Pure EPA could lower CV events of an additional 25%: REDUCE-IT

https://www.vascepa.com/about-vascepa

http://investor.amarincorp.com/news-releases/news-release-details/reduce-ittm-cardiovascular-outcomes-study-vascepar-icosapent

https://www.apnews.com/e9c15bf076708c5c165d7c8e54b2f005

https://www.cnbc.com/video/2018/09/24/amarin-ceo-on-vascepa-heart-drug-trial.html


The major effect of EPA at 4g/d is an anti-inflammatory effect

http://www.pnas.org/content/early/2017/07/06/1610325114

http://www.pnas.org/content/102/21/7671

https://dysnutrition.blogspot.com/2015/04/gum-and-your-health-w3-pufa-are.html


Indeed aspirin and n-3 are my cocktail for acute inflammatory reactions that cause pain.


EPA and DHA (and also DPA) lead to Resolving, Protectins and Maresins. And Low-dose aspirin (up to 100 mg) leads to more stable lipoxins (lipoxin being derived from arachidonic acid):


https://www.ncbi.nlm.nih.gov/pubmed/28987723


https://www.ncbi.nlm.nih.gov/pubmed/19597002


https://www.ncbi.nlm.nih.gov/pubmed/15471991


But given the bad results of the latest study in elderly individuals https://www.ncbi.nlm.nih.gov/pubmed/30221597 I would embrace what you suggest: small dose every other day.

The pro-resolvin angle is really interesting, as is the effects asprin play in that. It would appear a remarkably small dose (say 40mg every other day) may dramatically improve that process.


I believe several folks have mentioned NOT liking the risk/reward story around asprin, but any thoughts on this? Great podcast that digs into this:


https://www.ihmc.us/stemtalk/episode-69/


https://www.wsj.com/articles/surprise-heart-data-is-just-the-beginning-for-amarin-1537803479

https://www.medscape.com/viewarticle/902478#vp_2