Overview of the purported pathophysiological mechanisms explaining the association between sarcopenia and cognitive function.

 

https://academic.oup.com/biomedgerontology/article/77/10/1959/6602136?login=false 

Overview of the purported pathophysiological mechanisms explaining the association between sarcopenia and cognitive function. Yellow marked fields could also be affected by the mediating role of exercise. Aβ = amyloid beta; BBB = blood–brain barrier; BDNF = brain-derived neurotrophic factor; CRP = C-reactive protein; CNS = central nervous system; CDLK-5 = cyclin-dependent-like kinase 5; FNDC5 = fibronectin type III domain containing 5; IDE = insulin-degrading enzyme; IGF-1 = insulin-like growth factor 1; IL-6 = interleukin 6; ROS = reactive oxygen species; SASP = senescence-associated secretory phenotype; UPS = ubiquitin–proteasome system.