Is your physician able to explain a healthy diet?

What is your physician diet?






Very disturbing, US physicians are not on the healthy tracks.

Measure them it's free and more predictive than BMI

Waist circumference and waist/hip ratio are better predictive risk factors for mortality and morbidity after colorectal surgery than body mass index and body surface area.

Ann Surg.  2013; 258(5):722-30 (ISSN: 1528-1140)

Kartheuser AH; Leonard DF; Penninckx F; Paterson HM; Brandt D; Remue C; Bugli C; Dozois E; Mortensen N; Ris F; Tiret E;  

OBJECTIVES: To determine whether body fat distribution, measured by waist circumference (WC) and waist/hip ratio (WHR), is a better predictor of mortality and morbidity after colorectal surgery than body mass index (BMI) or body surface area (BSA).

BACKGROUND: Obesity measured by BMI is not a consistent risk factor for postoperative mortality and morbidity after abdominal surgery. Studies in metabolic and cardiovascular diseases have shown WC and WHR to be better outcome predictors than BMI.

METHODS: A prospective multicenter international study was conducted among patients undergoing elective colorectal surgery. The WHR, BMI, and BSA were derived from body weight, height, and waist and hip circumferences measured preoperatively. Uni- and multivariate analyses were performed to identify risk factors for postoperative outcomes.

RESULTS: A total of 1349 patients (754 men) from 38 centers in 11 countries were included. Increasing WHR significantly increased the risk of conversion [odds ratio (OR) = 15.7, relative risk (RR) = 4.1], intraoperative complications (OR = 11.0, RR = 3.2), postoperative surgical complications (OR = 7.7, RR = 2.0), medical complications (OR = 13.2, RR = 2.5), anastomotic leak (OR = 13.7, RR = 3.3), reoperations (OR = 13.3, RR = 2.9), and death (OR = 653.1, RR = 21.8). Both BMI (OR = 39.5, RR = 1.1) and BSA (OR = 4.9, RR = 3.1) were associated with an increased risk of abdominal wound complication. In multivariate analysis, the WHR predicted intraoperative complications, conversion, medical complications, and reinterventions, whereas BMI was a risk factor only for abdominal wall complications; BSA did not reach significance for any outcome.

CONCLUSIONS: The WHR is predictive of adverse events after elective colorectal surgery. It should be used in routine clinical practice and in future risk-estimating systems.

Eat plenty of animal protein but avoid antibiotics

http://www.nytimes.com/2014/01/28/science/antibiotics-in-animals-tied-to-risk-of-human-infection.html?nl=health&emc=edit_hh_20140128&_r=0

Safe starches: igname

Biocides and the risks of unknown low level chronic exposure

http://archneur.jamanetwork.com/article.aspx?articleid=1816015

http://archneur.jamanetwork.com/article.aspx?articleid=1816013

http://www.medpagetoday.com/Neurology/AlzheimersDisease/44001?

Hunter gatherers in Europe

NATURE | LETTER

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Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European

• Iñigo Olalde,
• Morten E. Allentoft,
• Federico Sánchez-Quinto,
• Gabriel Santpere,
• Charleston W. K. Chiang,
• Michael DeGiorgio,
• Javier Prado-Martinez,
• Juan Antonio Rodríguez,
• Simon Rasmussen,
• Javier Quilez,
• Oscar Ramírez,
• Urko M. Marigorta,
• Marcos Fernández-Callejo,
• María Encina Prada,
• Julio Manuel Vidal Encinas,
• Rasmus Nielsen,
• Mihai G. Netea,
• John Novembre,
• Richard A. Sturm,
• Pardis Sabeti,
• Tomàs Marquès-Bonet,
• Arcadi Navarro,
• Eske Willerslev
• & Carles Lalueza-Fox

• Affiliations
• Contributions
• Corresponding authors

Nature

 

(2014)

 

doi:10.1038/nature12960

Received

 

22 October 2013 

Accepted

 

17 December 2013 

Published online

 

26 January 2014

Article tools

Ancient genomic sequences have started to reveal the origin and the demographic impact of farmers from the Neolithic period spreading into Europe^1, 2, 3. The adoption of farming, stock breeding and sedentary societies during the Neolithic may have resulted in adaptive changes in genes associated with immunity and diet⁴. However, the limited data available from earlier hunter-gatherers preclude an understanding of the selective processes associated with this crucial transition to agriculture in recent human evolution. Here we sequence an approximately 7,000-year-old Mesolithic skeleton discovered at the La Braña-Arintero site in León, Spain, to retrieve a complete pre-agricultural European human genome. Analysis of this genome in the context of other ancient samples suggests the existence of a common ancient genomic signature across western and central Eurasia from the Upper Paleolithic to the Mesolithic. The La Braña individual carries ancestral alleles in several skin pigmentation genes, suggesting that the light skin of modern Europeans was not yet ubiquitous in Mesolithic times. Moreover, we provide evidence that a significant number of derived, putatively adaptive variants associated with pathogen resistance in modern Europeans were already present in this hunter-gatherer.

They lived there

EPA AND DHA are anti-inflammatory PUFA

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A₄hydrolase (LTA₄H), and shifts macrophage phenotype

1. Jesmond Dalli*, 
2. Min Zhu^†‡, 
3. Nikita A. Vlasenko^†‡, 
4. Bin Deng*,
5. Jesper Z. Haeggström^§, 
6. Nicos A. Petasis^†‡,¹ and 
7. Charles N. Serhan*,¹

+Author Affiliations

1. ^*Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA;
2. ^†Department of Chemistry and
3. ^‡Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, California, USA; and
4. ^§Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

1. ↵1Correspondence: C.N.S., Harvard Institutes of Medicine, 77 Ave. Louis Pasteur, HIM 829, Boston, MA 02115, USA. E-mail: cnserhan@zeus.bwh.harvard.edu; N.A.P., University of Southern California, 837 Bloom Walk, LHI 219, Los Angeles, CA 90089, USA. E-mail: petasis@usc.edu

Abstract

Maresins are produced by macrophages from docosahexaenoic acid (DHA) and exert potent proresolving and tissue homeostatic actions. Maresin 1 (MaR1; 7R,14S-dihydroxy-docosa-4Z,8E,10E,12Z,16Z,19Z-hexaenoic acid) is the first identified maresin. Here, we investigate formation, stereochemistry, and precursor role of 13,14-epoxy-docosahexaenoic acid, an intermediate in MaR1 biosynthesis. The 14-lipoxygenation of DHA by human macrophage 12-lipoxygenase (hm12-LOX) gave 14-hydro(peroxy)-docosahexaenoic acid (14-HpDHA), as well as several dihydroxy-docosahexaenoic acids, implicating an epoxide intermediate formation by this enzyme. Using a stereo-controlled synthesis, enantiomerically pure 13S,14S-epoxy-docosa-4Z,7Z,9E,11E,16Z,19Z-hexaenoic acid (13S,14S-epoxy-DHA) was prepared, and its stereochemistry was confirmed by NMR spectroscopy. When this 13S,14S-epoxide was incubated with human macrophages, it was converted to MaR1. The synthetic 13S,14S-epoxide inhibited leukotriene B₄ (LTB₄) formation by human leukotriene A₄ hydrolase (LTA₄H) ∼40% (P<0 .05="" a="" as="" extent="" lta="" similar="" style="border: 0px; font-family: inherit; font-size: 0.85em; font-style: inherit; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit;" sub="" to="">4

 (∼50%, P<0 .05="" 13="" but="" by="" converted="" em="" enzyme.="" mar1="" not="" style="border: 0px; font-family: inherit; font-size: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: baseline;" this="" to="" was="">S,14S-epoxy-DHA also reduced (∼60%;P<0 .05="" 13="" acid="" and="" arachidonic="" biosynthesis="" by="" conversion="" em="" epoxide="" establish="" findings="" from="" hm12-lox="" m1.="" m1="" m2="" macrophages="" mar1="" more="" of="" phenotype="" produced="" promoted="" style="border: 0px; font-family: inherit; font-size: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: baseline;" than="" the="" these="" to="" together="" which="">S,14S-epoxide, its absolute stereochemistry, its precursor role in MaR1 biosynthesis, and its own intrinsic bioactivity. Given its actions and role in MaR1 biosynthesis, this epoxide is now termed 13,14-epoxy-maresin (13,14-eMaR) and exhibits new mechanisms in resolution of inflammation in its ability to inhibit proinflammatory mediator production by LTA₄ hydrolase and to block arachidonate conversion by human 12-LOX rather than merely terminating phagocyte involvement.—Dalli, J., Zhu, M., Vlasenko, N. A., Deng, B., Haeggström, J. Z., Petasis, N. A., Serhan, C. N. The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A₄ hydrolase (LTA₄H) and shifts macrophage phenotype.

Your parents don't only give you their genes but their habits...

Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring

1. Sheau-Fang Ng*,§, 
2. Ruby C. Y. Lin†, 
3. Christopher A. Maloney*,
4. Neil A. Youngson*, 
5. Julie A. Owens∥ and 
6. Margaret J. Morris*,¹

1. ^*Department of Pharmacology, School of Medical Sciences, ^†Ramaciotti Centre for Genomics, and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia;
2. ^§Department of Paediatrics, Faculty of Medicine, National University of Malaysia, Cheras, Kuala Lumpur, Malaysia; and
3. ^∥School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia

1. Correspondence: Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia, 2052. E-mail:m.morris@unsw.edu.au

Abstract

We previously showed that paternal high-fat diet (HFD) consumption programs β-cell dysfunction in female rat offspring, together with transcriptome alterations in islets. Here we investigated the retroperitoneal white adipose tissue (RpWAT) transcriptome using gene and pathway enrichment and pathway analysis to determine whether commonly affected network topologies exist between these two metabolically related tissues. In RpWAT, 5108 genes were differentially expressed due to a paternal HFD; the top 5 significantly enriched networks identified by pathway analysis in offspring of HFD fathers compared with those of fathers fed control diet were: mitochondrial and cellular response to stress, telomerase signaling, cell death and survival, cell cycle, cellular growth and proliferation, and cancer. A total of 187 adipose olfactory receptor genes were down-regulated. Interrogation against the islet transcriptome identified specific gene networks and pathways, including olfactory receptor genes that were similarly affected in both tissues (411 common genes, P<0 .05="" a="" and="" cancer="" cell="" common="" cycle="" em="" gene="" highlight="" hub="" in="" molecular="" nbsp="" network="" particular="" same="" style="border: 0px; font-family: inherit; font-size: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: baseline;" the="" we="" with="">Myc

, suggesting early onset developmental changes that persist, shared responses to programmed systemic factors, or crosstalk between tissues. Thus, paternal HFD consumption triggers unique gene signatures, consistent with premature aging and chronic degenerative disorders, in both RpWAT and pancreatic islets of daughters.—Ng, S.-F., Lin, R. C., Maloney, C. A., Youngson, N. A., Owens, J. A., Morris, M. J. Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring.

Mangez du gras! Eat fats

Avocats	Noix de Coco et graisse de coco	Olives noires mures ou très peu salées	Amandes, noix de Grenoble, noisettes, nois du Brésil, noix de Macadamia
Beurre cru	Moelle des os longs	Veau, boeuf et agneau à l'herbe	Tous les poissons gras sauvages

Toutes ces bonnes graisses doivent être mangées crues ou cuites à moins de 70°...
You can cook but don't heat above 70° Celsius

Pour cela il vous faut un four à basse temperature

A low temp oven is mandatory!

Keep your protein status in the upper quartile!

http://www.medpagetoday.com/MeetingCoverage/SCCM/43801

Some arguments about paleodiet

http://paleo-diet-menu.blogspot.fr/2013/03/the-paleo-diet-foods-health-benefits.html

Increase your own vitamin D production

http://www.sperti.com/The-Vitamin-D-Lamp-model-D-UV-F-p/d-uv-f.htm

New effects of DHA on de novo lipid synthesis

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0083756

More on low carb diets

http://www.youtube.com/watch?v=GC1vMBRFiwE

Low carb in human clinical trials

http://authoritynutrition.com/23-studies-on-low-carb-and-low-fat-diets/

Low carb clinical trial from Harvard

http://www.hsph.harvard.edu/review/review_fall_04/rvw_diet.html

Testing 1-2-3-4 What mix of carbohydrate, fat, and protein should people eat in order to lose weight, keep it off, and stay healthy? HSPH’s diet study will examine four possibilities.
15% Protein 20% Fat 65% Carbohydrates	25% Protein 20% Fat 55% Carbohydrates	15% Protein 40% Fat 45% Carbohydrates	25% Protein 40% Fat 35% Carbohydrates

You believe that low carb diets are harmful?

http://www.lowcarbdietitian.com/1/post/2013/09/misrepresenting-the-evidence-on-low-carb-diets.html

Pigouvian principle of taxation

ATB use in animals should be taxed as high as the amount of negative externalities.



http://www.treehugger.com/economics/could-higher-fees-reduce-use-antibiotics-farms.html

Bees die also because they are infected

http://www.treehugger.com/natural-sciences/scientists-discover-another-cause-bee-deaths-and-its-really-bad-news.html

It is a correlation but it is amazing

• Article

Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes

WHIMS-MRI Study

1. James V. Pottala, PhD, 
2. Kristine Yaffe, MD, 
3. Jennifer G. Robinson, MD, MPH, 
4. Mark A. Espeland, PhD, 
5. Robert Wallace, MD, MSc and 
6. William S. Harris, PhD

-SHOW AFFILIATIONS

| + SHOW FULL DISCLOSURES

1. From the Department of Internal Medicine (J.V.P., W.S.H.), Sanford School of Medicine, University of South Dakota, Sioux Falls; Health Diagnostic Laboratory Inc. (J.V.P., W.S.H.), Richmond, VA; Department of Psychiatry (K.Y.), University of California Medical Center, San Francisco; Departments of Epidemiology and Internal Medicine (J.R., R.W.), University of Iowa College of Public Health, Iowa City; Department of Biostatistical Services (M.A.E.), Wake Forest School of Medicine, Winston-Salem, NC; and OmegaQuant Analytics (W.S.H.), Sioux Falls, SD.

1. Correspondence to Dr. Pottala: jpottala@hdlabinc.com