Le gluten et votre cerveau

Les céréales et principalement celles qui contiennent du gluten ont envahi notre alimentation. Sur le plan nutritionnel ces aliments présentent de nombreux effets secondaires au niveau digestif et cérébral. le discours ambiant très idéologisé par le végétarisme véhicule l'idée qu'il s'agirait de la base de notre alimentation. Rien n'est plus faux pendant toute l'histoire de l'humanité à l'exception des 10000 dernières années et surtout des deux derniers siècles nous n'avons pas consommé de céréales, les animaux d'élevage non plus... Il convient donc de reconsidérer les signes digestifs et cérébraux d'une intolérance au gluten.

Biol Psychiatry. 2010 Jul 1;68(1):100-4. Epub 2010 May 14.

Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophrenia.

Dickerson F, Stallings C, Origoni A, Vaughan C, Khushalani S, Leister F, Yang S, Krivogorsky B, Alaedini A, Yolken R.

Source

Stanley Research Program at Sheppard Pratt, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21204, USA. fdickerson@sheppardpratt.org

Abstract

BACKGROUND:

Increased immune sensitivity to gluten has been reported in schizophrenia. However, studies are inconsistent about this association.

METHODS:

The sample of 471 individuals included 129 with recent-onset psychosis, 191 with multi-episode schizophrenia, and 151 controls. Immunoglobulin (Ig)G and IgA antibodies to gliadin and to tissue transglutaminase, and IgG antibodies to deamidated gliadin were measured. Quantitative levels of antibodies in the psychiatric groups were compared with controls. All participants were categorized as to whether their levels of antibodies met standardized cutoffs for celiac disease. HLA DQ2 and HLA DQ8 alleles were detected by real-time polymerase chain reaction.

RESULTS:

Individuals with recent-onset psychosis had increased levels of IgG (odds ratio [OR] 5.50; 95% confidence interval [CI] 2.65-11.42) and IgA (OR 2.75; 95% CI 1.31-5.75) antibodies to gliadin compared with control subjects. Individuals with multi-episode schizophrenia also had significantly increased levels of IgG antibodies to gliadin (OR 6.19; 95% CI 2.70-14.16). IgG antibodies to deamidated gliadin and IgA antibodies to tissue transglutaminase were not elevated in either psychiatric group, and fewer than 1% of individuals in each of the groups had levels of these antibodies predictive of celiac disease. There were no significant differences in the distribution of the HLA DQ2/8 alleles among the groups.

CONCLUSIONS:

Individuals with recent-onset psychosis and with multi-episode schizophrenia who have increased antibodies to gliadin may share some immunologic features of celiac disease, but their immune response to gliadin differs from that of celiac disease.

Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.