lundi 30 septembre 2013

Is antioxidant healthful effects a myth?

http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.1352.html
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Transition toward paleo

I am not a fan of substitution by a food which looks like but this one is valuable 




http://sportiseverywhere.wordpress.com/2013/09/28/en-manque-de-pates-essayez-les-courges-spaghetti/
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vendredi 27 septembre 2013

CO2 and your health: nothing linked to climate change but sugar!

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CO2 and your health: nothing linked to climate change but sugar!

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mercredi 25 septembre 2013

Red meat and diabetes

  1. Pan A, Sun Q, Bernstein AM, et al. Changes in red meat consumption and subsequent risk of type 2 diabetes mellitus: three cohorts of US men and women. JAMA Intern Med. 2013:1-8.
  2. Evans WJ. Oxygen-carrying proteins in meat and risk of diabetes mellitus: Comment on "Changes in red meat consumption and subsequent risk of type 2 diabetes mellitus: three cohorts of US men and women." JAMA Intern Med. 2013:1-2.
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lundi 23 septembre 2013

American Gut Study

http://americangut.org/wordpress/wp-content/uploads/2013/09/module1_Sept_16_small.pdf
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vendredi 20 septembre 2013

Cooking by Hunter gatherers

Yes it seems that they carry pots to cook seafood...
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Statins ans cataract: the issue is primary prevention

http://archopht.jamanetwork.com/article.aspx?articleid=1739520

http://www.medpagetoday.com/Cardiology/Dyslipidemia/41753?

My experience is that it is far more efficient and less risky to modify diet, sedentary habits and stop smoking instead of taking statins or polypill for primary prevention of atheroma.

http://www.medpagetoday.com/Cardiology/Prevention/32739

When a drug has a slight benefit be careful!

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60367-5/abstract

Ebrahim S, Casas JP "Statins for all by the age of 50 years?" Lancet 2012; DOI: 10.1016/S0140- 6736(12)60694-1.
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jeudi 19 septembre 2013

Fruit smoothies: the new threat?

http://www.theguardian.com/society/2013/sep/07/smoothies-fruit-juices-new-health-risk

Just change fruit for veggies!
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mercredi 18 septembre 2013

Sugar a free drug available everywhere

http://www.telegraph.co.uk/news/worldnews/europe/netherlands/10314705/Sugar-is-addictive-and-the-most-dangerous-drug-of-the-times.html
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Funny organic world at Whole Foods

http://m.huffpost.com/us/entry/3895583?utm_hp_ref=fb&src=sp&comm_ref=false
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mardi 17 septembre 2013

Paleodish of today



Tomatoes, red peppers, raw albacore tuna, flowers of broccoli, parsley, olive oil, lemon salt...
Then Mâche salad and orange with crème fraîche épaisse...
Drinking: water and a small glass of Graves 
Ready in 25' in the new flat of my son in Paris
Afternoon: no sleepish state, energy until 6pm etc!
Go paleo!


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lundi 16 septembre 2013

Metabolic effects of sugared drinks

http://ajcn.nutrition.org/content/early/2011/12/26/ajcn.111.022533.full.pdf+html
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More on fructose and Met syndrome


"We are now suffering a huge epidemic of metabolic syndrome... and we can correlate the onset of the epidemic with the increased consumption of sugars,"
"The changes in the wild type mice were brought on by fructose converted from glucose via the polyol pathway, wrote Miguel A. Lanaspa, DVM, PhD, asssistant research professor of medicine at the University of Colorado, and his co-authors.
The polyol pathway is triggered by high serum glucose. When that happens, aldose reductase (AR) metabolizes glucose to sorbitol, which is converted to fructose by sorbitol dehydrogenase."










So is it endogenous fructose, exogenous fructose or both? In humans we don't know but fructose is in the box...

Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome




Abstract


Carbohydrates with high glycaemic index are proposed to promote the development of obesity, insulin resistance and fatty liver, but the mechanism by which this occurs remains unknown. High serum glucose concentrations are known to induce the polyol pathway and increase fructosegeneration in the liver. Here we show that this hepatic, endogenously produced fructose causes systemic metabolic changes. We demonstrate that mice unable to metabolize fructose are protected from an increase in energy intake and body weight, visceral obesity, fatty liver, elevated insulin levels and hyperleptinaemia after exposure to 10% glucose for 14 weeks. In normal mice, glucose consumption is accompanied by aldose reductase and polyol pathway activation in steatotic areas. In this regard, we show that aldose reductase-deficient mice are protected against glucose-induced fatty liver. We conclude that endogenous fructose generation and metabolism in the liver represents an important mechanism by which glucose promotes the development of metabolic syndrome.


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