Hypotensive events and orthostatic hypotension in patients taking cardiovascular drugs

Table 1 resumes cardiovascular drugs potentially implicated in hypotensive events and orthostatic hypotension.

PHARMACOLOGICAL CLASS	HYPOTENSION OH (DATA SHEET)	REF	POPULATION	N	ASSOCIATION WITH OH	ADJUSTMENT FOR
NITRATES	Hypotension/OH (contraindicated in presence of severe hypotension)	Vara Gonzalez 2001 Mussi 2009   Kamaruzzaman 2009	Elderly (≥65 years) hypertensive Access to Emergency Department due to syncope (>65 years) Women (60-80 years)	295 259   3775	RR 3.9; 95% CI 1.6-9.8 RR 5.20; 95% CI 1.99-13.61; p<0 .001="" 0.51-0.96="" 0.70="" 95="" ci="" nbsp="" p="0.05</font">	Not specified Age, sex, comorbidities, posology Age, drugs
CALCIUM CHANNELS BLOCKERS	Hypotension	Luukinen 1999   Rose 2000 Rose 2006   Fedorowski 2010	Elderly (>70 years)   General population (mean age 54 years)   General population (mean age 54 years) General population (mean age 66 years)	833   2433 13152   101	RR 2.31, 95% CI 1.14-4.68 Hypertensive: not associated with OH; Normotensive: associated with OH; p<0 .0001="" 1.03-27.14="" 5.29="" 95="" associated="" ci="" hypertensive:="" oh="" p="0.046</font" rr="" with="">	Not specified Age, sex, ethnic groups   Not specified Age, sex, BMI
ACE-INHIBITORS	Hypotension/OH	Kamaruzzaman 2009     Fedorowski 2009	Women (60-80 years)     469 hypertensive during treatment vs 453 normotensives (mean age 62 years)	3775     922	RR 1.27; 95% CI 1.00-1.61;  p=0.04 Protective effect RR 0.41; 95% CI 0.18-0.93; p=0.03	Age; not significant if corrected for comorbidities and lifestyle Not specified
DIURETICS	Hypotension/OH	Luukinen 1999 Mussi 2009   Hirai 2009	Elderly (>70 years) Access to Emergency Department due to syncope (>65 years) Type 1 diabetes (mean age 45 years)	833 259   440	RR 2.29; 95% CI 1.15-4.59 RR 3.73; 95% CI 1.23-11.28; p=0.02   RR 1.84; 95% CI 1.01-3.38; p<0 .05="" font="">	Not specified Age, sex, comorbidities, posology Age, sex, BMI
LOOP DIURETICS	Hypotension/OH	Fedorowski 2010	Syncope due to OH (mean age 66 years)	101	RR 10.22; 95% CI 1.22-89.08; p=0.032	Age, sex, BMI
THIAZIDE DIURETICS	Hypotension/OH	Kamaruzzaman 2009	Women (60-80 years)	3775	RR 1.25; 95% CI 1.02-1.53; p< 0.05	Age
β- BLOCKERS	Hypotension/OH	Vara Gonzalez 2001  Kamaruzzaman 2009	Elderly  (≥65 years) hypertensive Women (60-80 years)	295 3775	RR 4.25; 95% CI 1.15-15.48 RR 1.58; 95% CI 1.19-2.09; p<0 .01="" font="">	Not specified Age, drugs, comorbidities, lifestyle
α-BLOCKERS	Hypotension/OH	Kamaruzzaman 2009	Women (60-80 years)	3775	RR 1.81; 95% CI 1.08-3.03; p<0 .05="" font="">	Age

Table 1: Cardiovascular drugs potentially implicated in hypotensive events and orthostatic hypotension. OH: orthostatic hypotension; RR: relative risk; CI 95%: 95% confidence interval; N: number of subjects.

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