Biases in the comprehension of atheroma: experimental studies vs human ones and lipid profile vs delayed mortality

1/  http://www.nature.com/nature/journal/v515/n7527/pdf/515346a.pdf

Mice and human a very important genomics difference

2/ Lipid profile is NOT the main risk factor and is very complex to interpret

- LDL chol is a weak risk factor versus Tobacco or sedentary life style

- LDL chol is like total chol a few years ago, it lacks of specificity because particle size is key

- unconventional lipid risk factors are usually missing in studies especially old studies like: HDL ApoB100, Lpa, TG, insulin

- the role of oxLDL is not clear