1/ pour les femmes enceintes:
Circulating 25-Hydroxyvitamin D3 in Pregnancy and Infant Neuropsychological Development
Eva Morales, MD, PhD, MPH
Mònica Guxens, MD, MPH, PhD
Sabrina Llop, MSc, PhD
Clara L. Rodríguez-Bernal, DDS, MPH
Adonina Tardón, MD, PhD
Isolina Riaño, MD, PhD
Jesús Ibarluzea, MSc, PhD
Nerea Lertxundi, MSc
Mercedes Espada, PhD
Agueda Rodriguez, MD
Jordi Sunyer, MD, PhD and
on behalf of the INMA Project
aCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain;
bHospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain;
cCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;
dCentro Superior de Investigación en Salud Publica (CSISP), Valencia, Spain;
eDepartment of Public Health, University of Oviedo, Asturias, Spain;
fServicio de Pediatria, Hospital San Agustín, Avilés, Asturias, Spain;
gDepartamento de Sanidad del Gobierno Vasco, Subdirección de Salud Publica de Guipuzcoa, Euskadi, Spain;
hInstituto de Investigación Sanitaria de Euskadi (BIODONOSTIA), Euskadi, Spain;
iFaculty of Psychology, University of Basque Country, Euskadi, Spain;
jClinical Chemistry Unit, Public Health Laboratory of Bilbao, Euskadi, Spain;
kServicio de Ginecología y Obstetricia, Hospital Parc Taulí, Sabadell, Catalonia, Spain; and
lPompeu Fabra University, Barcelona, Catalonia, Spain
* Drs Morales and Guxens contributed equally to this work.
OBJECTIVE: To investigate whether circulating 25-hydroxyvitamin D3[25(OH)D3] concentration in pregnancy is associated with neuropsychological development in infants.
METHODS: The Spanish population-based cohort study INfancia y Medio Ambiente Project recruited pregnant women during the first trimester of pregnancy between November 2003 and February 2008. Completed data on 1820 mother-infant pairs were used. Maternal plasma 25(OH)D3 concentration was measured by high-performance liquid chromatography in pregnancy (mean 13.5±2.1 weeks of gestation). Offspring mental and psychomotor scores were assessed by trained psychologists at age 14 months (range, 11–23) by using the Bayley Scales of Infant Development. β-Coefficients with 95% confidence intervals (CIs) of mental and psychomotor scores associated with continuous or categorical concentrations of maternal plasma 25(OH)D3 were calculated by using linear regression analysis.
RESULTS: The median plasma value of 25(OH)D3 in pregnancy was 29.6 ng/mL (interquartile range, 21.8–37.3). A positive linear relationship was found between circulating concentrations of maternal 25(OH)D3concentrations in pregnancy and mental and psychomotor scores in the offspring. After adjustment for potential confounders, infants of mothers with 25(OH)D3 concentrations in pregnancy >30 ng/mL showed higher mental score (β = 2.60; 95% CI 0.63–4.56) and higher psychomotor score (β = 2.32; 95% CI 0.36–4.28) in comparison with those of mothers with 25(OH)D3concentrations <20 br="br" ml.="ml." ng="ng">
CONCLUSIONS: Higher circulating concentration of maternal 25(OH)D3 in pregnancy was associated with improved mental and psychomotor development in infants.