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jeudi 24 avril 2014

Do you know that potatoe chips do have a deep reward effect on your brain!

Figure 5 Activation differences related to snack food (potato chips) vs. standard chow in representative brain structures.

Sugar, diabetes, is there a relationship?

Association of Sugar Availability (kcal/person/day) with Log Diabetes Prevalence, Adjusted for Selection Bias
Effect of Sugar Availability
0.008 (0.0009)***
Effect of Sugar Hazard Rate l
-1.08 (0.66)
p<0 .05="" i="" nbsp="" p="">
Note: Robust standard errors in parentheses clustered by country. Models include controls used in the basic specification in equation 1.

l is the hazard rate of sugar availability, also referred to as the Inverse Mills Ratio.

Figure 2 Adjusted association of sugar availability (kcal/person/day) with diabetes prevalence (% adults 20–79 years old).

Montignac diet in rats

Natural and very ancient GMO

 "We present evidence for neochrome in hornworts (a bryophyte lineage) and demonstrate that ferns acquired neochrome from hornworts via horizontal gene transfer (HGT)."


More on saturated fats

dimanche 20 avril 2014


Extremely important to understand: reshape your workout schedules

Une excellente bière, décantée mais non filtrée, malheureusement sucrée

L'œuf d'oie comment le gober

Great taste. In order to eat all the stuff you need to aspirate very strongly. This kind of egg is not available all of the year so when you find it take it!

Rosette de Montalet faussement appelée tradition car contenant du sucre!

Comment on peut le constater ce saucisson est fabriqué  avec du dextrose et du sirop de glucose.
La tradition du saucisson sec c'est sel, poivre, fermentation.

jeudi 17 avril 2014

Calorie restriction revisited!/menu/main/topColumns/topLeftColumn/pdf/488569a.pdf

Sat fats, CVD and the conventional guidelines: time to change?

Major step in Rheumatoid Arthritis?

The etiology of rheumatoid arthritis (RA) is unknown,
but both environmental and genetic factors are likely to
play roles in its pathogenesis. Periodontal disease (PD),
an inflammatory disease of tooth-supporting structures,
may be an environmental trigger for RA. Compared
with healthy controls, PD is more frequent in RA
patients, both in those with new-onset and in those with
long-standing disease, even when potential confounding
factors such as smoking are taken into account [1-5].
Furthermore, there is increasing evidence of a role for
PD pathogens, particularly Porphyromonas gingivalis (Pg),
in RA pathogenesis. Pg is the only prokaryote known to
possess a peptidylarginine deiminase (PAD), an enzyme
that catalyzes the posttranslational modification of arginine residues to citrulline. Although citrullination may
occur more generally in sites of inflammation, antibodies
to citrullinated proteins (anti-cyclic citrullinated peptide
(anti-CCP) antibodies) are specific for RA and are now
valuable diagnostic markers for the disease [6]. CCP antibodies are associated with a more aggressive course [7]
and may be detected prior to the onset of clinical disease
[8], suggesting a role in RA pathogenesis. Pg, through its
PAD enzyme, may citrullinate host or bacterial proteins
[9], altering their antigenicity and triggering autoimmunity
and RA in predisposed individuals [9,10]. Further support
for this hypothesis comes from animal models. Pg enolase
has been found to cause arthritis in DR4-IE-transgenic
mice [11], and Pg infection has been shown to exacerbate
collagen antibody-induced arthritis [12].

Coffee and cholesterol

Systematic Review

European Journal of Clinical Nutrition 66, 872-877 (August 2012) | doi:10.1038/ejcn.2012.68

The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials

L Cai, D Ma, Y Zhang, Z Liu and P Wang



Numbers of epidemiological studies assessing coffee consumption and serum lipids have yielded inconsistent results. We aimed to evaluate the effects of coffee intake on serum lipids.


We searched several English and Chinese electronic databases up to September 2011 for randomized controlled trials of coffee on serum lipids. Weighted mean effect size was calculated for net changes in serum lipids by using random-effect models or fixed-effect models. Subgroup and meta-regression analyses were conducted to explore possible explanations for heterogeneity among trials.


Twelve studies conducted in Western countries with a total of 1017 subjects were identified. Meta-analyses showed, on average, drinking coffee for 45 days was associated with an increase of 8.1 mg/dl (95% confidence interval (CI): 4.5, 11.6; P<0 .001="" 5.4="" cholesterol="" class="mb" for="" span="" style="background-color: transparent !important; background-image: none !important; background-position: initial initial !important; background-repeat: initial initial !important; display: inline !important; font-family: 'arial unicode ms', 'lucida grande', 'lucida sans unicode', sans-serif !important; font-size: inherit !important; font-weight: inherit !important; line-height: inherit !important; padding: 0px !important; visibility: visible !important;" total=""> 

mg/dl (95% CI: 1.4, 9.5; P=0.009) for low-density lipoprotein cholesterol (LDL-C) and 12.6 mg/dl (95% CI: 3.5, 12.6; P=0.007) for triglyceride (TG). The increase in TC were greater in trials using unfiltered coffee and caffeinated coffee as the treatment group. Those who had hyperlipidemia were more sensitive to the cholesterol-raising effect of coffee. Meta-regression analysis revealed a positive dose-response relation between coffee intake and TC, LDL-C and TG.


The intake of coffee especially unfiltered coffee is contributed significantly to the increase in TC, LDL-C and TG, and the changes were related to the level of intake. Studies of coffee intake on serum lipids in Asian populations should be performed.

Lipoprotein particle sizes

Relative sizes of lipoproteins
Chylomicrons are 1000 nm of diameter
1 000 000 nano-meters = 1 millimeter
1000 nm = 1/1000 mm
Note that LDL may vary in size

Dysnutrition in our times means globesity

Une position très sage du Conseil Médical Suisse sur les statines en prévention primaire

Le réflexe hypercholestérolémie = prescription de statines est à bannir!

mardi 8 avril 2014

Aaron Blaisdell and his team discovered a link between junk food and impaired motivation in rats

My opinion is that when you replace happiness or satisfaction of your needs by pleasure you induce an estate of low motivation. When pleasure is a reward after high and strenuous work out the limit is your fitness level and regulation occurs by feedback. When you can for a low cost indulge your body and brain with shoots of sugar it's different.

Junk food is supposed to induce a very fast and rep pleasure and doing so to impair the brain chemistry.

L'étude en français:

1/ L'auteur de l'article sur laziness et junk food s'appelle Aaron Blaisdell.
2/ Encore une fois l'interprétation des études doit être factuelle:
- c'est une étude expérimentale sur des rats femelles
- la junk food en question c'est des sucres rapides et des , il faut le préciser car c'est capital
- dans l'autre groupe les rattes mangent du mais ecrasé et de la farine de poisson
- au bout de trois mois les rattes sous sucres rapides deviennnet obèses ...
Donc ce n'est pas "la junk food et le surpoids entrainent etc..."
C'est chez les rattes les sucres rapides entrainent OBESITE et PERTE DE MOTIVATION OU PARESSE.

Red meat and D2

Seasonal variations of gut flora

Mélanome and BRAF

What is BRAF?
A gene which codes for protein kinase spelled B-Raf

File:Signal transduction pathways.svg

dimanche 6 avril 2014

Beers or chemical beverages?

We need labels with all the ingredients of industrial foods.
We also need labels with the different treatments for non-industrial foods.
German beers producers stick to a law of purity. Time to extend this agreement to other countries like US? The power of consumers is huge but they don't use it...

jeudi 3 avril 2014

Protein study and bias

About fat tissue and our ancestors

It is obvious that in La Caune d'Arago in South France ground in the caves is covered with broken bones (400 000 years ago).

“Clearly much more has to be done on the functionality of this, but it’s tempting to think it’s linked with some of the differences in sugar metabolism that have been picked up already,” writes paleoanthropologist Chris Stringer of the Natural History Museum in London, who is not a member of the team, in an e-mail. “Neandertals might have had adaptations to get through the stress of northern winters that moderns could pick up through introgression.”

Be careful with antibiotics. They can kill bacteria which are your friends

D2 prevention: why do we do nothing?

What is processed meat and why you should avoid it