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mardi 21 janvier 2014

Vitamin D is doing nothing except for bones? Actually?

http://archneur.jamanetwork.com/article.aspx?articleid=1815002

http://www.medpagetoday.com/Neurology/MultipleSclerosis/43899?

http://iospress.metapress.com/content/t587180765787517/?

http://www.medpagetoday.com/Neurology/GeneralNeurology/43974

Read these comments in Medpage:
http://www.medpagetoday.com/comments.cfm?tbid=43974



Interesting and at last. I take things a bit further with the following recommendations AVOID: Food intolerances; Trans-fatty acids, hydrogentated oils, margarine, vegetable shortenings, imitation butter spreads, most commercial peanut spreads, fried foods, fast foods, Ghee, barbeque meats. SUPPLEMENTS: Essential Fatty Acids; Flax oil (2 tsp q.d.) Max EPA 3 caps b.i.d. Black Currant Oil (2 caps b.i.d.); Vitamin E (800 IU q.i.d.); Selenium (200 mcg q.i.d); Lecithin (2400 mg b.i.d.) Vitamin B12 IM or 1000 mcg b.i.d. Must have Vit D3 Recommend Clinicians 1 drop tds 2-AEP calcium 6-12 capsules per day 2-AEP magnesium 3-6 capsules per day 2-AEP complex 3-6 capsules per day L-Carnitine 500mg twice a day Vitamin B1 200-400mg/day Dionaea Muscipula (Venus Fly Trap extract) 20 drops three times a day K-Mg (Potassium-magnesium aspartate) 500mg, 3 times a day Avoid Zinc: Even in small amounts, it may dramatically enhance the progression of the disease. Alastair.

This article reminded me of Dr. Paolo Zamboni, who took 65 patients with relapsing-remitting MS, and performed a simple operation to unblock restricted bloodflow out of the brain. two years after the surgery, 73% of the patients had no symptoms. Breakthrough? Not so fast as even while many MS patients had the surgery, mainstream medicine wouldn't support it without a test so ones began in Buffalo [I think] and Canada that weren't fruitful. Now vitamin D? Did they even consider those levels in the previous tests or that Italians have a lot of differences in diet and surely a lot of other details. What about all the existing drugs that pharmaceutical manufacturers are testing for other disease states that phase IV post marketing trials indicate are helped, or even worse all the success that physicians have found in using drugs "off label" or in larger than FDA approved doses that just show they save lives? How do patients even find out about these which can save billions in costs? I'm 
While vitamin D may well have an important role in MS progression, has anyone looked at the OTHER nutrients that work with vitamin D in various processes? No? Oh. Since we like to look at nutrients/hormones one-at-a-time, it is not surprising that we remain befuddled. For example, myelin sheath is impaired by lack of enough fat soluble nutrients, including especially vitamin K2, as well as some minerals. K2 is a nutrient/hormone that works in conjunction with vitamin D, so those who have more K2 may have better results with supplemental D than those who have less. Minerals in the diet are similarly variable in people. And vitamin D is involved in the creation of osteocalcin(unlike rodents that we tend to use for studies, who do not need vitamin D to make osteocalcin), which has myriad important implications in many diseases, including potentially, MS. Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides. (2010) Yes, rodents were used here, but note what makes for better myelin. Do humans get enough vitamin K2 (not K1) and do they have all the nutrients that make for proper action of UBIAD1 to make MK-4 in tissues throughout the body? No. Most of us are deficient in some aspects of these processes and Americans (in particular) have very, very little long chain vitamin K2 in their diets. Plus, we block MK- 4 biosynthesis with dear dihydrophylloquinone. So...the question of vitamin D is only a tiny aspect of the larger picture and we need to think bigger and more inclusively..

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