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jeudi 4 décembre 2014

Biases in the comprehension of atheroma: experimental studies vs human ones and lipid profile vs delayed mortality

1/  http://www.nature.com/nature/journal/v515/n7527/pdf/515346a.pdf

Mice and human a very important genomics difference

2/ Lipid profile is NOT the main risk factor and is very complex to interpret
- LDL chol is a weak risk factor versus Tobacco or sedentary life style
- LDL chol is like total chol a few years ago, it lacks of specificity because particle size is key
- unconventional lipid risk factors are usually missing in studies especially old studies like: HDL ApoB100, Lpa, TG, insulin
- the role of oxLDL is not clear

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