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lundi 7 mars 2016

Sugar and lung cancer in non smokers

Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites

  1. Xifeng Wu1,*
+Author Affiliations
  1. 1Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  2. 2Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  1. *Corresponding Author:
    Xifeng Wu, Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Unit 1340, 1155 Pressler Boulevard, Houston, TX 77030. Phone: 713-745-2485; Fax: 713-792-4657; E-mail:


Background: Postprandial glucose (PPG) and insulin responses play a role in carcinogenesis. We evaluated the association between dietary glycemic index (GI) and glycemic load (GL), markers of carbohydrate intake and PPG, and lung cancer risk in non-Hispanic whites.
Methods: GL and GI were assessed among 1,905 newly diagnosed lung cancer cases recruited from the University of Texas MD Anderson Cancer Center (Houston, TX) and 2,413 healthy controls recruited at Kelsey-Seybold Clinics (Houston, TX). We assessed associations between quintiles of GI/GL and lung cancer risk and effect modification by various risk factors. ORs and 95% confidence intervals (CI) were estimated using multivariable logistic regression.
Results: We observed a significant association between GI [5th vs. 1st quintile (Q) OR = 1.49; 95% CI, 1.21–1.83; Ptrend <0 .001="" and="" cancer="" gi="" lung="" risk="" style="border: 0px; font-size: 0.85em; font-style: inherit; font-weight: inherit; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit;" sub="">ac
 (5th vs. 1st Q OR = 1.48; 95% CI, 1.20–1.81; Ptrend = 0.001) and lung cancer risk. We observed a more pronounced association between GI and lung cancer risk among never smokers (5th vs. 1st Q OR = 2.25; 95% CI, 1.42–3.57), squamous cell carcinomas (SCC; 5th vs. 1st Q OR = 1.92; 95% CI, 1.30–2.83), and those with less than 12 years of education (5th vs. 1st Q OR = 1.75; 95% CI, 1.19–2.58, Pinteraction = 0.02).
Conclusion: This study suggests that dietary GI and other lung cancer risk factors may jointly and independently influence lung cancer etiology.
Impact: Understanding the role of GI in lung cancer could inform prevention strategies and elucidate biologic pathways related to lung cancer risk. Cancer Epidemiol Biomarkers Prev; 25(3); 532–9. ©2016 AACR.

For general practitioners:
"smoking cessation, decreased radon exposure, and in patients with significant smoking history, possible enrollment in a lung cancer screening program"

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