently, we were used to alternating during the year several periods of low carb, extremely low carb, high protein sometimes high fat, rarely high carb diets. It is highly probable that we didn't balance our diet with the different macronutrients and rather ate the main food available in the setting of seasonal foods or results of hunting and gathering of the tribe. And frequently we were on aleatory fasting.
https://immunology.sciencemag.org/content/immunology/4/41/eaav2026.full.pdf
"Nous proposons que les cellules T puissent servir de modulateur de la fonctionnalité épithéliale en réponse au régime alimentaire et à la disponibilité des éléments nutritifs, en induisant des modifications de la différenciation des cellules épithéliales et de leur fonction d'adaptation au changement de l'environnement. Exploiter les effets bénéfiques de la diète cétogène par le biais des cellules T peut donc offrir une avenue potentielle jusque-là non reconnue pour la prévention et le traitement de la grippe."
Lisez ce papier et vous ne ferez plus de "High Fat Diet".
Une perspective évolutive suggère que: le régime paléo dans l’éco niche était dicté par les saisons, les pénuries et les événements de chasse ou de récolte. Ces événements peuvent avoir été énormes et avoir favorisé le stockage d'aliments ou tout simplement adaptés à la demande. En conséquence, nous étions habitués à alterner au cours de l’année plusieurs périodes de régimes faibles en glucides, extrêmement faibles en glucides, riches en protéines, parfois riches en graisses et rarement riches en glucides. Il est fort probable que nous n'équilibrions pas notre alimentation avec les différents macronutriments et que nous mangions plutôt les aliments principaux disponibles dans le cadre des aliments de saison ou les résultats de la chasse et de la cueillette de la tribu. Et souvent nous étions en jeûne aléatoire.
Ketones but not fats help to clear flu virus thank to gamma delta T cells and cooperation with lining cells of bronchi
An evolutionary perspective suggests: paleo diet in the econiche was dictated by seasons, shortages and hunting or harvesting events. These events can have been huge and have promoted storing food or just adapted to demand. Consequently, we were used to alternating during the year several periods of low carb, extremely low carb, high protein sometimes high fat, rarely high carb diets. It is highly probable that we didn't balance our diet with the different macronutrients and rather ate the main food available in the setting of seasonal foods or results of hunting and gathering of the tribe. And frequently we were on aleatory fasting.
https://immunology.sciencemag.org/content/immunology/4/41/eaav2026.full.pdf
jeudi 14 novembre 2019
Vitamine E
1/ the best natural source is unfiltered olive oil >20 mg/100 ml
2/ the most affordable is also unfiltered olive oil
3/ Avocados are also great
2/ the most affordable is also unfiltered olive oil
3/ Avocados are also great
mercredi 13 novembre 2019
Autoimmune thyroiditis (Hashimoto disease) could be prevented and its course probably improved by selenium containing foods
What should you measure in the blood?
Vitamin DSelenium 37.00 EUR unreimbursed
Glutathione peroxidase 26.00 EUR unreimbursed
Iron
Iron
TSH
T3 et T3 libre
T4 et T4 libre
Where is selenium?
Mainly in animal foodshttps://www.healthline.com/health/selenium-foods
"Selenium concentration in Brazil nuts can vary by about three orders of magnitude (0.2-512.0 mg/kg) across several regions of
South America (Chang et al., 1995; Secor and Lisk, 1989; Pacheco and Scussel, 2007; Parekh et al., 2008).
The issue with mushrooms is that it could work only if cultured mushrooms for instance Shiitake are enriched in Se: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1750-3841.2012.02837.x
The issue with mushrooms is that it could work only if cultured mushrooms for instance Shiitake are enriched in Se: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1750-3841.2012.02837.x
A trial is on the way, just track the results
https://clinicaltrials.gov/ct2/show/NCT02013479This RCT will probably improve the evidence about selenium supplementation which is uncertain:
https://www.ncbi.nlm.nih.gov/pubmed/23744563
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272877/figure/Fig2/
https://www.ncbi.nlm.nih.gov/pubmed/27683225
And be careful about iodine!
Some studies in different countries have shown that increasing IODINE (virtually always in isolation without taking into consideration other nutrients) can lead to THYROIDITIS:
- Greece:
https://www.ncbi.nlm.nih.gov/pubmed/12855016
https://www.ncbi.nlm.nih.gov/pubmed/30267376
- China:
https://www.ncbi.nlm.nih.gov/pubmed/21444648
https://www.ncbi.nlm.nih.gov/pubmed/27370068
https://www.ncbi.nlm.nih.gov/pubmed/16807415
- Egypt:
https://www.ncbi.nlm.nih.gov/pubmed/18480555
- Brazil:
https://www.ncbi.nlm.nih.gov/pubmed/19554806
https://www.ncbi.nlm.nih.gov/pubmed/19219319
lundi 11 novembre 2019
The raw butter issue in USA
https://reason.com/2019/11/09/why-raw-butter-producers-are-suing-the-fda/
https://www.thekitchn.com/favorite-ingredient-cultured-r-123101
https://www.foodsafetynews.com/2019/08/belgian-experts-examine-listeria-growth-in-butter-made-with-raw-milk/
https://www.wideopeneats.com/margarine-vs-butter/
https://www.outsideonline.com/2394872/what-laird-hamilton-eats
https://www.thekitchn.com/favorite-ingredient-cultured-r-123101
https://www.foodsafetynews.com/2019/08/belgian-experts-examine-listeria-growth-in-butter-made-with-raw-milk/
https://www.wideopeneats.com/margarine-vs-butter/
https://www.outsideonline.com/2394872/what-laird-hamilton-eats
Le concours de l’article le plus stupide sur le paléo continue
https://www.francebleu.fr/emissions/curieux/gironde/le-regime-paleo-un-vrai-plat-d-idioties
https://www.futura-sciences.com/sante/breves/nutrition-regime-paleo-mauvais-coeur-941/
The race for the number one place in the list of the worst paper on Paleo diet is still on.
Among other flaws, in his podcast author Philip Vigier demonstrated in this short statement a clear short sighted vision of history, genomics and evidence-based medicine. He used the word idiotic for Paleo diet. Even this word is wrong.
https://www.futura-sciences.com/sante/breves/nutrition-regime-paleo-mauvais-coeur-941/
The race for the number one place in the list of the worst paper on Paleo diet is still on.
Among other flaws, in his podcast author Philip Vigier demonstrated in this short statement a clear short sighted vision of history, genomics and evidence-based medicine. He used the word idiotic for Paleo diet. Even this word is wrong.
Fermentation process and casein
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487594/
Casein modifications or degradations are a very unknown process especially in old cheeses.
Casein modifications or degradations are a very unknown process especially in old cheeses.
dimanche 10 novembre 2019
vendredi 8 novembre 2019
There is less pollutants in the blood of young people
« We found that older compared with younger adults with morbid obesity had levels of PCBs, OCPs, and PFCs approximately two‐ to fivefold higher at the time of bariatric surgery. More importantly, with rapid weight loss, older adults had greater increases in serum levels of the lipid‐accumulating environmental toxicants PCBs, OCPs, and PBDEs. In contrast, PFCs, which bioconcentrate in the serum, kidneys, and liver (28, 29), showed a completely different response to weight loss. While the older group had higher baseline concentrations, the younger group had a greater increase in the PFC serum levels associated with weight loss. It is important to note that our “older” group was still relatively young, with a mean age of only 47 years. Therefore, they have the prospect, especially after weight loss, of living several more decades with increased exposure to these toxicants. »
https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22618?utm_campaign=RESR_MRKT_Researcher_inbound&af=R&utm_medium=referral&utm_source=researcher_app&sid=researcher
https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22618?utm_campaign=RESR_MRKT_Researcher_inbound&af=R&utm_medium=referral&utm_source=researcher_app&sid=researcher
jeudi 7 novembre 2019
mercredi 6 novembre 2019
mardi 5 novembre 2019
lundi 4 novembre 2019
Le gras au Paléolithique: de Tautavel (France) à Qesem (Israël)
La moelle osseuse et la graisse constituent une source importante de nourriture et ont attiré l'attention des groupes humains depuis la préhistoire. La consommation de moelle a été associée à une consommation immédiate après l’obtention et l'extraction des tissus mous. Nous présentons ici les preuves les plus anciennes de stockage et de consommation tardive de moelle osseuse à Qesem Cave, en Israël (~ 420 à 200 ka). En utilisant des séries expérimentales contrôlant le temps d'exposition et les paramètres environnementaux, associées à des analyses chimiques, nous avons évalué la préservation de la moelle osseuse. La combinaison de résultats archéologiques et expérimentaux nous a permis d’isoler des marques spécifiques liées à l’élimination de la peau sèche et de déterminer un faible taux de dégradation de la graisse médullaire pouvant aller jusqu’à 9 semaines. C’est la première preuve d’un tel comportement, qui n’avait pas encore été identifié, et qui donne un aperçu de la socio-économie des groupes humains qui vivaient à Qesem et qui pourrait ouvrir la voie à de nouveaux modes d’adaptation humaine du paléolithique.
Bone marrow and grease constitute an important source of nutrition and have attracted the attention of human groups since prehistoric times. Marrow consumption has been linked to immediate consumption following the procurement and removal of soft tissues. Here, we present the earliest evidence for storage and delayed consumption of bone marrow at Qesem Cave, Israel (~420 to 200 ka). By using experimental series controlling exposure time and environmental parameters, combined with chemical analyses, we evaluated bone marrow preservation. The combination of archaeological and experimental results allowed us to isolate specific marks linked to dry skin removal and determine a low rate of marrow fat degradation of up to 9 weeks of exposure. This is the earliest evidence of such previously unidentified behavior, and it offers insights into the socio-economy of the human groups who lived at Qesem and may mark a threshold to new modes of Palaeolithic human adaptation.
Bone marrow and grease constitute an important source of nutrition and have attracted the attention of human groups since prehistoric times. Marrow consumption has been linked to immediate consumption following the procurement and removal of soft tissues. Here, we present the earliest evidence for storage and delayed consumption of bone marrow at Qesem Cave, Israel (~420 to 200 ka). By using experimental series controlling exposure time and environmental parameters, combined with chemical analyses, we evaluated bone marrow preservation. The combination of archaeological and experimental results allowed us to isolate specific marks linked to dry skin removal and determine a low rate of marrow fat degradation of up to 9 weeks of exposure. This is the earliest evidence of such previously unidentified behavior, and it offers insights into the socio-economy of the human groups who lived at Qesem and may mark a threshold to new modes of Palaeolithic human adaptation.
vendredi 1 novembre 2019
jeudi 31 octobre 2019
Sugar substitute
There is no SS because if you keep sweet memory taste in your brain you will eat it again.
NAD+ supplements and the heart: improving energy metabolism
NAD supplements and AF: what about the JACC paper?
If the reference paper of your comment is this one (http://www.onlinejacc.org/content/51/1/68) and this related editorial (http://www.onlinejacc.org/content/51/1/75) you should keep in mind that the study was done in cardiac surgery. This means that patients under an extracorporeal bypass did have cardiac arrest following the infusion of a cardioplegic solution. This is more or less generating an ischemic time usually of 30-90 minutes. In this setting, after surgery, blood NADPH oxidase is associated with an increased rate of atrial fibrillation in this study. It means that if the heart is poorly protected or poorly oxygenated or in bad shape before the operation an increase redox activity in mitochodrias of the heart is observed and could be associated with AF. This is a consequence of heart damage but not a direct cause of AF. However, this observation could lead to advise you a stress test in order to eliminate a resting ischemic state which TruNiagen could have unmasked.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660643/
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-016-0267-y
If the reference paper of your comment is this one (http://www.onlinejacc.org/content/51/1/68) and this related editorial (http://www.onlinejacc.org/content/51/1/75) you should keep in mind that the study was done in cardiac surgery. This means that patients under an extracorporeal bypass did have cardiac arrest following the infusion of a cardioplegic solution. This is more or less generating an ischemic time usually of 30-90 minutes. In this setting, after surgery, blood NADPH oxidase is associated with an increased rate of atrial fibrillation in this study. It means that if the heart is poorly protected or poorly oxygenated or in bad shape before the operation an increase redox activity in mitochodrias of the heart is observed and could be associated with AF. This is a consequence of heart damage but not a direct cause of AF. However, this observation could lead to advise you a stress test in order to eliminate a resting ischemic state which TruNiagen could have unmasked.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660643/
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-016-0267-y
Meat, human health and environment: the fallacy of solutions despite a good start...
https://www.nutriting.com/actu/faut-il-diminuer-sa-consommation-de-viande-rouge-pour-la-sante/?fbclid=IwAR1Gv7gZdjLVEZk7vKXaJ4lBD53ufi-Qzdx73dBxcRAFxLnmNIkpcvdXk9Y&v=11aedd0e4327
They just forgot smart innovations in energy. You shouldn't need to live like a caveman.
They just forgot smart innovations in energy. You shouldn't need to live like a caveman.
mercredi 30 octobre 2019
Lactose
Lactose is Glucose-Galactose
Donc 1g de lactose = environ 0,5g de chaque.
Masse moléculaire:
Glu 180,155
Gal 180,156
Lac 342,296
Donc 1g de lactose = environ 0,5g de chaque.
Masse moléculaire:
Glu 180,155
Gal 180,156
Lac 342,296
lundi 28 octobre 2019
dimanche 27 octobre 2019
Human nutrition in crisis of rationality: "experts" have warnt against a risk of 18% for processed meat eating equally as they did for a risk of 1900% for tobacco smoking
Experts who did not do a new study who did not do a meta-analysis met in Lyon to tell us what we already knew: it's sworn to spit eating red meat is burdened with a low risk of increased colorectal cancer and eating processed meats is associated with a significant relative risk of 18% per daily serving.
To understand smoking increases the risk of lung cancer by 1900%. Having chronic pancreatitis (often related to alcohol) increases the risk of pancreatic cancer by 1900-2000%.
Smoking and drinking increase the risk of cancer of the upper aerodigestive tract by approximately 29900%!
This is the media storm is emotional and seduces the irrational people. Which are numerous.
Nutrition humaine en période de crise de rationalité: les "experts" ont mis en garde contre le risque de 18% pour la viande transformée, de la même manière que pour le risque de 1900% pour le tabagisme
Des Experts qui n'ont pas fait une nouvelle étude qui n'ont pas fait une méta-analyse se sont réunis à Lyon pour nous dire ce que nous savions déjà: c'est juré craché manger de la viande rouge est grevé d'un faible risque d'augmentation de cancer colorectal et manger des viandes transformées est grevé d'un risque relatif significatif de 18% par portion journalière.
Pour comprendre fumer augmente le risque de cancer du poumon de 1900 %. Avoir une pancréatite chronique (souvent liée à l'alcool) augmente le risque de cancer du pancréas de 1900-2000 %.
Fumer et boire augmente le risque de cancer des VADS d'environ 29900 %!
Voilà la tempête médiatique est émotionnelle et elle séduit les irrationnels. Qui sont nombreux.
To understand smoking increases the risk of lung cancer by 1900%. Having chronic pancreatitis (often related to alcohol) increases the risk of pancreatic cancer by 1900-2000%.
Smoking and drinking increase the risk of cancer of the upper aerodigestive tract by approximately 29900%!
This is the media storm is emotional and seduces the irrational people. Which are numerous.
Nutrition humaine en période de crise de rationalité: les "experts" ont mis en garde contre le risque de 18% pour la viande transformée, de la même manière que pour le risque de 1900% pour le tabagisme
Des Experts qui n'ont pas fait une nouvelle étude qui n'ont pas fait une méta-analyse se sont réunis à Lyon pour nous dire ce que nous savions déjà: c'est juré craché manger de la viande rouge est grevé d'un faible risque d'augmentation de cancer colorectal et manger des viandes transformées est grevé d'un risque relatif significatif de 18% par portion journalière.
Pour comprendre fumer augmente le risque de cancer du poumon de 1900 %. Avoir une pancréatite chronique (souvent liée à l'alcool) augmente le risque de cancer du pancréas de 1900-2000 %.
Fumer et boire augmente le risque de cancer des VADS d'environ 29900 %!
Voilà la tempête médiatique est émotionnelle et elle séduit les irrationnels. Qui sont nombreux.
vendredi 25 octobre 2019
If you suppress sugar, don't forget to add salt... Overall if you exercise
I have discovered that by chance. In winter we were in half pension for skiing and we ate a lot of cheeses, alone or in omelettes or in "fondue". I noted that at the end of the week my sweet tooth after a full day of ski decreased and even disappeared. I began to translate this fact for biking (the sport where I was the most in-demand of sugar) and it worked.
jeudi 24 octobre 2019
We need a better agriculture id est with higher added value and less subsidies
 |
| OECD: value-added by agriculture, fisheries, forestry. |
mardi 22 octobre 2019
vendredi 18 octobre 2019
jeudi 17 octobre 2019
Gastric cancer: smoking and Helicobacter led to a higher risk
https://cancerpreventionresearch.aacrjournals.org/content/12/10/667
Because of the lack of understanding of the complex and serial events which precede a gastric tumour, we under-estimate the carcinogenic potential of smoking and we let people playing Russian roulette
"Smoking is an established risk factor for gastric cancer development. In this study, we aimed to assess prospectively the association of smoking with gastric cancer risk in 1,446 non-cardia gastric cancer cases and 1,796 controls from China, Japan, and Korea with consideration of Helicobacter pylori infection as a potential effect modifier. Applying logistic regression models stratified by study and adjusted for age and sex we found that current, but not former, smoking was significantly associated with gastric cancer risk [OR = 1.33; 95% confidence interval (CI), 1.07–1.65]. However, the association was significant only in H. pylori sero-positive individuals determined by 3 different sero-markers: overall sero-positivity, sero-positivity to the onco-protein CagA, and sero-positivity to the gastric cancer associated sero-marker HP0305 and HP1564. Specifically, a significant interaction was found when stratifying by HP0305/HP1564 (Pinteraction = 0.01) with a 46% increased risk of gastric cancer among HP0305/HP1564 sero-positive current smokers (95% CI, 1.10–1.93) as opposed to no increased gastric cancer risk among HP0305/HP1564 sero-negative current smokers (OR = 0.93; 95% CI, 0.65–1.33). We confirmed that current smoking is associated with an increased gastric cancer risk, however, only among individuals that are simultaneously sero-positive for the leading causal factor for gastric cancer, H. pylori."
Gastric cancer and especially its deadly form named signet-ring cell gastric carcinoma is poorly understood despite its association with HP.
In conclusion, our results from this large prospective
consortium of East Asian studies confirmed that current
smoking increases the risk of developing non-cardia
gastric cancer, however, only among study participants simultaneously harboring antibodies to H. pylori, CagA-positive H. pylori, or the gastric cancer risk marker H. pylori HP0305/HP1564. Our findings suggest that in areas of
high H. pylori prevalence like East Asia, smoking status is a
further risk marker of gastric cancer incidence,and potentially smoking cessation could be an effective strategy to reduce gastric cancer risk.
Because of the lack of understanding of the complex and serial events which precede a gastric tumour, we under-estimate the carcinogenic potential of smoking and we let people playing Russian roulette
"Smoking is an established risk factor for gastric cancer development. In this study, we aimed to assess prospectively the association of smoking with gastric cancer risk in 1,446 non-cardia gastric cancer cases and 1,796 controls from China, Japan, and Korea with consideration of Helicobacter pylori infection as a potential effect modifier. Applying logistic regression models stratified by study and adjusted for age and sex we found that current, but not former, smoking was significantly associated with gastric cancer risk [OR = 1.33; 95% confidence interval (CI), 1.07–1.65]. However, the association was significant only in H. pylori sero-positive individuals determined by 3 different sero-markers: overall sero-positivity, sero-positivity to the onco-protein CagA, and sero-positivity to the gastric cancer associated sero-marker HP0305 and HP1564. Specifically, a significant interaction was found when stratifying by HP0305/HP1564 (Pinteraction = 0.01) with a 46% increased risk of gastric cancer among HP0305/HP1564 sero-positive current smokers (95% CI, 1.10–1.93) as opposed to no increased gastric cancer risk among HP0305/HP1564 sero-negative current smokers (OR = 0.93; 95% CI, 0.65–1.33). We confirmed that current smoking is associated with an increased gastric cancer risk, however, only among individuals that are simultaneously sero-positive for the leading causal factor for gastric cancer, H. pylori."
Gastric cancer and especially its deadly form named signet-ring cell gastric carcinoma is poorly understood despite its association with HP.
In conclusion, our results from this large prospective
consortium of East Asian studies confirmed that current
smoking increases the risk of developing non-cardia
gastric cancer, however, only among study participants simultaneously harboring antibodies to H. pylori, CagA-positive H. pylori, or the gastric cancer risk marker H. pylori HP0305/HP1564. Our findings suggest that in areas of
high H. pylori prevalence like East Asia, smoking status is a
further risk marker of gastric cancer incidence,and potentially smoking cessation could be an effective strategy to reduce gastric cancer risk.
 |
| Gastric cancer |
mercredi 16 octobre 2019
Fallacy of the so called longevity drinks: milk, orange juice and coffee
https://annals.org/aim/article-abstract/2643433/association-coffee-consumption-total-cause-specific-mortality-among-nonwhite-populations?doi=10.7326%2fM16-2472
Perhaps
https://www.liebertpub.com/doi/10.1089/jmf.2013.0034
Certainly not look at the type of proof: it is completely biased. the study is about measuring antioxidants in the blood after drinking orange juice not about life expectancy or any other chronic disease prevalence! And above all those study is done in hyper cholesterolemic and hyper triglyceridemic patients
https://foodandnutritionresearch.net/index.php/fnr/article/view/794
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950929/
https://www.bmj.com/content/349/bmj.g6015/rr/804415
Perhaps
https://www.liebertpub.com/doi/10.1089/jmf.2013.0034
Certainly not look at the type of proof: it is completely biased. the study is about measuring antioxidants in the blood after drinking orange juice not about life expectancy or any other chronic disease prevalence! And above all those study is done in hyper cholesterolemic and hyper triglyceridemic patients
https://foodandnutritionresearch.net/index.php/fnr/article/view/794
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950929/
https://www.bmj.com/content/349/bmj.g6015/rr/804415
mardi 15 octobre 2019
Vitamin D: debate about optimal serum concentrations
http://darwinian-medicine.com/the-vitamin-d-levels-of-the-hadzabe-and-the-maasai-an-important-study-that-flew-under-the-radar/?fbclid=IwAR1PyCsHdKCaAR95aLSaiyomz83_Ouqoq7N7yz4AvqaupypyGbPNbQ0dSsc
The question is: does our genome optimally function with less D?
The question is: does our genome optimally function with less D?
Some definitions about LC diets
LC or ULC diets are an input advice diet: you monitor input id est what you eat
Ketogenic diet is an output metabolic marker diet: you monitor ketonuria and ste that yu get a ketogenic metabolic state
Ketone diet is a supplementary diet: you monitor what you eat because you add ketones bodies
It is complicated that is why I advise doing a LC diet, it is simple, efficient and sustainable. don't forget to monitor very closely (I mean suppress usually) the different starches.
Ketogenic diet is an output metabolic marker diet: you monitor ketonuria and ste that yu get a ketogenic metabolic state
Ketone diet is a supplementary diet: you monitor what you eat because you add ketones bodies
It is complicated that is why I advise doing a LC diet, it is simple, efficient and sustainable. don't forget to monitor very closely (I mean suppress usually) the different starches.
lundi 14 octobre 2019
Irish genome and Neolithic diet.
"Modern Europe has been shaped by two episodes in prehistory, the advent of agriculture and later metallurgy. These innovations brought not only massive cultural change but also, in certain parts of the continent, a change in genetic structure. The manner in which these transitions affected the islands of Ireland and Britain on the northwestern edge of the continent remains the subject of debate. The first ancient whole genomes from Ireland, including two at high coverage, demonstrate that large-scale genetic shifts accompanied both transitions. We also observe a strong signal of continuity between modern day Irish populations and the Bronze Age individuals, one of whom is a carrier for the C282Y hemochromatosis mutation, which has its highest frequencies in Ireland today."
https://www.pnas.org/content/early/2015/12/22/1518445113
"The Neolithic and Bronze Age transitions were profound cultural shifts catalyzed in parts of Europe by migrations, first of early farmers from the Near East and then Bronze Age herders from the Pontic Steppe. However, a decades-long, unresolved controversy is whether population change or cultural adoption occurred at the Atlantic edge, within the British Isles. We address this issue by using the first whole genome data from prehistoric Irish individuals. A Neolithic woman (3343–3020 cal BC) from a megalithic burial (10.3× coverage) possessed a genome of predominantly Near Eastern origin. She had some hunter–gatherer ancestry but belonged to a population of large effective size, suggesting a substantial influx of early farmers to the island. Three Bronze Age individuals from Rathlin Island (2026–1534 cal BC), including one high coverage (10.5×) genome, showed substantial Steppe genetic heritage indicating that the European population upheavals of the third millennium manifested all of the way from southern Siberia to the western ocean. This turnover invites the possibility of accompanying introduction of Indo-European, perhaps early Celtic, language. Irish Bronze Age haplotypic similarity is strongest within modern Irish, Scottish, and Welsh populations, and several important genetic variants that today show maximal or very high frequencies in Ireland appear at this horizon. These include those coding for lactase persistence, blue eye color, Y chromosome R1b haplotypes, and the hemochromatosis C282Y allele; to our knowledge, the first detection of a known Mendelian disease variant in prehistory. These findings together suggest the establishment of central attributes of the Irish genome 4,000 y ago."
https://www.pnas.org/content/early/2015/12/22/1518445113
"The Neolithic and Bronze Age transitions were profound cultural shifts catalyzed in parts of Europe by migrations, first of early farmers from the Near East and then Bronze Age herders from the Pontic Steppe. However, a decades-long, unresolved controversy is whether population change or cultural adoption occurred at the Atlantic edge, within the British Isles. We address this issue by using the first whole genome data from prehistoric Irish individuals. A Neolithic woman (3343–3020 cal BC) from a megalithic burial (10.3× coverage) possessed a genome of predominantly Near Eastern origin. She had some hunter–gatherer ancestry but belonged to a population of large effective size, suggesting a substantial influx of early farmers to the island. Three Bronze Age individuals from Rathlin Island (2026–1534 cal BC), including one high coverage (10.5×) genome, showed substantial Steppe genetic heritage indicating that the European population upheavals of the third millennium manifested all of the way from southern Siberia to the western ocean. This turnover invites the possibility of accompanying introduction of Indo-European, perhaps early Celtic, language. Irish Bronze Age haplotypic similarity is strongest within modern Irish, Scottish, and Welsh populations, and several important genetic variants that today show maximal or very high frequencies in Ireland appear at this horizon. These include those coding for lactase persistence, blue eye color, Y chromosome R1b haplotypes, and the hemochromatosis C282Y allele; to our knowledge, the first detection of a known Mendelian disease variant in prehistory. These findings together suggest the establishment of central attributes of the Irish genome 4,000 y ago."
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