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mercredi 12 avril 2017

Glyphosate: a rational approach of risk and the myth of purity or immaculacy
(in French)
Indeed the Greens share the myth of an immaculate planet and of purity of man before the industrial and chemical revolution. Nothing is more false and far from the truth. In the pre-industrial nature fire and pyrolysis were the most potent carcinogens as are radiations and radioactive minerals.
So the bottom line is to measure clinical effects of molecules issued from organic chemistry.
The idea behind this demonstrative measurement of glyphosate in the urine of nonagricultural workers is to underline that all people are "contaminated" and all comparative clinical studies are baseless... It is a powerful argument for laymen. But indeed it isn't.
Experimentally and more importantly in human studies, glyphosate is not a carcinogen neither at dose measured in agricultural workers nor in food consumers. Clinically if glyphosate was a true carcinogen we should observe more cancers in agricultural workers because dose matters in cancer development.
We are not free of organic molecules like biocides but also drugs and hormones like pill components. It is a concern but this contamination is carefully monitored and especially for glyphosate.
Today human cancers are not dependent on glyphosate consumption. This is the most important difference one must understand, a hazard with a weak or unmeasurable risk does not matter; on the other hand, a hazard confirmed by the measurement of a significant risk for humans should be of concern. Tobacco smoke is the first cause of human cancers and food carcinogens are the second.
Those compounds are known as human carcinogens:
  • Acetaldehyde (from consuming alcoholic beverages)
  • Acheson process, occupational exposure associated with
  • Acid mists, strong inorganic
  • Aflatoxins
  • Alcoholic beverages
  • Aluminum production
  • 4-Aminobiphenyl
  • Areca nut
  • Aristolochic acid (and plants containing it)
  • Arsenic and inorganic arsenic compounds
  • Asbestos (all forms) and mineral substances (such as talc or vermiculite) that contain asbestos
  • Auramine production
  • Azathioprine
  • Benzene
  • Benzidine and dyes metabolized to benzidine
  • Benzo[a]pyrene
  • Beryllium and beryllium compounds
  • Betel quid, with or without tobacco
  • Bis(chloromethyl)ether and chloromethyl methyl ether (technical-grade)
  • Busulfan
  • 1,3-Butadiene
  • Cadmium and cadmium compounds
  • Chlorambucil
  • Chlornaphazine
  • Chromium (VI) compounds
  • Clonorchis sinensis (infection with), also known as the Chinese liver fluke
  • Coal, indoor emissions from household combustion
  • Coal gasification
  • Coal-tar distillation
  • Coal-tar pitch
  • Coke production
  • Cyclophosphamide
  • Cyclosporine
  • 1,2-Dichloropropane
  • Diethylstilbestrol
  • Engine exhaust, diesel
  • Epstein-Barr virus (infection with)
  • Erionite
  • Estrogen postmenopausal therapy
  • Estrogen-progestogen postmenopausal therapy (combined)
  • Estrogen-progestogen oral contraceptives (combined) (Note: There is also convincing evidence in humans that these agents confer a protective effect against cancer in the endometrium and ovary)
  • Ethanol in alcoholic beverages
  • Ethylene oxide
  • Etoposide
  • Etoposide in combination with cisplatin and bleomycin
  • Fission products, including strontium-90
  • Fluoro-edenite fibrous amphibole
  • Formaldehyde
  • Haematite mining (underground)
  • Helicobacter pylori (infection with)
  • Hepatitis B virus (chronic infection with)
  • Hepatitis C virus (chronic infection with)
  • Human immunodeficiency virus type 1 (HIV-1) (infection with)
  • Human papilloma virus (HPV) types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 (infection with) (Note: The HPV types that have been classified as carcinogenic to humans can differ by an order of magnitude in risk for cervical cancer)
  • Human T-cell lymphotropic virus type I (HTLV-1) (infection with)
  • Ionizing radiation (all types)
  • Iron and steel founding (workplace exposure)
  • Isopropyl alcohol manufacture using strong acids
  • Kaposi sarcoma herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8) (infection with)
  • Leather dust
  • Lindane
  • Magenta production
  • Melphalan
  • Methoxsalen (8-methoxypsoralen) plus ultraviolet A radiation, also known as PUVA
  • 4,4'-Methylenebis(chloro- aniline) (MOCA)
  • Mineral oils, untreated or mildly treated
  • MOPP and other combined chemotherapy including alkylating agents
  • 2-Naphthylamine
  • Neutron radiation
  • Nickel compounds
  • N'-Nitrosonornicotine (NNN) and 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)
  • Opisthorchis viverrini (infection with), also known as the Southeast Asian liver fluke
  • Outdoor air pollution (and the particulate matter in it)
  • Painter (workplace exposure as a)
  • 3,4,5,3',4'-Pentachlorobiphenyl (PCB-126)
  • 2,3,4,7,8-Pentachlorodibenzofuran
  • Phenacetin (and mixtures containing it)
  • Phosphorus-32, as phosphate
  • Plutonium
  • Polychlorinated biphenyls (PCBs), dioxin-like, with a Toxicity Equivalency Factor according to WHO (PCBs 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169, 189)
  • Processed meat (consumption of)
  • Radioiodines, including iodine-131
  • Radionuclides, alpha-particle-emitting, internally deposited (Note: Specific radionuclides for which there is sufficient evidence for carcinogenicity to humans are also listed individually as Group 1 agents)
  • Radionuclides, beta-particle-emitting, internally deposited (Note: Specific radionuclides for which there is sufficient evidence for carcinogenicity to humans are also listed individually as Group 1 agents)
  • Radium-224 and its decay products
  • Radium-226 and its decay products
  • Radium-228 and its decay products
  • Radon-222 and its decay products
  • Rubber manufacturing industry
  • Salted fish (Chinese-style)
  • Schistosoma haematobium (infection with)
  • Semustine (methyl-CCNU)
  • Shale oils
  • Silica dust, crystalline, in the form of quartz or cristobalite
  • Solar radiation
  • Soot (as found in workplace exposure of chimney sweeps)
  • Sulfur mustard
  • Tamoxifen (Note: There is also conclusive evidence that tamoxifen reduces the risk of contralateral breast cancer in breast cancer patients)
  • 2,3,7,8-Tetrachlorodibenzo-para-dioxin
  • Thiotepa
  • Thorium-232 and its decay products
  • Tobacco, smokeless
  • Tobacco smoke, secondhand
  • Tobacco smoking
  • ortho-Toluidine
  • Treosulfan
  • Trichloroethylene
  • Ultraviolet (UV) radiation, including UVA, UVB, and UVC rays
  • Ultraviolet-emitting tanning devices
  • Vinyl chloride
  • Wood dust
  • X- and Gamma-radiation

En effet, les verts partagent le mythe d'une planète immaculée et de la pureté de l'homme avant la révolution industrielle et chimique. Rien n'est plus faux et loin de la vérité. Le feu et la pyrolyse sont les agents cancérogènes les plus puissants, tout comme les radiations et les minéraux radioactifs.

Le résultat final est donc de mesurer les effets cliniques des molécules issues de la chimie organique.
L'idée derrière cette mesure démonstrative du glyphosate dans l'urine des travailleurs non agricoles est de souligner que toutes les personnes sont «contaminées» et que toutes les études cliniques comparées sont sans fondement ... C'est un argument puissant pour les laïcs. Mais en effet, ce n'est pas le cas.
Expérimentalement, le glyphosate n'est pas cancérogène ni à la dose mesurée chez les travailleurs agricoles ni chez les consommateurs d'aliments. Cliniquement, si le glyphosate est un véritable cancérogène, nous devrions observer plus de cancers chez les travailleurs agricoles parce que la dose est importante dans le développement du cancer.
Nous ne sommes pas exempts de molécules organiques comme les biocides, mais aussi les médicaments et les hormones comme les composants de la pilule. C'est une préoccupation, mais cette contamination est soigneusement surveillée et surtout le glyphosate.
Aujourd'hui, les cancers ne dépendent pas de la consommation de glyphosate. La fumée du tabac est la première cause et les cancérogènes alimentaires sont les seconds.
Ces composés sont connus comme cancérogènes humains: cf supra.

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