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vendredi 23 octobre 2015

High fat diet in mice and glucose tolerance: not a reliable model for humans

http://www.foodnavigator.com/Science/High-fat-diet-could-cause-brain-changes-that-lead-to-anxiety-and-depression-Mouse-data/?utm_source=Newsletter_SponsoredSpecial&utm_medium=email&utm_campaign=Newsletter%2BSponsoredSpecial&c=dC5HnbRQjqkJpHo0PfuwKRaIKICT6IEC?cxtnav=1445594596294?cxtnav=1445596440439
This title recalled me how reporting science is difficult...
1/ figures 3,4 and 5 of the paper are not available...
2/ reference: http://onlinelibrary.wiley.com/doi/10.1111/bph.13343/abstract
3/ The HFD in mice is a model to study GLUCOSE intolerance!
http://diabetes.diabetesjournals.org/content/53/suppl_3/S215.full

4/it is not a matter of specific fatty acids except for W3 PUFA which are not associated with glucose intolerance:
"Also, in our own study, we were not able to detect significant correlations between the saturation level of free fatty acids and insulin action as estimated from whole-body glucose disposal after an insulin challenge (Figure 2)."
http://onlinelibrary.wiley.com/doi/10.1038/oby.2007.608/full

As usual those exp studies on rodents should be reported with extreme caution about any translational knowledge applicable to humans. issues about carbs and fats are complex and extremely controversial so a more balanced approach should be to report also other studies by instance this one:

"Results: Higher TC, higher HDL-C, and lower triglycerides were associated with higher age 70 cognitive scores in most cognitive domains. These relationships were no longer significant after covarying for childhood IQ, with the exception a markedly attenuated association between TC and processing speed, and triglycerides and age 70 IQ. In the fully adjusted model, all conventionally significant (p < 0.05) effects were removed. Childhood IQ predicted statin use in old age. Statin users had lower g, processing speed, and verbal ability scores at age 70 years after covarying for childhood IQ, but significance was lost after adjusting for TC levels.
Conclusions: These results suggest that serum cholesterol and cognitive function are associated in older age via the lifelong stable trait of intelligence. Potential mechanisms, including lifestyle factors, are discussed." 
http://dysnutrition.blogspot.fr/2015/10/cholesterol-and-cognitive-function.html

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