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lundi 17 juin 2013

Early diet is of major importance for future health of your kids


Early Diet Impacts Infant Rhesus Gut Microbiome, Immunity, and Metabolism

Department of Nutrition, §Department of Food Science and Technology, One Shields Avenue,University of California, Davis, Davis, California 95616, United States
 Fonterra Ingredients Innovation, Fonterra Co-operative Group, Private Bag 11029, Fitzherbert Dairy Farm Road, Palmerston North, New Zealand
J. Proteome Res.201312 (6), pp 2833–2845
DOI: 10.1021/pr4001702
Publication Date (Web): May 7, 2013
Copyright © 2013 American Chemical Society
*E-mail: cslupsky@ucdavis.edu. Ph: (530) 752-6804. Fax:(530) 752-8966.

"Epidemiological research has indicated a relationship between infant formula feeding and increased risk of chronic diseases later in life including obesity, type-2 diabetes, and cardiovascular disease. The present study used an infant rhesus monkey model to compare the comprehensive metabolic implications of formula- and breast-feeding practices using NMR spectroscopy to characterize metabolite fingerprints from urine and serum, in combination with anthropometric measurements, fecal microbial profiling, and cytokine measurements. Here we show that formula-fed infants are larger than their breast-fed counterparts and have a different gut microbiome that includes higher levels of bacteria from the Ruminococcus genus and lower levels of bacteria from the Lactobacillus genus. In addition, formula-fed infants have higher serum insulin coupled with higher amino acid levels, while amino acid degradation products were higher in breast-fed infants. Increases in serum and urine galactose and urine galactitol were observed in the second month of life in formula-fed infants, along with higher levels of TNFα, IFN-γ, IL-1β, IL-4, and other cytokines and growth factors at week 4. These results demonstrate that metabolic and gut microbiome development of formula-fed infants is different from breast-fed infants and that the choice of infant feeding may hold future health consequences."

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