mercredi 27 mai 2015

Atherosclerosis

http://www.tbiomed.com/content/12/1/9/abstract

Glycocalyx, sulfur and the presence of cholesterol in plaques

http://people.csail.mit.edu/seneff/sulfur_obesity_alzheimers_muscle_wasting.html

Homocystein and carotid atheroma
http://stroke.ahajournals.org/content/33/9/2177.full.pdf+html

mardi 26 mai 2015

Yes this entity does exist and is very difficult to manage.

Why NSAID and/or corticoids should be banned from athletes

http://m.jap.physiology.org/content/118/8/1067.full

Why it is mandatory to check every thing about a "scientific" paper...

rmfmd2@cox.net
This address does not work, nor the others for RM Fleming former cardiologist in Omaha Nebraska USA.
I would have liked to send him some questions about this paper:

Angiology. 2000 Oct;51(10):817-26.

The effect of high-protein diets on coronary blood flow.

Fleming RM1.

Author information

1The Fleming Heart and Health Institute and the Camelot Foundation, Omaha, Nebraska 68114, USA. rfmd1@uswest.net

Abstract

Recent research has demonstrated that successful simultaneous treatment of multiple risk factors including cholesterol, triglycerides, homocysteine, lipoprotein (a) [Lp(a)], fibrinogen, antioxidants, endothelial dysfunction, inflammation, infection, and dietary factors can lead to the regression of coronary artery disease and the recovery of viable myocardium. However, preliminary work revealed that a number of individuals enrolled in the original study went on popular high-protein diets in an effort to lose weight. Despite increasing numbers of individuals following high-protein diets, little or no information is currently available regarding the effect of these diets on coronary artery disease and coronary blood flow. Twenty-six people were studied for 1 year by using myocardial perfusion imaging (MPI), echocardiography (ECHO), and serial blood work to evaluate the extent of changes in regional coronary blood flow, regional wall motion abnormalities, and several independent variables known to be important in the development and progression of coronary artery disease. Treatment was based on homocysteine, Lp (a), C-reactive protein (C-RP), triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and fibrinogen levels. Each variable was independently treated as previously reported. MPI and ECHO were performed at the beginning and end of the study for each individual. The 16 people (treatment group/TG) studied modified their dietary intake as instructed. Ten additional individuals elected a different dietary regimen consisting of a "high-protein" (high protein group/HPG) diet, which they believed would "improve" their overall health. Patients in the TG demonstrated a reduction in each of the independent variables studied with regression in both the extent and severity of coronary artery disease (CAD) as quantitatively measured by MPI. Recovery of viable myocardium was seen in 43.75% of myocardial segments in these patients, documented with both MPI and ECHO evaluations. Individuals in the HPG showed worsening of their independent variables. Most notably, fibrinogen, Lp (a), and C-RP increased by an average of 14%, 106%, and 61% respectively. Progression of the extent and severity of CAD was documented in each of the vascular territories with an overall cumulative progression of 39.7%. The differences between progression and extension of disease in the HPG and the regression of disease in the TG were statistically (p<0 .001="" a="" able="" addition="" and="" artery="" as="" both="" but="" cad.="" cai="" coagulation="" coronary="" deposition="" diet="" dietary="" diets="" disease="" each="" extent="" factors="" following="" for="" function="" guidelines.="" high-protein="" however="" improve="" in="" increases="" independent="" individuals="" inflammatory="" lipid="" may="" medical="" motion="" myocardial="" of="" pathways.="" patients="" precipitate="" prescribed="" progression="" receiving="" recommended="" regress="" results="" risk="" same="" severity="" showed="" significant.="" span="" suggest="" that="" the="" their="" these="" through="" to="" treatment="" variables="" wall="" well="" were="" while="" worsening="" would="">

Especially about the type of protein and the type of fats in the study. I was surprised by the Lp(a) burst as we know tha Lp(a) is genetically regulated and could increase only with a high carb diet...
I was surprised twice to discover the fraud...
http://journalstar.com/news/state-and-regional/nebraska/former-omaha-doctor-faces-possible-sanctions-for-fraud/article_04877e84-3dda-11df-a936-001cc4c03286.html

http://abcnews.go.com/2020/story?id=124294

Should Sage publishing investigate the data of this paper and finally retract it?

Goat's vs cow's milk

http://m.bjsm.bmj.com/content/48/11/871.abstract?sid=d7adf151-dc16-4a66-a2dd-5271f45b0b9e

Goat 89% less alpha1 casein

10% less lactose

Lauersen in Brit J of Sport Medicine 2014: stretching and other means of prevention of sport injuries

http://m.bjsm.bmj.com/content/48/11/871.abstract?sid=d7adf151-dc16-4a66-a2dd-5271f45b0b9e

http://m.bjsm.bmj.com/content/48/11/871.abstract?sid=f7155212-746e-4fa5-9fc4-cf53cd5f936f

Sat fats versus linoleic veg fat: a reappraisal

http://www.bmj.com/content/346/bmj.e8707

Keto Diet in obese

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/

Twin studies and diseases

http://medicalxpress.com/news/2015-05-nature-nurture-results-twins-meta-study.html

DOMS and berries

Cherry Juice Targets Antioxidant Potential and Pain Relief

Kuehl K.S.

Division of Health Promotion and Sports Medicine, Department of Medicine, Oregon Health and Science University, Portland, Oreg., USA

Abstract

Strenuous physical activity increases the risk of musculoskeletal injury and can induce muscle damage resulting in acute inflammation and decreased performance. The human body’s natural response to injury results in inflammation-induced pain, swelling, and erythema. Among sports medicine physicians and athletic trainers, the mainstays of urgent treatment of soft tissue injury are rest, ice, compression, and elevation (RICE). In order to reduce pain and inflammation, anti-inflammatory agents such as non-steroidal anti-inflammatory drugs (NSAIDs) act on the multiple inflammatory pathways, which, although often very effective, can have undesirable side effects such as gastric ulceration and, infrequently, myocardial infarction and stroke. For centuries, natural anti-inflammatory compounds have been used to mediate the inflammatory process and often with fewer side effects. Tart cherries appear to possess similar effectiveness in treating the inflammatory reaction seen in both acute and chronic pain syndromes encountered among athletes and non-athletes with chronic inflammatory disease. This article reviews the antioxidant and anti-inflammatory effects of tart cherries on prevention, treatment, and recovery of soft tissue injury and pain.

Author Contacts

Dr. Kerry S. Kuehl, MD DrPH, Division of Health Promotion and Sports Medicine, Department of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 (USA), Tel. +1 503 494 5991, E-Mail kuehlk@ohsu.edu

lundi 25 mai 2015

Do you have Zinc deficiency?

Vhttp://www.tandfonline.com/doi/abs/10.1080/10408398.2012.742863?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

The answer

http://www.healthaliciousness.com/articles/zinc.php

http://link.springer.com/article/10.1007%2Fs12011-015-0334-3

http://www.ncbi.nlm.nih.gov/m/pubmed/17374687/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548733/

http://m.jap.physiology.org/content/118/8/1067.full

http://www.efsa.europa.eu/fr/efsajournal/doc/3844.pdf

http://www.ncbi.nlm.nih.gov/m/pubmed/25462582/

Obesity related to change of human conditions of life

Never forget that extended life expectancy came with a big side effect: industrially produced, endless available sugars

Glioblastoma and Caloric Restriction low carb diet

http://surgicalneurologyint.com/surgicalint_articles/the-role-of-metabolic-therapy-in-treating-glioblastoma-multiforme/

We need survival data to recommend such diet. It is of great importance to keep in mind that apart low carb high fat diet patients should be in caloric restriction. This si not easy to manage concomitantly with the conventional treatments.

Denise Minger sums it but you should read the paper at the bottom of the post

http://www.thepaleomom.com/wp-content/uploads/2015/05/Ketogenic-Diet-Literature-Review.pdf

http://www.nutritionandmetabolism.com/content/11/1/23

This paper and others emphasizes the predominant role of Caloric Restriction.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100652
We cannot recommend LCHF diets on the basis of clinical studies in D2, MS or normal subjects.
It seems more evidence based to recommend CR and med diet with low carb in adults regardless of what they want to improve.

What is the best trade off for your blood lipid profile?

Small dense LDL are more atherogenic when everything is equal. We don't know if they atherogenic per se or in a multifactorial polygenic model of atheroma.

LDL are particles with hydrophilic molecules outside and lipids (TG, cholesterol esters and other esters) inside. They are produced by the liver. Different parameters are genetic.

The shift from small dense LDL toward large buoyant ones depends mostly of the amount of carbs.

The lowering of LDL at large is more depending on the excess of calories and the excess of carbs and sat lipids.

So what could be the good trade off?

There are very few data to compare clinical advantages of lowering LDL at large and shifting LDL profile...

Rationally one can try the two ways

- avoid excess of calories

- reduce carbs

And check the blood profile with measured LDL and apoB100.

Paleo un article très superficiel

http://m.lavoixdunord.fr/france-monde/regime-paleo-je-mange-comme-un-homme-prehistorique-ia0b0n2835080

Quelques preuves

http://www.nrjournal.com/article/S0271-5317(15)00097-4/abstract

Recent research suggests that traditional grain-based heart-healthy diet recommendations, which replace dietary saturated fat with carbohydrate and reduce total fat intake, may result in unfavorable plasma lipid ratios, with reduced high-density lipoprotein (HDL) and an elevation of low-density lipoprotein (LDL) and triacylglycerols (TG). The current study tested the hypothesis that a grain-free Paleolithic diet would induce weight loss and improve plasma total cholesterol, HDL, LDL, and TG concentrations in nondiabetic adults with hyperlipidemia to a greater extent than a grain-based heart-healthy diet, based on the recommendations of the American Heart Association. Twenty volunteers (10 male and 10 female) aged 40 to 62 years were selected based on diagnosis of hypercholesterolemia. Volunteers were not taking any cholesterol-lowering medications and adhered to a traditional heart-healthy diet for 4 months, followed by a Paleolithic diet for 4 months. Regression analysis was used to determine whether change in body weight contributed to observed changes in plasma lipid concentrations. Differences in dietary intakes and plasma lipid measures were assessed using repeated-measures analysis of variance. Four months of Paleolithic nutrition significantly lowered (P < .001) mean total cholesterol, LDL, and TG and increased (P < .001) HDL, independent of changes in body weight, relative to both baseline and the traditional heart-healthy diet. Paleolithic nutrition offers promising potential for nutritional management of hyperlipidemia in adults whose lipid profiles have not improved after following more traditional heart-healthy dietary recommendations.

Cholesterol you eat is not cholesterol you have on your blood lipid particles

http://www.theverge.com/2015/2/11/8018253/us-dietary-guidelines-drop-cholesterol-warning

dimanche 24 mai 2015

Centenarians and villages

http://www.wsj.com/articles/want-great-longevity-and-health-it-takes-a-village-1432304395?mod=e2tw

Leptin and celastrol

http://www.cell.com/abstract/S0092-8674(15)00559-0

Gluten and the brain

http://www.jnutbio.com/article/S0955-2863(14)00114-4/fulltext

samedi 23 mai 2015

Vit D

http://www.ncbi.nlm.nih.gov/m/pubmed/20592792/

jeudi 21 mai 2015

Autoimmunity and NaCl

http://www.nature.com/nature/journal/v496/n7446/full/nature11868.html

Childhood obesity and processed food consumption

http://www.oecd.org/els/health-systems/Obesity-Update-2014.pdf

Last year, the country enacted taxes on sugary beverages and high-calorie packaged snacks, while limiting junk-food advertisements aimed at children. Mexico ranks near the top among Organization for Economic Cooperation and Development countries for overweight populations and Type 2 diabetes. One-third of Mexican children are already considered overweight, according to government statistics.

http://www.wsj.com/articles/mexico-cracks-down-on-junk-food-in-schools-1431595804

http://www.wsj.com/news/articles/SB10001424127887323864604579065400807494372

It is the controversy of the millenium: statins, LDL cholesterol, saturated fats, animal fat and atheroma

http://www.medicine.ox.ac.uk/bandolier/booth/cardiac/statout.html

http://blog.drbrownstein.com/the-great-statin-debate-a-cardiologist-debates-my-statin-views/

Debate about sat fats

http://www.telegraph.co.uk/journalists/sarah-knapton/10703970/No-link-found-between-saturated-fat-and-heart-disease.html

mercredi 20 mai 2015

Obesity and atheroma

https://secure.quantiamd.com/player/ygkgzpzyc?m=r2_20150506_qpoints&r=y

Paleo diet and seafood

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350785/

http://www.science.mcmaster.ca/geo/people/faculty/schwarcz/index.html

http://onlinelibrary.wiley.com/doi/10.1002/ajpa.22595/abstract

http://abcnews.go.com/Health/scientists-reveal-real-paleo-diet-ancient-skeleton/story?id=30064128

http://www.theguardian.com/us-news/2015/may/18/oregon-lifestyle-wild-native-american-ancestors#img-5

https://m.box.com/shared_item/https%3A%2F%2Fapp.box.com%2Fs%2F7zrxtxstzc6tdeizjosmgcxrd4t07epb

mardi 19 mai 2015

Cholesterol

http://www.karger.com/Article/Abstract/381654

lundi 18 mai 2015

Some news about the American dietitians association

https://www.eatrightpro.org/resource/advocacy/take-action/regulatory-comments/dgac-scientific-report

vendredi 15 mai 2015

Testing your grip is worth than reading food labels

Low grip strength is correlated with higher risk of cvd and cancer

According to the last PURE study in Lancet

Diet and weight

http://www.zoeharcombe.com/2015/05/high-protein-diets-weight-death/

http://www.washingtonpost.com/blogs/wonkblog/wp/2015/05/04/why-diets-dont-actually-work-according-to-a-researcher-who-has-studied-them-for-decades/?postshare=5121431148135491

jeudi 14 mai 2015

Grassfed cattle is environmently friendly

https://epicbar.com/blog/?p=4561

http://www.nature.com/ncomms/2015/150430/ncomms7995/full/ncomms7995.html

http://phys.org/news/2015-05-farmland-boost-carbon-sequestration.html

http://faculty.washington.edu/elizaw/SOC.pdf

One of the favored arguments of vegans about meat is not about your health but about the "future of the planet". Despite the fact that most of our predictions as humans revealed wrong about demography, economics, climate or science, they believed that meat production is a very important environmental issue which justifies avoiding meat and cattle production.
This paper explains clearly that they are wrong if cattle are grassfed.

Nat Commun. 2015 Apr 30;6:6995. doi: 10.1038/ncomms7995.

Emerging land use practices rapidly increase soil organic matter.

Machmuller MB1, Kramer MG2, Cyle TK3, Hill N3, Hancock D3, Thompson A4.

Author information

Abstract

The loss of organic matter from agricultural lands constrains our ability to sustainably feed a growing population and mitigate the impacts of climate change. Addressing these challenges requires land use activities that accumulate soil carbon (C) while contributing to food production. In a region of extensive soil degradation in the southeastern United States, we evaluated soil C accumulation for 3 years across a 7-year chronosequence of three farms converted to management-intensive grazing. Here we show that these farms accumulated C at 8.0 Mg ha(-1) yr(-1), increasing cation exchange and water holding capacity by 95% and 34%, respectively. Thus, within a decade of management-intensive grazing practices soil C levels returned to those of native forest soils, and likely decreased fertilizer and irrigation demands. Emerging land uses, such as management-intensive grazing, may offer a rare win-win strategy combining profitable food production with rapid improvement of soil quality and short-term climate mitigation through soil C-accumulation.

In the paper Figure 2 shows nicely how rapidly Carbon accumulated in soils with a return to the content of native forest soils in a decade!

The worst is never certain but ideologized people use it to their aims.

https://chriskresser.com/impacts-and-ethics-of-eating-meat-with-diana-rodgers/

Bee controversy

http://www.forbes.com/sites/henrymiller/2015/05/13/the-new-bee-crisis-is-just-like-the-old-crisis-only-different/

Wait and see: experimental studies and real life

http://ajcn.nutrition.org/content/early/2012/11/27/ajcn.112.047142.full.pdf+html

mercredi 13 mai 2015

Metformin: use it in cancer patients with diabetes!

http://www.biomedcentral.com/1741-7007/12/85

http://www.metabolism-diet-and-disease.com/

mardi 12 mai 2015

The corn oil trial by Rose is packed with surprises!

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2166702/?page=2

You need vitamin D and you can produce it

http://www.ncbi.nlm.nih.gov/m/pubmed/25703782/

Iron

http://blogs.nejm.org/now/index.php/iron-deficiency-anemia/2015/05/08/

Changes in diet management of D2 patients

http://www.dietdoctor.com/the-perfect-treatment-for-diabetes-and-weight-loss

GMO and agrobacterium

http://www.npr.org/blogs/goatsandsoda/2015/05/05/404198552/natural-gmo-sweet-potato-genetically-modified-8-000-years-ago?utm_campaign=storyshare&utm_source=facebook.com&utm_medium=social

More on med diet

http://www.wsj.com/articles/mediterranean-diet-boosts-brain-power-study-finds-1431356748

http://archinte.jamanetwork.com/Mobile/article.aspx?articleid=2293082

Centenarians longevity and IGF1

http://www.hormones.gr/204/article/article.html

http://www.ncbi.nlm.nih.gov/m/pubmed/21459318/

lundi 11 mai 2015

Egos and diseases

http://suppversity.blogspot.de/2012/02/eat-whole-eggs-all-day-and-throw-your.html?m=1

You need protein and W3 LCPUFA for endurance

http://www.nrcresearchpress.com/doi/abs/10.1139/apnm-2013-0591#.VVCFj2CZa-J

http://www.tandfonline.com/doi/abs/10.1080/17461391.2014.949310#.VVB7447tlBc

Low indoors temp in winter, cold shower and getting off pajamas mean less diabetes

http://www.ncbi.nlm.nih.gov/m/pubmed/24954193/

dimanche 10 mai 2015

Vegans and vit B12

http://www.mdpi.com/2072-6643/6/8/3259

http://www.ncbi.nlm.nih.gov/m/pubmed/23356638/

lundi 4 mai 2015

Genomics and CVD

http://www.biomedcentral.com/1471-2156/15/12

Sex gap for insulin resistance partially explained

"At similar BMI levels, women maintain their insulin sensitivity when compared to men despite having higher adiposity⁹. In this study, we investigated the sex differences in muscle PTEN gene expression, protein content and activity to see if PTEN downregulation is involved in this paradox.

We demonstrate that women have lower muscle PTEN gene expression when compared to men, despite having higher adipose tissue mass. This is coupled with increased inactivation of PTEN protein.

PTEN is a dual protein and lipid phosphatase that interferes with the insulin-signaling pathway via its lipid phosphatase activity. PTEN itself can be inactivated by phosphorylation^14, 15, 16, and this post-translational modification impact PTEN activity. PTEN can autoinhibit itself through S380-385 sites, whereby phosphorylation of S385 leads to the phosphorylation of S380 and Threonine sites, and binding of the COOH tail to the C2 and phosphatase domains, preventing the binding of PTEN to a complex of protein that drive its activity¹⁷."

http://www.nature.com/srep/2015/150317/srep09154/full/srep09154.html