"We are now suffering a huge epidemic of metabolic syndrome... and we can correlate the onset of the epidemic with the increased consumption of sugars,"
"The changes in the wild type mice were brought on by fructose converted from glucose via the polyol pathway, wrote Miguel A. Lanaspa, DVM, PhD, asssistant research professor of medicine at the University of Colorado, and his co-authors.
The polyol pathway is triggered by high serum glucose. When that happens, aldose reductase (AR) metabolizes glucose to sorbitol, which is converted to fructose by sorbitol dehydrogenase."
So is it endogenous fructose, exogenous fructose or both? In humans we don't know but fructose is in the box...