NAD+ supplements and the heart: improving energy metabolism

NAD supplements and AF: what about the JACC paper?
If the reference paper of your comment is this one (http://www.onlinejacc.org/content/51/1/68) and this related editorial (http://www.onlinejacc.org/content/51/1/75) you should keep in mind that the study was done in cardiac surgery. This means that patients under an extracorporeal bypass did have cardiac arrest following the infusion of a cardioplegic solution. This is more or less generating an ischemic time usually of 30-90 minutes. In this setting, after surgery, blood NADPH oxidase is associated with an increased rate of atrial fibrillation in this study. It means that if the heart is poorly protected or poorly oxygenated or in bad shape before the operation an increase redox activity in mitochodrias of the heart is observed and could be associated with AF. This is a consequence of heart damage but not a direct cause of AF. However, this observation could lead to advise you a stress test in order to eliminate a resting ischemic state which TruNiagen could have unmasked.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660643/

https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-016-0267-y