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lundi 31 mars 2014

Pollan and paleodietS

Concentrated sugar, pure sugar, refined starches

Med diet and blood markers of atherosclerosis

Two important questions about high prot diets

Sat fats debate: the NYT paper

Fish: an example of food choice based upon a ratio of B/R

Sport: what sport?

You don't need Ghee, eat raw butter instead

mercredi 19 mars 2014

More on what our ancestors did actually eat

La nouvelle transition: participer et choisir son traitement

C'est exactement ce que nous vivons chque jour avec nos patients.

Intéressant au moins pour l'analyse des médias médicaux français et mondiaux

Le film d'Arte:

Even small or short duration doses of antibiotics are driving bacterial resistance: that's the main interest of organic farming for global health

Source:, Antibiotic Resistance Threats in the United States, 2013 

Egg washing: beneficial or deleterious?

"Hence, appropriate attention is essential to make sure eggs are kept at appropriate storage and drying conditions so that they will not come in contact with Salmonella after washing."

mardi 18 mars 2014

You need to know the significance of a genomic term?

A highly predictable consequence of religious practice of veiling: osteoporosis


Every day patients ask me the question:
What kind of diet? Obviously I will eat less fat but what else?
And every day i have to explain that fat is not the problem.

Integrative approach of pro-atheroma metabolism: the link between CHO, Fatty acids and inflammation

Full-size image (79 K)
Factors determining SFA status and which thereby may ultimately contribute to chronic systemic low-grade inflammation and atherogenic lipidemia. A high fiber intake may increase gram-positive Firmicutes, resulting in a higher production of SCFAs, which together support gut integrity and may decrease LPS uptake [50] and [51]. High-fat diets, especially those rich in SFA, have been shown to increase LPS uptake in the gut [52] and [53], and LPS has been associated with inflammation via the activation of TLR4 [54]. A high CHO intake induces DNL and the production of SFA, while it also causes the sparing of dietary SFA. DNL is also stimulated by insulin resistance, the metabolic syndrome, nonalcoholic fatty liver disease/nonalcoholic steatohepatitis, high-GL foods, fructose and alcohol [49]. A high SFA status may cause inflammation via the activation of TLR4 and TLR2, ceramide production and formation of lipid rafts. More recently, fetuin A, a liver-derived circulating glycoprotein, has been shown to serve as an adaptor protein that directly links SFA to TLR4 activation and promote lipid-induced insulin resistance [55] and [56]. Excessive storage of SFA in adipose tissue may cause high free SFA during insulin resistance and upon fasting and thereby contribute to inflammation. Inflammation induces adaptations in metabolic (e.g., insulin resistance), hormonal (e.g., reduced insulin sensitivity, up-regulation of the hypothalamus–pituitary–adrenal axis, down-regulation of the hypothalamus–pituitary–gonadal axis) and nervous pathways (e.g., sympathetic nervous system activation), which are jointly meant for the reallocation of energy-rich nutrients that spare glucose for the brain and immune system and force other organs to use lipids for energy generation[14]. Among these changes, we find alterations in lipoprotein metabolism (high TG, high free fatty acids, low HDL) and in cholesterol homeostasis (low HDL, small dense LDL, “dysfunctional’ HDL), which are jointly known as the “atherogenic lipid profile.” All of these adaptations aim at the short-term redistribution of energy and modulation of the inflammatory reaction and the repair of the damage produced by the immune system, but in the long run will cause the metabolic syndrome and its associated diseases. Whether SFA plays a relevant contributing role in the development of chronic systemic low-grade inflammation (the central factor in this pathophysiological cascade) is dependent on many other factors that contribute to inflammation or its inhibition. Among the inflammatory factors are lack of exercise, high dietary ω6/ω3 ratio, chronic stress, anxiety and depression, air pollution (smoking included) and insufficient sleep. Anti-inflammatory factors are, e.g., physical exercise, fish and fish oil, high fruits, vegetables and fiber, low-GL foods, low psychosocial stress and adequate sleep [13].

Another blow to current guidelines about atheroma prevention

And take time to look at these absolute results:

This paper invalidates the link between LDL cholesterol and mortality hazard in patients with chronic heart failure.

Meat and nutrition science: when and what meat is bad for you

Fresh food consumption

Not actually good news for Europe

Lingonberry/cowberry/airelle rouge + Omega 3 longue chaine dans l'hypertension

Une aide substantielle dans l'hypertension sel dépendante.

Les acides gras omega 3 longue chaine (huile de poisson et de Krill) sont efficaces dans l'HTA en général.

Cancer in the past

"Cancer, one of the world’s leading causes of death today, remains almost absent relative to other pathological conditions, in the archaeological record, giving rise to the conclusion that the disease is mainly a product of modern living and increased longevity. This paper presents a male, young-adult individual from the archaeological site of Amara West in northern Sudan (c. 1200BC) displaying multiple, mainly osteolytic, lesions on the vertebrae, ribs, sternum, clavicles, scapulae, pelvis, and humeral and femoral heads. Following radiographic, microscopic and scanning electron microscopic (SEM) imaging of the lesions, and a consideration of differential diagnoses, a diagnosis of metastatic carcinoma secondary to an unknown soft tissue cancer is suggested. This represents the earliest complete example in the world of a human who suffered metastatic cancer to date. The study further draws its strength from modern analytical techniques applied to differential diagnoses and the fact that it is firmly rooted within a well-documented archaeological and historical context, thus providing new insights into the history and antiquity of the disease as well as its underlying causes and progression."

lundi 17 mars 2014

Endocrine disruptors are not friendly chemistry

Low carb in met syndrome and the heart

Is there any peer at the cell metabolism committee who reads slideshare?

Lait bio

Une des plus importantes recommandations que l'on pourrait faire au sujet du lait bio est de ne pas consommer de lait ecreme ou demi ecreme.
En effet un des avantages du mlait bio est la présence d'omega 3 dus à la consommation d'herbe et de fourrage. Mais aussi de CLA un acide gras particulier issu de la rumination de la cellulose de l'herbe qui est favorable à l'équilibre du sucre et au maintien d'un poids normal.
Mais il y a d'autres recomandations.

Agave syrups are fructose! Even organic ones!

"There's a significant difference between agavins and the agave syrup and nectar that are marketed as an alternative to sugar, López explained. Those agave products are made of fructans that have been broken down into individual fructoses and are similar to high-fructose corn syrup, she said."

Saturated fats and atheroma

It's a complex and dynamic issue. 1/ With time the amount of cheap calories from processed foods ingested has increased significantly all over the world. This increase depends on GDP/hab, food production, availability, subsidies and prices. At the present time refined cereals and starches are the most important contributors to this increase in calorie intake. Nevertheless in the same time sat fats consumption slightly decreased or remained unchanged. 2/ During the last century people sat and all physical exertions were drastically reduced by motors leading to a very positive calorie balance. 3/ During the same period of time we increased W6/W3 ratio mainly because of advises which favored veg oils. This have an impact on our chronic inflammatory potential. 4/ Progressively we identified trans fats as the most potent atherogenic fat. And BTW we revised our precedent data about sat fats and atheroma. 5/ One must not forget that we are not equal in front of atheroma. The prevalence of CHD which is a very reliable index of atheroma is widely distributed all over the world and even in EU! Finland Scotland have a very high prevalence and France a very low one despite a high consumption of sat fats. So sat fats are not the culprit. They could add a risk but largely below - central obesity (W/H ratio) - smoking - Hypertension. Why? because sat fats (an heterogeneous set of fatty acids) increase both HDL and LDL levels and some of them only LDL. This atherogenous effect is negligible when CHD and atheroma has a low prevalence but is of significant importance when the prevalence is high. On a personal basis it is the same, it's negligible if the risk equation shows a low risk situation it's significant if the patient is at high risk. And eventually one must keep in mind that lives can be easily saved by tackling the main risk factors of atheroma I mentioned previously instead of focusing on sat fats and push the patient in the sugar or W6 excesses..

vendredi 14 mars 2014

Crohn's disease

Immunity and gluten free diet in non celiac patients

Breakfast variant

Don't forget to chew foods

Full-size image (72 K)
Changes in postprandial hunger (A), fullness (B), desire to eat (C), and thirst (D) ratings during the slow and fast eating conditions in 35 normal-weight (NW) and 35 overweight/obese (OW/O) subjects. The values are means and standard deviations. There was no eating condition by weight status interaction effect for any of the appetite or thirst ratings as evaluated by a mixed-model repeated measures analysis. In both the NW and OW/O groups, there was a significant eating condition by time effect (P=0.001 or less) for hunger, fullness, desire to eat, and thirst. Hunger ratings (A) by eating condition were significantly different at 5 (P<0 .0001="" 10="" span="">P<0 .0001="" 15="" span="">P<0 .0001="" 60="" and="" span="">P=0.01) minutes in the NW group and at 5 (P<0 .0001="" 10="" span="">P<0 .0001="" 15="" span="">P=0.0001), 20 (P=0.003), and 60 (P=0.03) minutes in the OW/O group as assessed by least squares means. Fullness ratings (B) by eating condition were different at 5 (P<0 .0001="" 10="" span="">P<0 .0001="" 15="" span="">P<0 .0001="" 30="" span="">P=0.04), 45 (P=0.01), and 60 (P=0.02) minutes in the NW group and at 5 (P<0 .0001="" 10="" span="">P<0 .0001="" 15="" span="">P=0.0001), and 20 (P=0.003) minutes in the OW/O group. Desire to eat ratings (C) by eating condition were different at 5 (P<0 .0001="" 10="" span="">P<0 .0001="" 15="" and="" span="">P<0 .0001="" 5="" and="" at="" group="" in="" minutes="" nw="" span="" the="">P<0 .0001="" 10="" span="">P<0 .0001="" 15="" span="">P<0 .0001="" 20="" span="">P=0.0003), and 25 (P=0.04) minutes in the OW/O group. Thirst ratings (D) by eating condition were different at 10 (P=0.02), 45 (P=0.03), and 60 (P=0.04) minutes in the NW group at 10 minutes (P=0.008) in the OW/O group.

jeudi 13 mars 2014

Urgent: ketosis against cancer

Alimentation paléo méditerranéenne

Livraison de viande à l'herbe. Sans oublier les os, le foie.

Saveurs du pays catalan, une viande de demi  montagne en élevage extensif.

Exercise and work out series (2): do you need to run?

Environmental pollution and sea food: a critical appraisal

Exercise and work out series (1): push up variations

Industrial farming: questions about the nutritional value of meat

mercredi 12 mars 2014

Genomics of obesity

Fatty acids in the maternal diet and the fate of offspring

Another failure of dietary supplements: glucosamine

One paper a day, LDL and atheroma: do patients with familial hypobetalipoproteinemia have better risk profile? Do they have less atheroma?

"Cardiovascular Risk

Numerous studies have established a strong correlation between levels of LDL cholesterol and progression of IMT.44 In the present study, however, we could not show an independent statistical difference in terms of carotid IMT values between FHBL subjects and controls. Nevertheless, data have accumulated recently that show the predictive value of the assessment of vascular function, such as arterial stiffness, for future cardiovascular events.23,45–48 Arterial stiffness is closely correlated with increasing age, smoking, and hypertension.31,32,49–51 The impact of these risk factors is augmented in the presence of hypercholesterolemia and can be reverted by statin therapy.52,53 In our FHBL group, we observed a significant decrease in arterial stiffness. Of note, this difference was observed despite the fact that traditional risk factors such as smoking and diabetes occurred more frequently in the FHBL group compared with controls. In earlier studies, apoB-containing lipoproteins have been put forward as a pivotal “permissive” factor for the development of atherogenic changes of the vessel wall. To evaluate a potential interaction between apoB-containing lipoproteins and other traditional risk factors, we constructed a cumulative risk index including age, smoking, and systolic blood pressure in FHBL subjects as well as controls. In both groups, there was a linear relationship between increased risk score and arterial stiffness. Interestingly, the increase in arterial stiffness, also in presence of these risk factors was decreased significantly in the FHBL group compared with controls. These data suggest that apoB-containing lipoproteins indeed have the ability to potentiate the impact of traditional risk factors on vascular function. Tentatively, these observations might suggest that lowering of apoB-containing lipoproteins should have a beneficial impact also in subjects with “noncholesterol” risk factors. Recent studies have validated the beneficial effects of statin therapy in normocholesterolemic subjects with nonlipid risk factors, such as hypertension.54

This study has some limitations. We used the less sensitive ultrasonography method to evaluate fatty liver disease rather than magnetic resonance spectroscopy. However, in view of the carefully standardized methodology and the fact that both patients and controls were evaluated using the same methodology, it is unlikely that the latter has affected our outcomes. With regard to the IMT measurement, we could not find a clear relationship between LDL cholesterol levels and carotid IMT. Several reasons may have attributed to the absence of a relation. First, we studied a relatively young cohort with an inherently low risk for cardiovascular disease and hence low IMT values. Second, we studied IMT in a case control design to show thinner IMTs compared with healthy controls. A priori, it is very difficult to demonstrate decreased IMT thickness in “low-risk” groups compared with healthy controls. We have estimated that inclusion of more than 1000 subjects per group would have been necessary to be able to detect significantly thinner IMTs compared with healthy controls with a “normal” risk factor distribution, as seen in western populations.

In summary, our study shows that subjects with FHBL are at increased risk of developing FLD. Whereas long-term sequelae of FLD in FHBL subjects remain to be established, it is prudent to give lifestyle advice in affected individuals. As is illustrated by decreased vascular wall stiffness, our findings suggest that the vessel wall in FHBL subjects is relatively protected by the (life-long) reduced levels of exposure to apoB-containing lipoproteins. The attenuated gradual increase in vascular stiffness in the presence of classical, nonlipid cardiovascular risk factors in FHBL subjects is of interest and suggests that apoB-containing particles constitute a central factor in atherogenesis, amplifying any risk mediated by nonlipid risk factors. Further confirmation of this finding is needed in larger cohorts to ascertain its impact on cardiovascular risk."

Figure 2. Arterial stiffness versus cumulative risk score in FHBL. The cumulative risk score is based on 3 variables: age, smoking, and systolic blood pressure (SBP). Results of each variable, except for smoking, were divided into tertiles. For age and SBP, patients received scores of 1, 2, or 3 with each increasing tertile. Smoking was scored as either 0 for nonsmoking or 3 for smoking. Minimal and maximal attainable scores were 2 and 9, respectively. The probability value indicates the difference in slope between the 2 regression lines.

The only conclusion we can draw from this paper is that ApoB 100 deficient humans have not more atheroma in the carotid than controls.
One can speculate that ApoB 100 is not the culprit and that at least it is not sufficient to have ApoB 100 lipoprotein (id est LDL particles) to build plaques in the artery wall.

More about saturated fats

Obesity is a brain disease caused by junkfood

Nutrition and models of computational biology

lundi 10 mars 2014

Clinical study on low carb diet and cancer

Coconut oil

Go raw

Whey + sweet potatoe ?

The salt debate: industry and regulators too slow and too soft on reduction

L'amidon est un train de glucose

Il est très important de comprendre que l'amidon est un sucre en chaine. Ensuite il faut simplement oublier la notion de sucre lent et de sucre rapide.
Les différentes familles d'amylaces
Blé tendre
Blé dur
Pomme de terre
Patate douce
Pois chiche

Allium sativum

dimanche 9 mars 2014

Antibiotics: X factor of human obesity and obesity?

Here is a very provocative paper which emphasizes the need for less use of ATB in cattle ans humans.

So ATB is a growth factor for farm animals I mean chicken, veals etc.
What about humans?

"After raising chicks on Aureomycin-laced food and on ordinary mash, he found that the antibiotics did boost the chicks’ growth; some of them grew to weigh twice (the bold types are mine) as much as the ones in the control group."

" In fact, a number of scientists believed that antibiotics could stimulate growth in children. "

"In 1954, Alexander Fleming — the Scottish biologist who discovered penicillin — visited the University of Minnesota. His American hosts proudly informed him that by feeding antibiotics to hogs, farmers had already saved millions of dollars in slop. But Fleming seemed disturbed by the thought of applying that logic to humans. “I can’t predict that feeding penicillin to babies will do society much good,” he said. “Making people larger might do more harm than good.”"

And more 
"Mr. Jukes summarized Dr. Carter’s research in a monograph on nutrition and antibiotics: “Carter carried out a prolonged investigation of a study of the effects of administering 75 mg of chlortetracycline” — the chemical name for Aureomycin — “twice daily to mentally defective children for periods of up to three years at the Florida Farm Colony. The children were mentally deficient spastic cases and were almost entirely helpless,” he wrote. “The average yearly gain in weight for the supplemented group was 6.5 lb while the control group averaged 1.9 lb in yearly weight gain.”
Researchers also tried this out in a study of Navy recruits. “Nutritional effects of antibiotics have been noted for some time” in farm animals, the authors of the 1954 study wrote. But “to date there have been few studies of the nutritional effects in humans, and what little evidence is available is largely concerned with young children. The present report seems of interest, therefore, because of the results obtained in a controlled observation of several hundred young American males.” The Navy men who took a dose of antibiotics every morning for seven weeks gained more weight, on average, than the control group."

Very disturbing:
" What happens when chocolate doughnuts mix with penicillin?The results of the study were dramatic, particularly in female mice: They gained about twice as much body fat as the control-group mice who ate the same food. “For the female mice, the antibiotic exposure was the switch that converted more of those extra calories in the diet to fat, while the males grew more in terms of both muscle and fat,” Dr. Blaser writes. “The observations are consistent with the idea that the modern high-calorie diet alone is insufficient to explain the obesity epidemic and that antibiotics could be contributing.”"

Cesarean section: a way to obesity?
"Children born by C-section are more likely to be obese in later life."

More on sat fats and their replacement

samedi 8 mars 2014

Sucre et industrie Graphique 3 - Quantités de glucides simples présentes dans chacun des produits achetés par les ménages

On voit mal ce que font les fruits dans ce tableau...

Med diet in the paleo times

En réalité il n'y a pas un mais des régimes paléo car dans chaque niche écologique, avant le néolithique l'alimentation des humains présentait des caractéristiques particulières.

Au néolithique on assiste à l'introduction progressive des végétaux cultivés notamment les céréales, des animaux d'élevage et des produits laitiers.

Cette transition se fait sur plusieurs siècles et elle a lieu dans le croissant fertile environ 10000 ans  avant notre ère.

Le bassin méditerranéen est manifestement un des endroits de la planète où les humains ont ete en contact très tot dans l'histoire de l'humanité avec les céréales, les gens d'élevage et les produits laitiers.

Wild honey in Nepal

Male centenarians as a marker of longevity diet

vendredi 7 mars 2014

Vitamin D and MS: a brilliant paper

Figure 1
Figure 2

Figure 3
Figure 4

Hypovitaminosis D in infants and todlers

TABLE 2. Serum levels of 25(OH)D vitamin and related
biochemical measurements (before and after treatment, all

Median (25th percentile to 75th
                                             Baseline                                                          After treatment
25(OH)D, ng/ml                    17 (11–19)                                                     36 (23–70)
PTH, pg/ml                           34 (20 –50)                                                    24 (18 –35)
Alkaline phosphatase,U/liter  283 (232–383)                                               269 (211–350)
Calcium, mg/dl                      10.4 (10.1–10.7)                                           10.3 (10.1–10.6)
Magnesium, mg/dl                 2.4 (2.2–2.5)                                                 2.3 (2.2–2.4)

Biscuits bio sans huile de palme: insipides

Un petit conseil au fabricant je crois provençal... Faites donc vos biscuits à l'huile d'olive non filtrée et ils auront du gout. Là pour faire écologiquement correct vous avez remplacé l’huile de palme par l'huile de coco et ils n'ont plus de gout...

Le délire écolo-protectionniste: haro sur l'huile de palme mais silence sur le sucre

Un pain nature? Sans huile palme...
Voyons un peu.
Blé exclusivement français. Le protectionnisme de l'écologie dite de proximité se porte bien, il n'y a aucun intérêt nutritionnel a consommer exclusivement du blé français! Allez vendre du blé hexagonal à l'étranger avec ce type d'emballage protectionniste dans tous les supermarchés français ! N'oublions pas que nous sommes un très gros exportateurs agroalimentaires.
Maintenant allons au cœur de la formule magique du pain soi-disant naturel.

Vous avez tout compris ce pain naturel contient bien sûr de l'huile de colza du sucre du sel un arôme, on a rajouté du gluten de blé au cas ou celui qui est apporté par la farine de blé ne suffirait pas, du vinaigre, de la farine de fève et un extrait d'acerola.
venons en aux faits:
50,7g de glucides pour 100g de pain Harris naturel, dont 5,6g de sucre ajouté
5,0g de graisses dont 0,5g de graisses saturés avec l'huile de colza alors qu'il y en aurait eu toujours 5,0g mais avec 2,5g de graisses saturées en cas d'utilisation d'huile de palme...
8,8g de protéines c'est très peu et pourtant Harris a rajouté du gluten, pas très digeste comme protéine.

C'est vraiment une grosse farce, l'industrie agroalimentaire prend les clients pour des idiots. Il est urgent que l'étiquetage soit plus précis et que les formulations mensongères (naturel), ou négatives (sans huile de palme sans blé étranger, sans colorant...) soient éliminées par des recours de type action de groupe car manifestement la réglementation de la DGCCRF est très insuffisante.

Coffee w/2 packets of sugar = 8 grams of sugar 
Bagel / Doughnut = 6 grams / 10 grams of sugar 

Salad w/4T Caesar dressing = 2 grams of sugar 
Soda (12 oz) = 35 grams of sugar 
Chocolate chip cookie = 5 grams of sugar 
Total = 56-60 grams of sugar

If you add starch which is sugar, you understand why the present glycemic load of SAD is so unsustainable for your pancreas...

jeudi 6 mars 2014

You should evaluate you sugar intake: WHO recently moves on this issue

" The review , by Cape Town-based researchers NP Steyn, NG Myburgh and JH Nel, also compares sugar consumption in malnourished populations of children to that of well-nourished populations. It finds that in many cases sugar displaces protein consumption and significantly dilutes iron, zinc and thiamine intake. This suggests that the diets of undernourished children would not be improved by the addition of sugar-rich foods. "

"New draft guideline proposals

WHO’s current recommendation, from 2002, is that sugars should make up less than 10% of total energy intake per day. The new draft guideline also proposes that sugars should be less than 10% of total energy intake per day. It further suggests that a reduction to below 5% of total energy intake per day would have additional benefits. Five per cent of total energy intake is equivalent to around 25 grams (around 6 teaspoons) of sugar per day for an adult of normal Body Mass Index (BMI)."

"The suggested limits on intake of sugars in the draft guideline apply to all monosaccharides (such as glucose, fructose) and disaccharides (such as sucrose or table sugar) that are added to food by the manufacturer, the cook or the consumer, as well as sugars that are naturally present in honey, syrups, fruit juices and fruit concentrates.
Much of the sugars consumed today are “hidden” in processed foods that are not usually seen as sweets. For example, 1 tablespoon of ketchup contains around 4 grams (around 1 teaspoon) of sugars. A single can of sugar-sweetened soda contains up to 40 grams (around 10 teaspoons) of sugar.
The draft guideline was formulated based on analyses of all published scientific studies on the consumption of sugars and how that relates to excess weight gain and tooth decay in adults and children."