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mardi 26 mai 2015

Fitness myths

Inflammation after damage associated molecular pattern recognition

Lectins and immunity

Stress in the gut after work out

Increasing organic matter in soil

Deadly trade off and unreachable challenge

Brain Development and microbiome

Human remains of Bronze age

Non coeliac gluten sensitivity

Yes this entity does exist and is very difficult to manage.

Why NSAID and/or corticoids should be banned from athletes

Why it is mandatory to check every thing about a "scientific" paper...
This address does not work, nor the others for RM Fleming former cardiologist in Omaha Nebraska USA.
I would have liked to send him some questions about this paper:

Angiology. 2000 Oct;51(10):817-26.

The effect of high-protein diets on coronary blood flow.

Author information

  • 1The Fleming Heart and Health Institute and the Camelot Foundation, Omaha, Nebraska 68114, USA.


Recent research has demonstrated that successful simultaneous treatment of multiple risk factors including cholesterol, triglycerides, homocysteine, lipoprotein (a) [Lp(a)], fibrinogen, antioxidants, endothelial dysfunction, inflammation, infection, and dietary factors can lead to the regression of coronary artery disease and the recovery of viable myocardium. However, preliminary work revealed that a number of individuals enrolled in the original study went on popular high-protein diets in an effort to lose weight. Despite increasing numbers of individuals following high-protein diets, little or no information is currently available regarding the effect of these diets on coronary artery disease and coronary blood flow. Twenty-six people were studied for 1 year by using myocardial perfusion imaging (MPI), echocardiography (ECHO), and serial blood work to evaluate the extent of changes in regional coronary blood flow, regional wall motion abnormalities, and several independent variables known to be important in the development and progression of coronary artery disease. Treatment was based on homocysteine, Lp (a), C-reactive protein (C-RP), triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and fibrinogen levels. Each variable was independently treated as previously reported. MPI and ECHO were performed at the beginning and end of the study for each individual. The 16 people (treatment group/TG) studied modified their dietary intake as instructed. Ten additional individuals elected a different dietary regimen consisting of a "high-protein" (high protein group/HPG) diet, which they believed would "improve" their overall health. Patients in the TG demonstrated a reduction in each of the independent variables studied with regression in both the extent and severity of coronary artery disease (CAD) as quantitatively measured by MPI. Recovery of viable myocardium was seen in 43.75% of myocardial segments in these patients, documented with both MPI and ECHO evaluations. Individuals in the HPG showed worsening of their independent variables. Most notably, fibrinogen, Lp (a), and C-RP increased by an average of 14%, 106%, and 61% respectively. Progression of the extent and severity of CAD was documented in each of the vascular territories with an overall cumulative progression of 39.7%. The differences between progression and extension of disease in the HPG and the regression of disease in the TG were statistically (p<0 .001="" a="" able="" addition="" and="" artery="" as="" both="" but="" cad.="" cai="" coagulation="" coronary="" deposition="" diet="" dietary="" diets="" disease="" each="" extent="" factors="" following="" for="" function="" guidelines.="" high-protein="" however="" improve="" in="" increases="" independent="" individuals="" inflammatory="" lipid="" may="" medical="" motion="" myocardial="" of="" pathways.="" patients="" precipitate="" prescribed="" progression="" receiving="" recommended="" regress="" results="" risk="" same="" severity="" showed="" significant.="" span="" suggest="" that="" the="" their="" these="" through="" to="" treatment="" variables="" wall="" well="" were="" while="" worsening="" would="">

Especially about the type of protein and the type of fats in the study. I was surprised by the Lp(a) burst as we know tha Lp(a) is genetically regulated and could increase only with a high carb diet...
I was surprised twice to discover the fraud...

Should Sage publishing investigate the data of this paper and finally retract it?

Goat's vs cow's milk

Goat 89% less alpha1 casein
10% less lactose

Lauersen in Brit J of Sport Medicine 2014: stretching and other means of prevention of sport injuries

Sat fats versus linoleic veg fat: a reappraisal

Keto Diet in obese

Twin studies and diseases

DOMS and berries

Cherry Juice Targets Antioxidant Potential and Pain Relief

Kuehl K.S. 
Division of Health Promotion and Sports Medicine, Department of Medicine, Oregon Health and Science University, Portland, Oreg., USA


Strenuous physical activity increases the risk of musculoskeletal injury and can induce muscle damage resulting in acute inflammation and decreased performance. The human body’s natural response to injury results in inflammation-induced pain, swelling, and erythema. Among sports medicine physicians and athletic trainers, the mainstays of urgent treatment of soft tissue injury are rest, ice, compression, and elevation (RICE). In order to reduce pain and inflammation, anti-inflammatory agents such as non-steroidal anti-inflammatory drugs (NSAIDs) act on the multiple inflammatory pathways, which, although often very effective, can have undesirable side effects such as gastric ulceration and, infrequently, myocardial infarction and stroke. For centuries, natural anti-inflammatory compounds have been used to mediate the inflammatory process and often with fewer side effects. Tart cherries appear to possess similar effectiveness in treating the inflammatory reaction seen in both acute and chronic pain syndromes encountered among athletes and non-athletes with chronic inflammatory disease. This article reviews the antioxidant and anti-inflammatory effects of tart cherries on prevention, treatment, and recovery of soft tissue injury and pain.

© 2012 S. Karger AG, Basel


Author Contacts

Dr. Kerry S. Kuehl, MD DrPH, Division of Health Promotion and Sports Medicine, Department of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 (USA), Tel. +1 503 494 5991, E-Mail

lundi 25 mai 2015

Do you have Zinc deficiency?


The answer

Obesity related to change of human conditions of life

Never forget that extended life expectancy came with a big side effect: industrially produced, endless available sugars

Glioblastoma and Caloric Restriction low carb diet

We need survival data to recommend such diet. It is of great importance to keep in mind that apart low carb high fat diet patients should be in caloric restriction. This si not easy to manage concomitantly with the conventional treatments.

Denise Minger sums it but you should read the paper at the bottom of the post

This paper and others emphasizes the predominant role of Caloric Restriction.
We cannot recommend LCHF diets on the basis of clinical studies in D2, MS or normal subjects.
It seems more evidence based to recommend CR and med diet with low carb in adults regardless of what they want to improve. 

What is the best trade off for your blood lipid profile?

Small dense LDL are more atherogenic when everything is equal. We don't know if they atherogenic per se or in a multifactorial polygenic model of atheroma.
LDL are particles with hydrophilic molecules outside and lipids (TG, cholesterol esters and other esters) inside. They are produced by the liver. Different parameters are genetic.

The shift from small dense LDL toward large buoyant ones depends mostly of the amount of carbs.

The lowering of LDL at large is more depending on the excess of calories and the excess of carbs and sat lipids.
So what could be the good trade off?

There are very few data to compare clinical advantages of lowering LDL at large and shifting LDL profile...
Rationally one can try the two ways
- avoid excess of calories
- reduce carbs
And check the blood profile with measured LDL and apoB100.

Paleo un article très superficiel

Quelques preuves

Recent research suggests that traditional grain-based heart-healthy diet recommendations, which replace dietary saturated fat with carbohydrate and reduce total fat intake, may result in unfavorable plasma lipid ratios, with reduced high-density lipoprotein (HDL) and an elevation of low-density lipoprotein (LDL) and triacylglycerols (TG). The current study tested the hypothesis that a grain-free Paleolithic diet would induce weight loss and improve plasma total cholesterol, HDL, LDL, and TG concentrations in nondiabetic adults with hyperlipidemia to a greater extent than a grain-based heart-healthy diet, based on the recommendations of the American Heart Association. Twenty volunteers (10 male and 10 female) aged 40 to 62 years were selected based on diagnosis of hypercholesterolemia. Volunteers were not taking any cholesterol-lowering medications and adhered to a traditional heart-healthy diet for 4 months, followed by a Paleolithic diet for 4 months. Regression analysis was used to determine whether change in body weight contributed to observed changes in plasma lipid concentrations. Differences in dietary intakes and plasma lipid measures were assessed using repeated-measures analysis of variance. Four months of Paleolithic nutrition significantly lowered (P < .001) mean total cholesterol, LDL, and TG and increased (P < .001) HDL, independent of changes in body weight, relative to both baseline and the traditional heart-healthy diet. Paleolithic nutrition offers promising potential for nutritional management of hyperlipidemia in adults whose lipid profiles have not improved after following more traditional heart-healthy dietary recommendations.

Cholesterol you eat is not cholesterol you have on your blood lipid particles

jeudi 21 mai 2015

Autoimmunity and NaCl

Childhood obesity and processed food consumption


Last year, the country enacted taxes on sugary beverages and high-calorie packaged snacks, while limiting junk-food advertisements aimed at children. Mexico ranks near the top among Organization for Economic Cooperation and Development countries for overweight populations and Type 2 diabetes. One-third of Mexican children are already considered overweight, according to government statistics.

It is the controversy of the millenium: statins, LDL cholesterol, saturated fats, animal fat and atheroma

Debate about sat fats

jeudi 14 mai 2015

Grassfed cattle is environmently friendly

One of the favored arguments of vegans about meat is not about your health but about the "future of the planet". Despite the fact that most of our predictions as humans revealed wrong about demography, economics, climate or science, they believed that meat production is a very important environmental issue which justifies avoiding meat and cattle production.
This paper explains clearly that they are wrong if cattle are grassfed.

Nat Commun. 2015 Apr 30;6:6995. doi: 10.1038/ncomms7995.

Emerging land use practices rapidly increase soil organic matter.


The loss of organic matter from agricultural lands constrains our ability to sustainably feed a growing population and mitigate the impacts of climate change. Addressing these challenges requires land use activities that accumulate soil carbon (C) while contributing to food production. In a region of extensive soil degradation in the southeastern United States, we evaluated soil C accumulation for 3 years across a 7-year chronosequence of three farms converted to management-intensive grazing. Here we show that these farms accumulated C at 8.0 Mg ha(-1) yr(-1), increasing cation exchange and water holding capacity by 95% and 34%, respectively. Thus, within a decade of management-intensive grazing practices soil C levels returned to those of native forest soils, and likely decreased fertilizer and irrigation demands. Emerging land uses, such as management-intensive grazing, may offer a rare win-win strategy combining profitable food production with rapid improvement of soil quality and short-term climate mitigation through soil C-accumulation.

In the paper Figure 2 shows nicely how rapidly Carbon accumulated in soils with a return to the content of native forest  soils in a decade!

The worst is never certain but ideologized people use it to their aims.

Bee controversy

Wait and see: experimental studies and real life

mardi 12 mai 2015

The corn oil trial by Rose is packed with surprises!

You need vitamin D and you can produce it


Changes in diet management of D2 patients

GMO and agrobacterium

More on med diet

Centenarians longevity and IGF1

lundi 4 mai 2015

Genomics and CVD

Sex gap for insulin resistance partially explained

"At similar BMI levels, women maintain their insulin sensitivity when compared to men despite having higher adiposity9. In this study, we investigated the sex differences in muscle PTEN gene expression, protein content and activity to see if PTEN downregulation is involved in this paradox.
We demonstrate that women have lower muscle PTEN gene expression when compared to men, despite having higher adipose tissue mass. This is coupled with increased inactivation of PTEN protein.
PTEN is a dual protein and lipid phosphatase that interferes with the insulin-signaling pathway via its lipid phosphatase activity. PTEN itself can be inactivated by phosphorylation141516, and this post-translational modification impact PTEN activity. PTEN can autoinhibit itself through S380-385 sites, whereby phosphorylation of S385 leads to the phosphorylation of S380 and Threonine sites, and binding of the COOH tail to the C2 and phosphatase domains, preventing the binding of PTEN to a complex of protein that drive its activity17."

samedi 2 mai 2015

You are not what you eat

Grassfed beef

Longevity and the three DNA

Paleodiet in insulin resistance

Human DNA and history

Hidden sugars

Organic foods

A clear review of high-protein diet

vendredi 1 mai 2015

Invaluable source of data on CR

Yaourts juste pour le plaisir

Pas de réelle différence sur l'échelle de qualité de vie choisie.

The detox myth is very stubborn

Personalized clinical trials

PCSK9: the new debate about reduction of CVD deaths

L'imposture des médiocres

Le Nutella apparemment elle connaît bien! Montant du contrat?