1/ pour les femmes enceintes:
Article
Circulating 25-Hydroxyvitamin D3 in Pregnancy and Infant Neuropsychological Development
Eva Morales, MD, PhD, MPH
Mònica Guxens, MD, MPH, PhD
Sabrina Llop, MSc, PhD
Clara L. Rodríguez-Bernal, DDS, MPH
Adonina Tardón, MD, PhD
Isolina Riaño, MD, PhD
Jesús Ibarluzea, MSc, PhD
Nerea Lertxundi, MSc
Mercedes Espada, PhD
Agueda Rodriguez, MD
Jordi Sunyer, MD, PhD and
on behalf of the INMA Project
Author Affiliations
aCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain;
bHospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain;
cCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;
dCentro Superior de Investigación en Salud Publica (CSISP), Valencia, Spain;
eDepartment of Public Health, University of Oviedo, Asturias, Spain;
fServicio de Pediatria, Hospital San Agustín, Avilés, Asturias, Spain;
gDepartamento de Sanidad del Gobierno Vasco, Subdirección de Salud Publica de Guipuzcoa, Euskadi, Spain;
hInstituto de Investigación Sanitaria de Euskadi (BIODONOSTIA), Euskadi, Spain;
iFaculty of Psychology, University of Basque Country, Euskadi, Spain;
jClinical Chemistry Unit, Public Health Laboratory of Bilbao, Euskadi, Spain;
kServicio de Ginecología y Obstetricia, Hospital Parc Taulí, Sabadell, Catalonia, Spain; and
lPompeu Fabra University, Barcelona, Catalonia, Spain
* Drs Morales and Guxens contributed equally to this work.
ABSTRACT
OBJECTIVE: To investigate whether circulating 25-hydroxyvitamin D3[25(OH)D3] concentration in pregnancy is associated with neuropsychological development in infants.
METHODS: The Spanish population-based cohort study INfancia y Medio Ambiente Project recruited pregnant women during the first trimester of pregnancy between November 2003 and February 2008. Completed data on 1820 mother-infant pairs were used. Maternal plasma 25(OH)D3 concentration was measured by high-performance liquid chromatography in pregnancy (mean 13.5±2.1 weeks of gestation). Offspring mental and psychomotor scores were assessed by trained psychologists at age 14 months (range, 11–23) by using the Bayley Scales of Infant Development. β-Coefficients with 95% confidence intervals (CIs) of mental and psychomotor scores associated with continuous or categorical concentrations of maternal plasma 25(OH)D3 were calculated by using linear regression analysis.
RESULTS: The median plasma value of 25(OH)D3 in pregnancy was 29.6 ng/mL (interquartile range, 21.8–37.3). A positive linear relationship was found between circulating concentrations of maternal 25(OH)D3concentrations in pregnancy and mental and psychomotor scores in the offspring. After adjustment for potential confounders, infants of mothers with 25(OH)D3 concentrations in pregnancy >30 ng/mL showed higher mental score (β = 2.60; 95% CI 0.63–4.56) and higher psychomotor score (β = 2.32; 95% CI 0.36–4.28) in comparison with those of mothers with 25(OH)D3concentrations <20 br="br" ml.="ml." ng="ng">
CONCLUSIONS: Higher circulating concentration of maternal 25(OH)D3 in pregnancy was associated with improved mental and psychomotor development in infants.
2/ pour tous les autres...
- Atherosclerosis/Lipoproteins
25-Hydroxyvitamin D Levels and Risk of Ischemic Heart Disease, Myocardial Infarction, and Early Death
Population-Based Study and Meta-Analyses of 18 and 17 Studies
- Peter Brøndum-Jacobsen,
- Marianne Benn,
- Gorm B. Jensen,
- Børge G. Nordestgaard
-
From the Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark (P.B.-J., M.B., B.G.N.); Faculty of Health Sciences, University of Copenhagen, Denmark (P.B.-J., M.B., B.G.N.); and the Copenhagen City Heart Study, Bispebjerg Hospital, Copenhagen University Hospital, Denmark (G.B.J., B.G.N.).
- Correspondence to Børge G. Nordestgaard, MD, DMSc, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark. E-mail Boerge.Nordestgaard@regionh.dk
Abstract
Objective—We tested the hypothesis that reduced plasma 25-hydroxyvitamin D associates with increased risk of ischemic heart disease, myocardial infarction, and early death.
Methods and Results—We measured baseline plasma 25-hydroxyvitamin D in 10 170 women and men from the Danish general population without vitamin D–fortified food. During 29 years of follow-up, 3100 persons developed ischemic heart disease, 1625 myocardial infarction, and 6747 died. Decreasing plasma 25-hydroxyvitamin D levels were associated with increasing risk of ischemic heart disease, myocardial infarction, and early death as a function of seasonally adjusted percentile categories (P for trend, 2×10−5–3×10–53). Comparing individuals with plasma 25-hydroxyvitamin D levels at the 1st to 4th percentile with individuals with levels at the 50th to 100th percentile, the multivariable adjusted risk was increased by 40% (95% CI, 14%–72%) for ischemic heart disease, by 64% (25%–114%) for myocardial infarction, by 57% (38%–78%) for early death, and by 81% (40%–135%) for fatal ischemic heart disease/myocardial infarction. In the meta-analyses of 18 and 17 studies, risk of ischemic heart disease and early death were increased by 39% (25%–54%) and 46% (31%–64%) for lowest versus highest quartile of 25-hydroxyvitamin D level.
Conclusion—We observed increasing risk of ischemic heart disease, myocardial infarction, and early death with decreasing plasma 25-hydroxyvitamin D levels. These findings were substantiated in meta-analyses.
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