BMI update

 Can you comment on this change?

BMI, 95th percentile and the shift of obesity (https://www.cdc.gov/growthcharts/extended-bmi.htm?fbclid=IwAR1qjkqRL8LPoiLTTtsnS1vDDVytxZIY2jRm3IbxP8A60ldcU3dLA-7al-s). 

Masking is a total failure: Omicron BQ 1.1 wave in France

 

Game

Always game

Lunch

During this event the context is serious:

Salads

Q: How do I know if my salad is actually healthy? Which ingredients should I add to my salads, and which should I avoid?


A: Salad is usually a healthy food, but only if you add the right combination of ingredients and stay away from store-bought bottled dressing.



To build a great salad, start with lettuce or leafy greens. It may surprise you to learn that the type of greens you choose doesn’t really matter that much. Compared to other greens, iceberg lettuce probably has the fewest nutrients, but pretty much all lettuces are low in vitamins and minerals. Dark leafy greens like spinach have more micronutrients, but the type of iron in spinach is poorly absorbed, and there’s plenty of oxalate, so be careful if you’re prone to kidney stones.




The main health benefit of lettuce and other greens in a salad is the fiber. Salads are usually packed with fiber, which is a nutrient — just not for you! Fiber is really food for the microbiome, the trillions of bacteria that live in your gut. Fiber is also the key to metabolic health. Bacteria in your gut turn fiber into short-chain fatty acids, which can regulate immune function and keep inflammation in check.









To increase the fiber in your leafy green salad, add assorted vegetables, like broccoli and green peppers, and add beans and lentils.


But the healthiest salads include plenty of other good-for-you ingredients, such as antioxidants. Antioxidants are chemicals that are essential for your liver, which detoxify virtually all the environmental poisons that enter the body. To perform this magic trick, your liver needs these antioxidants.



For antioxidants, try chopped colorful vegetables (the darker, the better), chopped fresh fruits, herbs (fresh or dried) and spices. Then add proteins, like free-range eggs, pastured beef, fish, chicken, tofu, beans or lentils.

Add fats and fermented foods to your salad


Now layer on some whole-food fats — including avocado, olives, nuts, and seeds. Nuts and seeds (like chia seeds and walnuts) are replete with the anti-inflammatory alpha-linolenic acid (ALA), an omega-3 fatty acid shown to reduce risk for heart disease.



For other sources of omega-3s, try small fish, such as anchovies (commonly found in Caesar salads). You can also include other wild-caught fish (sardines, salmon, mackerel) or chicken (free-range, pasture-raised chicken has fewer antibiotics).



Cheeses are a fantastic addition because they contain odd-chain fatty acids, which are protective against diabetes and heart disease. We’ve all been taught to avoid fats because they have more calories, but dairy fatty acids are unique in that they have a specific phospholipid on their end which prevents inflammation. Just don’t use American cheese, which is not actually cheese. Instead, try varieties such as feta, cotija, parmesan and mozzarella.


Bonus points go to kale, cabbage, and Brussels sprouts — cruciferous vegetables that can increase your body’s own natural production of antioxidants and stimulate the production of liver detoxification enzymes. Another bonus: fresh tomatoes contain lycopene, an antioxidant that supports ocular function and prevents cataracts.



Adding fermented foods such as kimchi and sauerkraut can give you a gut-friendly boost, as can homemade dressings made with natural, unsweetened yogurt. And fermented foods already have short-chain fatty acids in them.





Avoid store-bought salad dressings


Okay. Now let’s talk about salad dressings. To make a great homemade dressing, focus on ingredients such as extra virgin olive oil, avocado oil, tahini, vinegar, Dijon, herbs, spices and citrus juices low in sugar (lemon, lime, grapefruit).


The oleic acid in olive oil activates the liver to produce a factor that speeds up metabolism. The acetic acid in vinegar inhibits an enzyme that breaks down starches in the mouth, thus reducing the rate of glucose that appears in your bloodstream. Some homemade dressings get extra antioxidants from spices and seasonings such as ginger, garlic, turmeric, thyme and oregano.



But the same can’t be said about most store-bought dressings. Store-bought versions are often made with canola and soybean oils, which are chock full of linoleic acid, an inflammatory omega-6 fatty acid.



They can also sneak in large amounts of fructose (the sugar molecule), in the form of cane sugar, high-fructose corn syrup or honey — which harm mitochondria, the energy-producing factories that power each of your cells. When your mitochondria don’t work right, your blood glucose and insulin spike, and your liver has no choice but to turn the fructose into fat — driving fatty liver and insulin resistance and potentially furthering your risk of developing heart disease, cancer and diabetes.


You might be surprised at how common it is for sugar to sneak into bottled dressings. For example, high-fructose corn syrup is the second ingredient in Kraft’s Creamy French dressing, which has five grams of added sugar. And watch out for fat-free dressings — for instance, Ken’s Sundried Tomato Vinaigrette has 12 grams of added sugar.



Store-bought dressings can also contain ingredients that are bad for your gut and the trillions of bacteria that reside there. These bacteria send chemical signals to your brain asking to be fed. If you don’t feed your bacteria, they actually start to feed on you — stripping the mucin, a protective layer, right off your intestinal cells. Over time, this can lead to irritable bowel syndrome, inflammatory bowel disease and altered intestinal permeability, which some people call “leaky gut.” It can also cause systemic inflammation.



Store-bought dressings often contain emulsifiers, such as carboxymethylcellulose, polysorbate-80 or carrageenan, which keep the fat and water from separating — and can dissolve that protective mucin layer in your gut. Those pesky added sugars can also cause bad microbiome bacteria to proliferate, potentially leading to gastrointestinal distress, gas, bloating, diarrhea and inflammation.

Croutons and crispy things


But that doesn’t mean you should skip the dressing. Studies have shown that fats — such as in avocados — actually help your body absorb the nutrients from some vegetables. The key is to choose the right ingredients and, ideally, make your own dressing at home.




It’s also a good idea to steer away from “crispy” things (such as fried onions and tortilla strips), which are often fried in seed oils at high temperatures, risking the formation of trans fats and acrylamide, a known carcinogen. I’d also suggest being cautious about dried fruits; some varieties and brands cover them in sugar to make them sweeter and more palatable.


And lastly, beware of processed breads. A Caesar salad is not a Caesar salad without croutons — but commercial croutons are typically packed with preservatives, sodium and vegetable oils. Bake your own croutons, or pair your salad with a slice of sourdough bread. But please, don’t eat the fried tortilla bowl.

Check actual atheroma instead of undiscriminate blood lipids

Lipids and atheroma.
Interesting series of papers on this subject. IMO even the ApoB lipoprotein discrimination power appears weak (comparatively of LDL or the ratio TG/non-HDL cholesterol). In this setting, the measurement of atheroma by US at the carotid bifurcation or the femoral bifurcation is, however later, but highly discriminate and specific. It is remarkable that the cost, time and invasiveness are minimal or null. These arteries are under the skin, highly susceptible to being first infiltrated by inflammation and our ultrasonic apparatuses are now incredibly easy to use with very precise images and measurements.
I would add that the CT score will easily complete this atheroma checkup. A person with no atheroma in these three sites has a very weak ischemic CV risk even if the LDL is > to the "standards". It is cheap, and ionization is only x2 that of a lumbar spine x-ray...

https://www.fda.gov/radiation-emitting-products/medical-x-ray-imaging/what-are-radiation-risks-ct 

Série intéressante d'articles sur ce sujet. A mon avis même le pouvoir de discrimination des lipoprotéines ApoB apparaît faible (comparativement au LDL ou au rapport TG/cholestérol non HDL). Dans ce contexte, la mesure de l'athérome par échographie au niveau de la bifurcation carotidienne ou de la bifurcation fémorale est cependant plus tardive, mais très discriminante et spécifique. Il est remarquable que le coût, le temps et le caractère invasif soient minimes ou nuls. Ces artères sont sous la peau, très susceptibles d'être d'abord infiltrées par l'inflammation et nos appareils à ultrasons sont maintenant incroyablement faciles à utiliser avec des images et des mesures très précises.
J'ajoute que le score CT complétera facilement ce bilan d'athérome. Une personne sans athérome dans ces trois sites a un risque CV ischémique très faible même si le LDL est > aux "normes". C'est bon marché, et l'ionisation n'est que x2 celle d'une radiographie du rachis lombaire...

In JAMA
https://jamanetwork.com/journals/jamacardiology/article-abstract/2786334 

https://jamanetwork.com/journals/jamacardiology/fullarticle/2786333 

Falafel Égyptien

Falafel égyptien
On peut utiliser des fèves fraîches ou congelées et c'est meilleurs quand elles sont petites. On peut aussi ajouter de la viande

À peu de choses près l'exception qui confirme la règle: nous avons parfaitement raison de nous opposer au bannissement des fromages au lait cru dont les Camemberts

 

Délicieux fromage cétogène...

Carb <0.5g/l and still live bacteria...

Overview of the purported pathophysiological mechanisms explaining the association between sarcopenia and cognitive function.

 

https://academic.oup.com/biomedgerontology/article/77/10/1959/6602136?login=false 

Overview of the purported pathophysiological mechanisms explaining the association between sarcopenia and cognitive function. Yellow marked fields could also be affected by the mediating role of exercise. Aβ = amyloid beta; BBB = blood–brain barrier; BDNF = brain-derived neurotrophic factor; CRP = C-reactive protein; CNS = central nervous system; CDLK-5 = cyclin-dependent-like kinase 5; FNDC5 = fibronectin type III domain containing 5; IDE = insulin-degrading enzyme; IGF-1 = insulin-like growth factor 1; IL-6 = interleukin 6; ROS = reactive oxygen species; SASP = senescence-associated secretory phenotype; UPS = ubiquitin–proteasome system.

Keto-Champagne?

 https://shop.philipponnat.com/collection/royale-reserve-non-dose/

Unfortunately, this Champagne is sold.

It advertises 0g/l of sugar, which means complete fermentation. Does it mean that there is also 0g/L of sugar in the liquor?

The question is asked through the website.

And the answer came a few minutes later:

Bonjour Monsieur,

 

Nous vous remercions pour votre message et pour l’intérêt que vous portez à notre cuvée Royale Réserve Non dosé.

Effectivement cette cuvée n’est pas dosée, pas de liqueur d’expédition ajouté.

Mais il reste dans le vin des résidus de glucose/fructose de la liqueur de tirage pour la prise de mousse.

Dans les analyses ils ont trouvé 0.7 g/L de Glucose/Fructose.

 

Cordialement

 

Nicoletta de Nicolo

 

T +33 (0)3 26 56 93 00 ~ F +33 (0)3 26 56 93 18

I will try it when it will available on the website. 
Just a tip for diabetic patients:
0,7g/l is not traces nor 0g/l. When drinking wines in gnéral keep an eye on the residual sugar content.

High blood glucose, high Insulin, high IGF

Diminuer les carbs?
Diminuer les calories?
En termes de besoins cela dépend de l'âge.
Pour les adultes c'est rationnel. Maintenir les apports en protéines et en gras et diminuer les carbs. Tous... Surtout les ajoutés car ce sont les mêmes certes mais cela fait plus!
Les enfants c'est autre chose mais 80-90% de glucides au petit déjeuner c'est nouveau ( au sens evolutionniste) et les csq sont réelles.
1/ oui grâce au shoot d'insuline cela fait grandir, je sais les calories aussi.
2/ même l'oeil et donc plus de myopes cela est assez bien lié à l'IGF ( https://jamanetwork.com/journals/jamaophthalmology/fullarticle/1106565), (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991122/#:~:text=Genetic%20studies%20have%20been%20used,et%20al.%2C%202012), ce point est controversé
3/ en termes d'obésité compte tenu de l'effondrement de la dépense ce n'est pas favorable et cela nous le voyons sur la plage d'années en années.

Paleo-diet

Au contraire, I would have expected you to cry Eureka!

I think it is a great reminder that we must forever cease confounding Genotype with Phenotype..

Previous studies on human evolution were based on the paleonathropology study of bone and brain phenoytypes. Bone from fossils etc and brain phenotypes  are deduced from the skull/brain cavity.

The bone phenotypes showed massive differences, which were presumed to be due to changes in genes.

But you know better than anyone in the world that the biggest loser in the Neolithic diet is brain, and I contend bone is the next biggest loser.

So back in the day, paloeanthropologists made the best conclusions from their fossils (how many do they have now- I think your books Nutrition and Evolution says you could put them all into an SUV and still have room for groceries).

But they always presumed that phenotype was determined by genotype.

Diet has a bigger effect on phenotype than genotype. We all know that diet is the main determinant of phenotype otherwise we shouldn't be having this discussion.

Just to outline my view of the sequence of destruction of bone and brain which led to the erroneous conclusion that our brains shrank because they were somehow better....(because evolution does NOT always does what we want it to),

Heretic alert!

1. Discovery that cooking makes inedible species edible (or at least no longer lethal). These inedible species also can store for long periods. Increases available calories (primary determinant of population size) and reduces winter starvation (a major determinant of death rate and the need to fight neighbours). Total calories increased 2-4 times (and 10 times in winter). Population carrying capacity increases 2-4 times, winter starvation death rates collapse.

2. Discovery that the food is the seed leads to farming. Desecrate the environment and replace it with edible species. Increases calories per hectare 10-100 times. Population carrying capacity increases 10-100 times. Winter starvation death eliminated. Population boom. Fertile crescent population explosion (followed by soil salination and desertification but that was later).

3. Bone nutrition is greatly affected. (lack of sunlight leads to low vitamin D, high acid load, etc) Pelvic inlet depth size collapses. Death of mother and child during childbirth increases dramatically (the biggest nexus in human evolution).

4. Evolution solves the problem the quickest way- select for smaller skulls and smaller brains. This happened immediately. Later on the much slower process of selecting for larger pelvises occurred.

The shattering conclusion- evolution does what works, not what we want. It does not select for bigger brains if this increases maternal infant mortality. It will select for smaller brains if that reduces maternal infant mortality.

Weston Price's classic book Nutrition and Physical Degeneration outlined that recently Westernised populations immediately needed Caesarean sections and also had massive decimations of the population numbers and gross changes in facial phentypes. These initial decimations were presumably followed by population booms from the higher calories. I presume we have all read this book, it can be downloaded on the web. A big book but essential reading.

Eureka! Hopefully you are not reading this in the bath tub.

Hi Michael,

Big eyes- that is interesting! Eyes fascinate me.

We all remember that Weston Price "Nutrition and Physical Degeneration" documents that
1. the Neanderthal cave paintings in Lascaux, France show stars in the constellation Pleiades (Subaru in Japanese, look at the car symbol) INCLUDING stars not seen by Europeans until the invention of the telescope.
2. Captain Cook visited New Zealand in the 1700's and observed that the Maoris could see the moons of Jupiter with the naked eye, and proved this by telling an observer with a telescope when the eclipse occurred.

Reymond tested the eagle and the hawk and found their vision to be 6/1.2

The vision of the eagle approaches the theoretical limits of physics.

Hugh Taylor MJA 1981 visual acuity of Traditional Aborigine= 6/1.4

(Reymond) the eagle has 6/1.2. The Aborigine has slightly better shade discrimination, putting their overall vision at equal with an eagle.

So it is likely that the Neanderthal had vision superior to the eagle.

Of course today Australian Aborigines have amongst the worst eye health in the world, another case of "Diet has a bigger effect on phenotype than genotype"

Regards

Ben

3 Attachments

 

 

Hi Michael,

Big eyes- that is interesting! Eyes fascinate me.

We all remember that Weston Price "Nutrition and Physical Degeneration" documents that
1. the Neanderthal cave paintings in Lascaux, France show stars in the constellation Pleiades (Subaru in Japanese, look at the car symbol) INCLUDING stars not seen by Europeans until the invention of the telescope.
2. Captain Cook visited New Zealand in the 1700's and observed that the Maoris could see the moons of Jupiter with the naked eye, and proved this by telling an observer with a telescope when the eclipse occurred.

Reymond tested the eagle and the hawk and found their vision to be 6/1.2

The vision of the eagle approaches the theoretical limits of physics.

Hugh Taylor MJA 1981 visual acuity of Traditional Aborigine= 6/1.4

(Reymond) the eagle has 6/1.2. The Aborigine has slightly better shade discrimination, putting their overall vision at equal with an eagle.

So it is likely that the Neanderthal had vision superior to the eagle.

Of course today Australian Aborigines have amongst the worst eye health in the world, another case of "Diet has a bigger effect on phenotype than genotype"

Regards

Ben

3 Attachments

 

 

Silphion

 https://www.nationalgeographic.com/history/article/miracle-plant-eaten-extinction-2000-years-ago-silphion?utm_content=223310249&utm_medium=social&utm_source=facebook&hss_channel=fbp-297483026945793

The danger of general assumptions is equal to that of sectarian diets

 https://www.outsideonline.com/health/nutrition/there-are-no-rules-healthy-eating/

Flexibility but only with whole foods. 


No flexibility with products.

Labels or scores are not the solution to the diabesity epidemics

 https://www.wsj.com/articles/nutrition-advocates-push-for-front-of-package-labels-that-highlight-fat-sugar-levels-11662456602?mod=article_inline

https://www.wsj.com/articles/food-health-eating-label-nutrition-packaging-11662758704?mod=e2fb&fbclid=IwAR3dpexN9XvRaDIIOx5uZxdO70tCLiq7iQbuCHFDxnKJIjz_xPsOK5ms6xM

There is no clinical evidence that compliance with nutritional scores leads to weight loss.


The only label needed is the one that stipulates components in the case of processed food and the nutritional values of 100g of all foods.

How The Independent and Slate take the side of veganism

https://www.slate.fr/story/233351/menu-typique-cuisine-prehistorique-cereale-viande-lait-ecosse-etude-nourriture

This is a fake news.

It is not about Paleolithic era but Neolithic era… consequently, as we know for long, people are practicing agriculture, have domesticated some mammals and gathered milk. They still gather wild veggies and fruits and hunter small animals.

Nothing new.

I am very surprised of the order in the subtitle: cereals milk and meat. No obviously, veggies mainly wild, mushrooms, meat mainly from hungered animals, fishes and especially salmon, then milk ans mainly spontaneously fermented milk, some cereals and beer…

Every day advice about immunity

 

Do you need supplements? Do you need them for immunity?

Sun exposure, Cod liver oil are preferable to pure D3

Oysters are preferable to zinc supplements

Vitamin C in lemons is preferable to supplements because fermented products are already present in a low-carb paleo-inspired diet. Fermented veggies, fermented raw milk or cheeses are a great source of healthy bacteria and by-products of fermentation.

Curcumin is very tasteful in Rougaille saucisse or Rougaille fish.

My advice: 

Keep with tasty whole foods and enjoy your meals.
The most toxic beverage for immunity is alcohol and for respiratory infection it is smoke.
The fastest fuel for bacteria is pure sugar.

Broths, soups, bouillons

 https://www.elle.fr/Elle-a-Table/Recettes-de-cuisine/Soupe-de-poisson-exotique-2948954 

https://www.elle.fr/Elle-a-Table/Les-dossiers-de-la-redaction/News-de-la-redaction/Souping-3615641?fbclid=IwAR38EWu4ESmEXYBdj7G6ZcOeC6KYIRv7S8HGlnEw6qGus-8FDwjhrKdWLq4 

The aim of broths is to hydrate and nourrish.

They are perfectly compatible with diets. They are cheap and easily frozen for low-cost home production.

Some basic broths are useful: bone broth, algae broth, fish soup and meat broth. These basic broths may be added with different veggies and aromates.

Zinc

Don't miss it

The difference between meat and transformed meat...

 

Do you "believe" that this is meat? It is a product. "pur porc" is a scam. This is a transformed food product. If mashed, cooked and mix with other ingredients it becomes an ultra-transformed food product.

1/ processed id est transformed food products are not cheap...

https://www.theguardian.com/food/2020/feb/13/how-ultra-processed-food-took-over-your-shopping-basket-brazil-carlos-monteiro

2/ processed foods are deleterious to your health.

https://www.theguardian.com/food/2022/aug/31/highly-processed-food-consumption-risk-disease-evidence

Nova classic action of transformed/processed foods

https://www.bmj.com/content/378/bmj-2022-070688?fbclid=IwAR002Z66EaYwbRmKKEjnZ0BfCrbOZ392AFGIcII7vkOPUAvZ8cB-4H0fGUk

A cookbook for paleo diet

https://sa.nutriintervention.com/the-cookbook?fbclid=IwAR1pHjec3clPX5rmMDAleacsE4-9qlK4-iT9U8vUJNwyWuPxZ3SityjoUBg

Pork and mushrooms, home cooking of raw foods

 

Gauby wines

 

Calce 66

Bullet coffee: could it be inappropriate for the brain?

https://www.jci.org/articles/view/149371

However, it is favourable for your metabolism. Low carb diet maintains low insulin and leans toward lipid catabolism to meet energy demand.
Perhaps tea affects less the metabolism of non-neuronal cells. 
Tea with butter as Mongolian people drink is perhaps the best combination (https://www.eater.com/2016/8/25/12624068/butter-coffee-tea-tibet-yak).

https://www.nature.com/articles/d41586-022-01487-4?utm_source=Nature+Briefing&utm_campaign=4e7292f95e-briefing-dy-20220811&utm_medium=email&utm_term=0_c9dfd39373-4e7292f95e-46366554 

TMAO: does this new cohort study add something about causality?

 https://www.sott.net/article/470730-Nina-Teicholz-The-latest-study-on-red-meat-heart-disease-a-red-herring

Association studies in nutrition with a weak difference in RR are generally of poor or no value.

Metabolic health

 https://www.gq.com/story/why-metabolic-health-is-the-key-to-aging-well?fbclid=IwAR1CaHUOM_ci2n-tWtQ9C3HW7azLKwpobagS7heYXGD8BPv0cRZK-eM6SYo&fs=e&s=cl

Outdoors 

Sun

Fresh air

Paleodiet type that is more Pesci vegetarian with some cheeses

Non exhausting workouts of several activities including games

Family

Meditating, writing 

Low carb diet in French

 https://www.youtube.com/watch?v=jjeva-D2nak

The cycle of caffeine dehydration

I have observed that caffeine dehydration is cycling. 3-4 mornings beginning with a 200ml coffee and you dip in dehydration if you don't hydrate without taking into account your thirst.


The second point is that you can break this cycle by replacing coffee with green tea every 3 mornings.

Your brain on vegan diet: weigh the benefit and the risk

 https://www.diagnosisdiet.com/full-article/micronutrients-and-mental-health

https://www.psychologytoday.com/us/blog/diagnosis-diet/201709/the-vegan-brain?fbclid=IwAR2OldFEZkqrSPM5YLNCJwqu_lnCHcJ2JGkCXi6zl9x7g5XFvh8VOTM37yw

Eat oysters only with butter!

https://www.dietdoctor.com/authors/dr-georgia-ede-md 

Grass Fed meat either beef or lamb

https://www.businessinsider.com/grass-fed-claims-beef-bogus-usda-packaging-2016-2?r=US&IR=T

Food addiction

 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117959

Cheese completely fermented raw milk

 

Excellent dairy product, perfectly low carb.

La soupe de légumes aux poissons et aux sulfites

 

Tout y est, Provence, Saint Tropez, Artisanat, mais voilà il faut lire les étiquettes. La communication est réussié mais la recette beaucoup moins. 
.

Et tout se gâte, c'est en fait une soupe de légumes aux daurades et aux sulfites. Une soupe de poissons avec moins de 50% de poissons n'est pas une soupe de poissons... Des sulfites partout qui sont à l'origine de céphalées chez des personnes prédisposées (https://www.nature.com/articles/s41430-019-0420-2). 

This is one major dysnutrition

 

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00222-0 

In this diagram there is a bias: cheeses (the true ones) are high-fat completely fermented dairies. There is no evidence that they increase inflammatory response or bear a carcinogenic potential. Another bias is to consider dried meat as a processed one. It isn't. Dried meat is a natural product.

Immunity: time matters and micronutrients too

 

Perspective: Role of micronutrients and omega-3 long-chain polyunsaturated
fatty acids for immune outcomes of relevance to infections in older adults – a
narrative review and call for action
Manfred Eggersdorfer1*


; Mette M. Berger2


; Philip C. Calder3


; Adrian F. Gombart4
;


Emily Ho5


; Alessandro Laviano6


; Simin N. Meydani7

1 Vitamin D or OH D3 (Cod liver or supplementation)
2 Vitamin C: rose-hip (Rose Hip is the pulpy and red fruit of Wild Rose) and citruses

3 tuna, herring, salmon, trout, sardines anchovy mackerel or Krill oil

4 UNFILTERED Olive oil 

5 Oysters

6 Brazil nuts

Do lipoprotein particles cause atheroma?

Lipid energy model, atherogenic dyslipidemia versus non-atherogenic lipid particles in lean mass hyper responders
1/ Carb restriction diets contribute to weight loss.
Usually, patients with excess weight have an atherogenic profile of lipoproteins. High TG, and at least above 1,5g/l; low HDL and high LDL. Independently of the glycemic control and HOMA but usually with fasting insulin above 15ng/l. These patients may also have systemic low-grade inflammation.
2/ Carb restriction in lean patients doesn't contribute to weight loss any more or only marginally. But the profile of circulating lipoproteins is different: high HDL and low TG. 
Concerning LDL some patients present a high number of LDL cholesterol and the size of their lipoprotein particles is rather large and buoyant. In a group of high responders, the LDL is very high >3g/l. 
(https://mdpi-res.com/d_attachment/metabolites/metabolites-12-00460/article_deploy/metabolites-12-00460.pdf?version=1653050355) 

Do this high number and weight of LDLc lead to the same risk of atheroma?
If there is no smoking, no glycation, no high pollution, no hypertension and no infectious cause of vasculitis it seems that such hyper LDL is not atherogenic. Indeed if the vascular inner lining is safe no breach of this barrier occurs even with shear stress.
So the paradoxical observation that carbohydrate restriction leads to high HDL and LDL emphasizes that atheroma is before all a vasculitis with a disruption of the inner barrier of vessels.

Modèle d'énergie lipidique, dyslipidémie athérogène versus particules lipidiques non athérogènes chez les hyperrépondeurs de masse maigre

1/ Les régimes de restriction en glucides contribuent à la perte de poids.

Habituellement, les patients en surpoids ont un profil athérogène des lipoprotéines. TG élevé, et au moins supérieur à 1,5g/l ; HDL faible et LDL élevé. Indépendamment du contrôle glycémique et de l'HOMA mais le plus souvent avec une insuline à jeun supérieure à 15ng/l. Ces patients peuvent également présenter une inflammation systémique de bas grade.

2/ La restriction en glucides chez les patients maigres ne contribue plus ou seulement de manière marginale à la perte de poids. Mais le profil des lipoprotéines circulantes est différent : HDL élevé et TG bas.

Concernant le LDL certains patients présentent un taux élevé de cholestérol LDL et la taille de leurs particules de lipoprotéines est plutôt grande et flottante. Dans un groupe de hauts répondeurs, le LDL est très élevé >3g/l.

(https://mdpi-res.com/d_attachment/metabolites/metabolites-12-00460/article_deploy/metabolites-12-00460.pdf?version=1653050355)

Ce nombre et ce poids élevés de LDLc entraînent-ils le même risque d'athérome ?

S'il n'y a pas de tabagisme, pas de glycation, pas de forte pollution, pas d'hypertension et pas de cause infectieuse de vascularite il semble qu'un tel hyper LDL ne soit pas athérogène. En effet, si la paroi interne vasculaire est sûre, aucune rupture de cette barrière ne se produit même avec une contrainte de cisaillement.

Ainsi le constat paradoxal que la restriction glucidique entraîne des HDL et LDL élevés souligne que l'athérome est avant tout une vascularite avec une rupture de la barrière interne des vaisseaux.

Sugar ads

They won the PR and communication war.


https://rarehistoricalphotos.com/sugar-vintage-ads/?fbclid=IwAR3afirxKFmtkOC6nnG4JQQXhOhLFDEh1NjOkGa5w1bCU-OC51acHCXomo4 

Sugar is the fast energy you don't need.

From the early 1950s until the 1970s, sugar was marketed as a healthy substance that would help curb hunger and provide an energy boost. This form of advertisement began when health researchers were spreading the news that sugar was connected to weight gain. As a response to this “negative” news, the sugar industry upped its advertising budget. More pro-sugar vintage ads: https://bit.ly/3PILRWb

Fats

 https://www.fatsoflife.com/ 

Illusion du dessert en dernier: cela ne bloque pas le pic glycémique de la confiture à 60% de sucre

"Un repas peut avoir un impact complètement différent sur le glucose en fonction de l'ordre dans lequel on mange les aliments"

Cette affirmation n'a aucun sens. Différent? Ouais mais en biologie une différence de 1 pour mille et de 80% cela ne se rapporte pas de la même façon.
Les différences en rapport avec l'ordre sont faibles. Pourquoi?
Parce que la molécule de glucose est probablement le macronutriment le plus diffusible et absorbable passivement sur tout le Tube Digestif.

Donc jamais un changement d'ordre ne va régler le pb de la charge glycémique excessive chez les D2 et chez les BMI normaux.

Roquefort

A late neolithic raw food from marvellous caves

 

Le lait et les faussaires de l'industrie soutenus par l'idéologie végan

Le plus grand fake autorisé par les agences gouvernementales: appeler lait ce qui n'est pas un lait. Un triomphe du véganisme idéologique.

Le lait est un liquide sécrété par les mamelles des mammifères.

La peinture blanche non plus n'est pas du lait.

#DGCCRF 

#EFSA
https://european-union.europa.eu/institutions-law-budget/institutions-and-bodies/institutions-and-bodies-profiles/efsa_fr 

Vin: Bretèche Bourgueil

 

Peu d’histamine et de sulfites: pas de céphalées

Dégustation agréable
Merci Michèle

16 Mai 2018

Magnesium

Reffelmann et al. Low serum magnesium concentrations predict cardiovascular and all-cause mortality. Atherosclerosis 219:280-4, 2011 LINK

Larsson et al. Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies. Am J Clin Nutr. 95:362-6, 2012 LINK

Chiuve et al. Plasma and dietary magnesium and risk of sudden cardiac death in women. Am J Clin Nutr. 93:253-60, 2011 LINK

Chiuve et al. Dietary and plasma magnesium and risk of coronary heart disease among women. J Am Heart Assoc. 18; 2:e000114, 2013 LINK 
Ochsenham, Peter; Vormann, Professor Juergen. The Magnesium Deficiency Crisis: Is This the Worlds Number One Mineral Deficiency? (p. 84). madhouseMEDIA. Kindle Edition. 

Anis

 

Anisette
https://www.gmtaieb.com/anisette-phenix 

Health improvements are not costly, it is the contrary

https://www.outsideonline.com/health/wellness/biochemists-advice-wellness/?fbclid=IwAR2dw7_cZ_lfwCGMEbGCqjh2rKbT4m8OkrgRGfQ18wN9Zp28PUhNRV3XnY8&utm_campaign=&utm_content=&utm_medium=organic-social&utm_source=Outside%20Magazine-facebook

I suppose that you did the primary step. 

Stop alcohol, inhaling toxic fumes and any drugs.

Some important pieces of the health puzzle when you age.

Low carb, whole food, paleo-inspired diet all time. A pesco-vegetarian diet is fundamental, it means meat or organs two to three times a week only.

Reset your cell survival genetic mechanisms by aleatory fasting. A great beginning is to skip a meal or replace it with broth, salted and full of flavours. Whether you fast or not think that water is available ad libitum and that usually, you are rather under-hydrated.

Exercise according to your feelings but most often outside, sunlight is fundamental, breathing deeply also. Exercise should have to be funny. Some social gatherings during exercise are favourable.

Supplements? No need except if a deep deficiency is discovered: D and some whey protein could be useful. Take pure D vitamin of medical quality. Whey protein should be sugar-free and without any flavour (you can choose your own flavours like mixing some raw cocoa or raw blueberries or some butter or crème fraîche).  Other supplements are unbacked by clinical evidence and could be harmful.

Je suppose que vous avez fait la première étape.

Arrêtez l'alcool, l'inhalation de vapeurs toxiques et de toute drogue.

Quelques pièces importantes du puzzle de la santé lorsque vous vieillissez.

Faible teneur en glucides, aliments entiers, régime d'inspiration paléo à tout moment. Un régime pesco-végétarien est fondamental, c'est-à-dire de la viande ou des abats deux à trois fois par semaine seulement.

Réinitialisez vos mécanismes génétiques de survie cellulaire par un jeûne aléatoire. Un bon début est de sauter un repas ou de le remplacer par un bouillon, salé et plein de saveurs. Que vous soyez à jeun ou non pensez que l'eau est disponible à volonté et que d'habitude, vous êtes plutôt sous-hydraté.

Faites de l'exercice selon vos sensations mais le plus souvent à l'extérieur, la lumière du soleil est fondamentale, la respiration profonde aussi. L'exercice doit être amusant. Certains rassemblements sociaux pendant l'exercice sont favorables.

Suppléments ? Pas besoin sauf si une carence profonde est retrouvée : D et quelques protéines de lactosérum pourraient être utiles. Prenez de la vitamine D pure de qualité médicale. La protéine de lactosérum doit être sans sucre et sans aucune saveur (vous pouvez choisir vos propres saveurs comme mélanger du cacao cru ou des myrtilles crues ou du beurre ou de la crème fraîche). D'autres suppléments ne sont pas étayés par des preuves cliniques et pourraient être nocifs.

Paleo, low carb or keto diets: what are the available evidence?

 https://www.livescience.com/paleo-diet-vs-keto-the-difference-explained

Insulin, sugars and chronic diseases

https://www.linkedin.com/pulse/sugar-well-fructose-specifically-kills-heres-how-foods-ranney-/?fbclid=IwAR1RMf05YESdqEucDEyPqXtbVjgpnCECaCZQmg2q9x9lrE5AKkLKjexL4HU 

Are you sufficiently hydrated after you workout? Try the Delay to pee

 If you pee at the end of your workout you are probably well compensated in water

If you don’t pee in the 30 minutes after it you are lacking water and probably minerals.

Second point to check: the volume

Third: the color 

Toes, wide forefoot, shoes, running, toe spreader and toe socks

 https://www.outsideonline.com/outdoor-gear/hiking-gear/toe-socks-thru-hiking-footwear-trend/?utm_campaign&utm_content&utm_medium=organic-social&utm_source=Outside+Magazine-facebook&fbclid=IwAR18yI-i2tUsHdPECKItJrWIGPjUdhqCubldDwYukiyMOfcO1pPIg7Du8l4

MS and ketogenic diet

 https://www.aan.com/PressRoom/Home/PressRelease/4962?utm_source=facebook&utm_medium=organic%20social&fbclid=IwAR3pS9wrTA-IIAvEmxdPNR3ZHQi8OoUxoVR3Dv_ZCEBKSQFkGnIl-BNkPoM

The comprehensive basic treatment of autoimmune diseases

 Scholars have, however, made estimates based on the US prevalence of autoimmune diseases based on published papers and primary data collected from smaller countries that have excellent epidemiological resources (such as the Scandinavian countries). These estimates suggest that all autoimmune diseases combined affect about 3% of the US population, thus approximately 10 million people. To put this estimate into perspective, look at the table below based on the current US population of 329 million.

https://pathology.jhu.edu/autoimmune/prevalence

Disease	Prevalence as % of population
Obesity	35%
All cardiovascular diseases	20%
Type 2 diabetes mellitus	15%
All cancers	4%
All autoimmune diseases	3%

Avoid the triggers

https://www.mdpi.com/1873-149X/28/4/34 

Gluten

https://academic.oup.com/nutritionreviews/article-abstract/80/3/525/6335547

Lentils, soja,

Lectins, PHA are immune stimulants

https://pubmed.ncbi.nlm.nih.gov/10884708/ 

https://www.hindawi.com/journals/jir/2020/1438957/

Reverse the W3/W6 ratio concerning the long PUFA

https://www.bmj.com/content/376/bmj-2021-066452 

Pescovegetarian diet

BTW the diet of centenarians 

Optimize the vitamin D supply

https://www.bmj.com/content/376/bmj-2021-066452

Sun exposure, fatty fishes and supplements 

https://www.sciencedirect.com/science/article/pii/S1568997219301508?via%3Dihub 

More favourable in W than in M.
https://bsd.biomedcentral.com/articles/10.1186/s13293-021-00358-3

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263069