Coffee in a chart

The complexity of caffeine physiology

There is an undispsuted effect of caffeine which is missed in this chart: increased diuresis and sodium loss!

References
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https://www.ncbi.nlm.nih.gov/pubmed/25832334

2. US National Library of Medicine (NIH). Caffeine.
https://medlineplus.gov/caffeine.html

3. Lindsay J et al. (2002). "Risk factors for Alzheimer’s disease: a prospective analysis from the Canadian Study of Health and Aging." Am J Epidemiol. 156(5):445-53.
https://www.ncbi.nlm.nih.gov/pubmed/12196314

4. Palacios et al. (2012). "Caffeine and risk of Parkinson's disease in a large cohort of men and women." Mov Disord. 27(10):1276-82.
https://www.ncbi.nlm.nih.gov/pubmed/22927157

5. van Dam RM. (2008). "Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer." Appl Physiol Nutr Metab. 33(6):1269-83.
https://www.ncbi.nlm.nih.gov/pubmed/19088789

6. Amin N et al. (2012). "Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM." Mol Psychiatry. 17(11):1116-29.
https://www.ncbi.nlm.nih.gov/pubmed/21876539

7. Sachse C et al. (1999). "Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine." Br J Clin Pharmacol. 47(4):445-9.
https://www.ncbi.nlm.nih.gov/pubmed/10233211