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lundi 27 avril 2015

Is it possible to reduce CRP?

Background: Mushrooms are widely cited for their medicinal qualities, yet very few human intervention studies have been done using contemporary guidelines.

Objective: The aim of this study was to determine whether consumption of whole, dried Lentinula edodes (shiitake) mushrooms could improve human immune function. Primary objectives were to ascertain whether L. edodesconsumption would improve γδ-T cell proliferation and activation responses, quantify a dose response, and elicit cytokine secretion patterns. Secondary objectives included determining changes in natural killer T (NK-T) cell proliferation and activation, secretory immunoglobulin A (sIgA) in saliva, and C-reactive protein (CRP) in serum.

Design: Fifty-two healthy males and females, aged 21–41 years, participated in a 4-week parallel group study, consuming either 5 or 10 g of mushrooms daily. Each subject had blood drawn before and after 4 weeks of daily L. edodes consumption. Saliva and serum were also collected. Peripheral blood mononuclear cells were cultured in autologous serum for 24 hours or 6 days, stained, and examined by flow cytometry.

Results: Eating L. edodes for 4 weeks resulted in increased ex vivo proliferation of γδ-T (60% more, p < 0.0001) and NK-T (2-fold more, p < 0.0001) cells. Both cell types also demonstrated a greater ability to express activation receptors, suggesting that consuming mushrooms improved cell effector function. The increase in sIgA implied improved gut immunity. The reduction in CRP suggested lower inflammation. The pattern of cytokines secreted before and after mushroom consumption was significantly different; consumption resulted in increased interleukin (IL)-4, IL-10, tumor necrosis factor (TNF)-α, and IL-1α levels, a decreased macrophage inflammatory protein-1α/chemokine C-C ligand 3 (MIP-1α/CCL3) level, and no change to IL-6, IL-1β, MIP-1β, IL-17 and interferon (IFN)-γ levels.

Conclusions: Regular L. edodesconsumption resulted in improved immunity, as seen by improved cell proliferation and activation and increased sIgA production. The changes observed in cytokine and serum CRP levels suggest that these improvements occurred under conditions that were less inflammatory than those that existed before consumption.

Mother vinegar

Whole food Diet

dimanche 26 avril 2015

You are not what You eat

Don't worry about the ph of your food


Paleo dieters need soil and soil microbiotia

Should we need to wash our veggies?

Molecular mimetism


Paleo meats and fats

Medecine de caisse pour diabétique par la cnam: un désastre

samedi 25 avril 2015


Jews ancestors butchered elephants

Crohn's disease

Crohn's disease

PUFA and cvd

Fat depots and CR vs exercise

mercredi 15 avril 2015

High fat diet

Gum and your health: W3 PUFA are the precursors of Resolvin E1
  • Original Article

Resolvin E1 Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis

  1. Thomas E. Van Dyke
+Author Affiliations
  1. From the Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA (H.H., A.K., D.N., T.E.V.D.); Beirut Arab University, Beirut, Lebanon (R.A.); Department of Biophysics, Boston University School of Medicine, MA (J.H.); and Department of Biomedical Engineering, Boston University, MA (N.G.).
  1. Correspondence to Hatice Hasturk, DDS, PhD or Thomas E. Van Dyke, DDS, PhD, The Forsyth Institute, 245 First St, Suite 1757, Cambridge, MA 02142. or

Taste and flavor of foods

Be careful it works with unprocessed foods!

dimanche 12 avril 2015

Insulin requirements and diabetes


ADHD and smoking during pregnancy

Do you eat paleofibers?

Sugar lobby

Statins are not efficient in prevention

Sat fats a culprit ?

jeudi 9 avril 2015

French and swiss paradoxes share a trait: cheeses consumption

Abstract Image

"Cheese and milk consumption decreased urinary choline and TMAO levels and increased fecal excretion of acetate, propionate, and lipid." 

mercredi 8 avril 2015

Tooth decay

 "The way we treat teeth today is not ideal. When we repair a tooth by putting in a filling, that tooth enters a cycle of drilling and refilling as, ultimately, each 'repair' fails.
"Not only is our device kinder to the patient and better for their teeth, but it's expected to be at least as cost-effective as current dental treatments. Along with fighting tooth decay, our device can also be used to whiten teeth."

Oleocanthal in olives and olive oil: prefer olives and unfiltered recent olive oil

Oleocanthal concentration in EVOO is highly variable, ranging from as little as 0.2 mg/kg to as high as 498 mg/kg (Gomez-Rico et al., 2006). Such variation in oleocanthal concentration amongst differing EVOOs may be due to multiple factors that have the capacity to modify the concentration of this compound (Carrasco-Pancorbo et al., 2005). These factors include: method of phenolic extraction and quantification, geographic region of olive growth, olive tree cultivar, agricultural techniques applied to cultivate olives, olive maturity, processing of the olives to oil, storage of oil, and domestic heat application to oil.

mardi 7 avril 2015

Glyphosate and bacteria

Kurenbach B, Marjoshi D, Amábile-Cuevas CF, Ferguson GC, Godsoe W, Gibson P, Heinemann JA. Sublethal Exposure to Commercial Formulations of the Herbicides Dicamba, 2,4-Dichlorophenoxyacetic Acid, and Glyphosate Cause Changes in Antibiotic Susceptibility in Escherichia coli and Salmonella enterica serovar Typhimurium. MBio. 2015 Mar 24;6(2). pii: e00009-15. doi: 10.1128/mBio.00009-15.

Conclusions hâtives dans la plupart des journaux qui relatent cette étude. 
Et pourtant:

"Les herbicides ne sont pas très toxiques pour les bactéries testées, à savoir E. coli et Salmonella enterica serovar Typhimurium : la bactérie reste vivante, mais elle active des pompes protéiques pour se libérer des toxines. Ce mécanisme de défense peut favoriser l’apparition de résistances croisées. « L’exposition à ces pesticides rend les pathogènes plus forts. »
L’utilisation excessive et inappropriée des antibiotiques compromet l’efficacité à long terme des thérapies qui utilisent les antibiotiques. L’émergence de la résistance aux antibiotiques est le résultat de l’utilisation des antibiotiques. La résistance aux antibiotiques induite par les pesticides pourrait aussi affecter les abeilles étant donné que de nombreuses ruches sont maintenant traitées avec des antibiotiques."

Eggs: not the end of the story

Inside Med Diet

jeudi 2 avril 2015

Paleo works on a short term basis for D2 patients

Linda Frasseto is working on paleo since years. We need more long term studies on paleo diet which can only be granted by public funds.

Sarcopenia is a major issue of aging

CONCLUSIONS: It is concluded that leucine supplementation was found to exert beneficial effects on body weight, body mass index, and lean body mass in older persons in those subjects already prone to sarcopenia, but not muscle strength. However, due to the heterogeneity between the trials included in this systematic review, further studies adopting a homogenous design with respect to participant characteristics duration as well as the kind and amount of daily supplement in use are required.

Cancer patients are disabled by sarcopenia. It seems that EPA can help.

Au bord de la Méditerranée du saumon d'élevage, des crevettes de Malaysie (?) ...
Mais par contre le restaurateur connait l'importance du sauvage!
Il assure que son thym en est. On est rassuré.
Comment acheter chez Métro et vendre un menu dit de Pâques à 22 euro.
On pourrait faire un contre menu:

Coquillages de l'étang de Leucate
Poisson sauvage suivant arrivage
Agneau catalan fermier et sa ratatouille
Salade de fruits rouges ou patisserie au choix

Two eggs a day for D2 patients?

mercredi 1 avril 2015

Should you stop to take FO or KO?

It appears that the supplement food industry had tried with success to bypass evidence based medicine and grew on unproven basis. The backlash of the public didn't occur but industrial leaders of the field should think twice before doing business as usual.