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mercredi 16 janvier 2013

You plan to be pregnant? Eat fish and cut sunflower and other W6 veg oils...

You wouls have found this advice previously in this blog...
But this paper is important.


Maternal Plasma Polyunsaturated Fatty Acid Status in Late Pregnancy Is Associated with Offspring Body Composition in Childhood

  1. the SWS Study Group
-Author Affiliations
  1. Medical Research Council Lifecourse Epidemiology Unit (R.J.M., N.C.H., S.M.R., G.N., H.M.I., K.M.G., E.M.D., C.C.), University of Southampton, Southampton SO16 6YD, United Kingdom; Pediatric Endocrinology (R.J.M., J.H.D.), University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton SO16 6YD, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre (K.M.G., P.C.C., C.C.), University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, United Kingdom; and Human Health and Development Academic Unit (K.M.G., P.C.C.), Faculty of Medicine, University of Southampton, Southampton SO16 6YD, United Kingdom
  1. Address all correspondence and requests for reprints to: Professor Cyrus Cooper, MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, United Kingdom. E-mail:


Context: Maternal diet during pregnancy has been linked to offspring adiposity, but it is unclear whether maternal polyunsaturated fatty acid (PUFA) status during pregnancy affects offspring body composition.
Objective: We investigated the associations between maternal plasma n-3 and n-6 PUFA status at 34 wk gestation and offspring body composition.
Design and Setting: A prospective United Kingdom population-based mother-offspring cohort, the Southampton Women's Survey (SWS), was studied.
Participants: A total of 12,583 nonpregnant women were recruited into the SWS, among whom 1987 delivered a baby before December 31, 2003; 293 mother-child pairs had complete measurements of maternal plasma PUFA concentrations in late pregnancy and offspring body composition at both ages 4 and 6 yr.
Main Outcomes Measured: We measured offspring body composition by dual-energy x-ray absorptiometry, yielding fat mass, lean mass, percentage fat mass, and percentage lean mass. Results are presented as β-coefficients for standardized variables, therefore reflecting the SDchange of the outcome for every 1 SD of the predictor.
Results: After adjustment for maternal factors and child factors including height and duration of breast-feeding, maternal plasma n-6 PUFA concentration positively predicted offspring fat mass at 4 yr (β = 0.14 SD/SD; P = 0.01) and 6 yr (β = 0.11 SD/SD; P = 0.04), but there was no association with offspring lean mass at either age (β = 0.005 SD/SD, P = 0.89; and β = 0.008 SD/SDP = 0.81, respectively). Maternal plasma n-3 PUFA concentration was not associated with offspring fat mass at 4 yr (β = 0.057 SD/SD; P = 0.34) or 6 yr (β = 0.069 SD/SD; P = 0.21). Maternal plasma n-3 PUFA status was positively associated with offspring lean mass on univariate analysis (4 yr, β = 0.11, P = 0.06; 6 yr, β = 0.14; P = 0.02); however, this was confounded by a positive association with offspring height.
Conclusions: This observational study suggests that maternal n-6 PUFA status during pregnancy might influence offspring adiposity in childhood.

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