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lundi 26 octobre 2015

Low carb diets are doing better on weight loss and CVD risk factors.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139817
Still a great difference between races:
Fig 3.  Bayesian probabilities for mean differences in (a) weight loss and (b) estimated 10-year ASCVD risk scores.
This is not negligible and side effects are few.

Stone after stone the destruction of the low fat myth which fueled so many mistakes and so much benefit for agro-industry.
The results of this study on conventional biomarkers of CVD are amazing.
Another time looking at those results marker by marker is totally irrational. The risk is far better appreciated by the combination of factors.
Example: LDL
Low fat works better on LDL BUT we don't know if the LDL particles are the same on low fat diets and low carb diets... And several studies showed that LDL particles profile is more atherogenic on high carb diet and very atherogenic if the carbs do have a high GI.
In the same comparison low fat diets DO NOT improve substantially HDL contrary to low carb diets and we know that the ratio between HDL/LDL particles is a potent risk factor. In the same perspective of global lipid evaluation low carb drastically decrease TG. TG is an independent risk factor of atheroma through chylomicron remnants and VLDL especially in the postprandial period. 
My point is that low carb diets moderately decrease all cholesterol containing particles and improve the number and/or size of the HDL particles so the non HDL cholesterol particles decrease. These non HDL cholesterol particles are the major biomarker of atheroma in the lipid heart hypothesis. In summary low carb diets impact all the biomarkers of atheroma instead of low fat diets which are only decreasing LDL cholesterol. Another time total cholesterol is in only some studies poorly correlated with CVD and should not have been mentioned in this comparison.
But lipids are not by far the only biomarkers of atheroma.
Low carb diets which are very efficient on weight (-12 vs -6,5 %) decrease systolic blood pressure which is the major factor of extracranial atheroma in the supra-aortic trunks where originate 25% of TIA and Stroke.
What about acceptance of those diets?
"The magnitude of carbohydrate and fat restrictions were calculated from the time of lowest daily intake (Table 2), at which time the average carbohydrate intake was 145 g/day lower in the LoCHO vs. LoFAT group. The LoFAT group averaged lower protein intake (by 36 g/day) and lower fat intake (by 53 g/day) with an average minimum fat intake of 24% of daily energy (95% CI: 21, 27). At the time of the strictest carbohydrate restriction for the LoCHO group, the total caloric intake was not significantly different between groups (1504 vs. 1449 kcal/day for LoCHO and LoFAT, respectively)."
Eventually the data showed that in low carb diets the minimum CHO intake was 29,5 g/d which is easily doable in an everyday life. 
In conclusion this study is in keeping with strong observational nutritional data: Switzerland and France which have the most important consumption of sat fat in Europe (around 15% of TEI) have the lowest rate of CVD. And their sat fats come primarily from animal fat with a high % of cheeses.

http://www.prnewswire.com/news-releases/a-low-carb-diet-outperforms-a-low-fat-diet-when-it-comes-to-health-outcomes-300162761.html?utm_content=bufferaf3e0&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

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